File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium

TitleCyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium
Authors
Issue Date2004
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/
Citation
Journal Of Biological Chemistry, 2004, v. 279 n. 34, p. 35858-35866 How to Cite?
AbstractCell cycle withdrawal limits proliferation of adult mammalian cardiomyocytes. Therefore, the concept of stimulating myocyte mitotic divisions has dramatic implications for cardiomyocyte regeneration and hence, cardiovascular disease. Previous reports describing manipulation of cell cycle proteins have not shown induction of cardiomyocyte mitosis after birth. We now report that cyclin A2, normally silenced in the postnatal heart, induces cardiac enlargement because of cardiomyocyte hyperplasia when constitutively expressed from embryonic day 8 into adulthood. Cardiomyocyte hyperplasia during adulthood was coupled with an increase in cardiomyoctye mitosis, noted in transgenic hearts at all time points examined, particularly during postnatal development. Several stages of mitosis were observed within cardiomyocytes and correlated with the nuclear localization of cyclin A2. Magnetic resonance analysis confirmed cardiac enlargement. These results reveal a previously unrecognized critical role for cyclin A2 in mediating cardiomyocyte mitosis, a role that may significantly impact upon clinical treatment of damaged myocardium.
Persistent Identifierhttp://hdl.handle.net/10722/85420
ISSN
2015 Impact Factor: 4.258
2015 SCImago Journal Rankings: 3.151
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChaudhry, HWen_HK
dc.contributor.authorDashoush, NHen_HK
dc.contributor.authorTang, Hen_HK
dc.contributor.authorZhang, Len_HK
dc.contributor.authorWan, Xen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorWolgemuth, DJen_HK
dc.date.accessioned2010-09-06T09:04:32Z-
dc.date.available2010-09-06T09:04:32Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Biological Chemistry, 2004, v. 279 n. 34, p. 35858-35866en_HK
dc.identifier.issn0021-9258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/85420-
dc.description.abstractCell cycle withdrawal limits proliferation of adult mammalian cardiomyocytes. Therefore, the concept of stimulating myocyte mitotic divisions has dramatic implications for cardiomyocyte regeneration and hence, cardiovascular disease. Previous reports describing manipulation of cell cycle proteins have not shown induction of cardiomyocyte mitosis after birth. We now report that cyclin A2, normally silenced in the postnatal heart, induces cardiac enlargement because of cardiomyocyte hyperplasia when constitutively expressed from embryonic day 8 into adulthood. Cardiomyocyte hyperplasia during adulthood was coupled with an increase in cardiomyoctye mitosis, noted in transgenic hearts at all time points examined, particularly during postnatal development. Several stages of mitosis were observed within cardiomyocytes and correlated with the nuclear localization of cyclin A2. Magnetic resonance analysis confirmed cardiac enlargement. These results reveal a previously unrecognized critical role for cyclin A2 in mediating cardiomyocyte mitosis, a role that may significantly impact upon clinical treatment of damaged myocardium.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/en_HK
dc.relation.ispartofJournal of Biological Chemistryen_HK
dc.rightsJournal of Biological Chemistry . Copyright © American Society for Biochemistry and Molecular Biology, Inc.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCyclin A - physiologyen_HK
dc.subject.meshGene Expression Regulationen_HK
dc.subject.meshHeart Diseases - etiology - metabolism - pathologyen_HK
dc.subject.meshHyperplasiaen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Transgenicen_HK
dc.subject.meshMitosis - physiologyen_HK
dc.subject.meshMyocardium - metabolism - pathologyen_HK
dc.subject.meshMyocytes, Cardiac - pathology - physiologyen_HK
dc.titleCyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardiumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9258&volume=279&spage=35858&epage=35866&date=2004&atitle=Cyclin+A2+mediates+cardiomyocyte+mitosis+in+the+postmitotic+myocardiumen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1074/jbc.M404975200en_HK
dc.identifier.pmid15159393-
dc.identifier.scopuseid_2-s2.0-4143057167en_HK
dc.identifier.hkuros109186en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4143057167&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume279en_HK
dc.identifier.issue34en_HK
dc.identifier.spage35858en_HK
dc.identifier.epage35866en_HK
dc.identifier.isiWOS:000223303400087-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChaudhry, HW=14065840300en_HK
dc.identifier.scopusauthoridDashoush, NH=6504551155en_HK
dc.identifier.scopusauthoridTang, H=36827331000en_HK
dc.identifier.scopusauthoridZhang, L=35239292600en_HK
dc.identifier.scopusauthoridWan, X=7202533149en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridWolgemuth, DJ=7102345248en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats