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Article: Induction of apoptosis by dietary polyunsaturated fatty acids in human leukemic cells is not associated with DNA fragmentation.

TitleInduction of apoptosis by dietary polyunsaturated fatty acids in human leukemic cells is not associated with DNA fragmentation.
Authors
Issue Date2000
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/
Citation
International Journal Of Oncology, 2000, v. 17 n. 4, p. 789-796 How to Cite?
AbstractApoptosis is important in anticancer strategy. In this study, bivariate annexin V/PI flow cytometry showed that dietary polyunsaturated fatty acids, arachidonic acid (AA) and eicosapentaenoic acid (EPA), induced apoptosis in human leukemic HL-60 but not K-562 cells. Results from DNA-PI flow cytometry and TUNEL flow cytometry illustrated that neither AA nor EPA induced DNA fragmentation in the leukemic cells. These findings suggested that the AA- and EPA-induced apoptosis might not associate with endonucleases activation, and DNA fragmentation could not be used as a sole criterion to identify apoptotic cells.
Persistent Identifierhttp://hdl.handle.net/10722/84954
ISSN
2015 Impact Factor: 3.018
2015 SCImago Journal Rankings: 1.270
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChiu, LCen_HK
dc.contributor.authorWan, JMen_HK
dc.contributor.authorOoi, VEen_HK
dc.date.accessioned2010-09-06T08:59:03Z-
dc.date.available2010-09-06T08:59:03Z-
dc.date.issued2000en_HK
dc.identifier.citationInternational Journal Of Oncology, 2000, v. 17 n. 4, p. 789-796en_HK
dc.identifier.issn1019-6439en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84954-
dc.description.abstractApoptosis is important in anticancer strategy. In this study, bivariate annexin V/PI flow cytometry showed that dietary polyunsaturated fatty acids, arachidonic acid (AA) and eicosapentaenoic acid (EPA), induced apoptosis in human leukemic HL-60 but not K-562 cells. Results from DNA-PI flow cytometry and TUNEL flow cytometry illustrated that neither AA nor EPA induced DNA fragmentation in the leukemic cells. These findings suggested that the AA- and EPA-induced apoptosis might not associate with endonucleases activation, and DNA fragmentation could not be used as a sole criterion to identify apoptotic cells.en_HK
dc.languageengen_HK
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/en_HK
dc.relation.ispartofInternational journal of oncologyen_HK
dc.titleInduction of apoptosis by dietary polyunsaturated fatty acids in human leukemic cells is not associated with DNA fragmentation.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1019-6439&volume=17&spage=789&epage=796&date=2000&atitle=Induction+of+apoptosis+by+dietary+polyunsaturated+fatty+acids+in+human+leukemic+cells+is+not+associated+with+DNA+fragmentationen_HK
dc.identifier.emailWan, JM: jmfwan@hku.hken_HK
dc.identifier.authorityWan, JM=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10995893-
dc.identifier.scopuseid_2-s2.0-0034294844en_HK
dc.identifier.hkuros61095en_HK
dc.identifier.volume17en_HK
dc.identifier.issue4en_HK
dc.identifier.spage789en_HK
dc.identifier.epage796en_HK
dc.identifier.isiWOS:000089460000022-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridChiu, LC=7103129041en_HK
dc.identifier.scopusauthoridWan, JM=8930305000en_HK
dc.identifier.scopusauthoridOoi, VE=7003848784en_HK

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