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Conference Paper: The effects of perinatal protein malnutrition on spatial learning and memory behaviour and brain-derived neurotrophic factor concentration in the brain tissue in young rats

TitleThe effects of perinatal protein malnutrition on spatial learning and memory behaviour and brain-derived neurotrophic factor concentration in the brain tissue in young rats
Authors
KeywordsBDNF
Morris Water Maze
Protein malnutrition
Rat
Spatial learning
Issue Date2007
PublisherH E C Press. The Journal's web site is located at http://www.healthyeatingclub.com/APJCN/
Citation
Asia Pacific Journal Of Clinical Nutrition, 2007, v. 16 SUPPL.1, p. 467-472 How to Cite?
AbstractThis study aimed to investigate the effects of perinatal protein malnutrition on brain derived-neurotrophic factor (BDNF) concentration in brain tissue and spatial learning and memory performance in young rats. Nine pregnant Wistar rats were assigned into three groups. Rats in one group were fed with a control diet containing 20% protein. Rats in remaining two groups were fed with a diet containing 6% protein from gestation day eight and day 15 respectively till four weeks after birth. At four weeks of age, the rat pups were evaluated for spatial learning ability using Morris Water Maze (MWM) task. At the end of the behaviour tests, rat pups were sacrificed and the brain tissue samples were collected for measurement of total protein and BDNF concentrations. It was found that rat pups fed the low protein diet had lower body weight and slightly lighter brain compared to the control pups. Total protein levels in hippocampus and cerebral cortex were significantly lower in malnourished pups than the controls. The concentration of BDNF in the hippocampus was also significantly lower in rat pups suffered protein malnutrition from early pregnancy than in the controls. MWM tests showed that perinatal protein deprivation, particularly from early pregnancy, significantly impaired learning and memory ability. The results of the present study indicate that perinatal protein malnutrition had adverse influence on spatial navigation and brain BDNF levels in rats. The decreased hippocampal BDNF concentration might partially contribute to the poor learning memory performance in the protein deprived rats.
Persistent Identifierhttp://hdl.handle.net/10722/84946
ISSN
2015 Impact Factor: 1.35
2015 SCImago Journal Rankings: 0.672
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Len_HK
dc.contributor.authorXu, RJen_HK
dc.date.accessioned2010-09-06T08:58:57Z-
dc.date.available2010-09-06T08:58:57Z-
dc.date.issued2007en_HK
dc.identifier.citationAsia Pacific Journal Of Clinical Nutrition, 2007, v. 16 SUPPL.1, p. 467-472en_HK
dc.identifier.issn0964-7058en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84946-
dc.description.abstractThis study aimed to investigate the effects of perinatal protein malnutrition on brain derived-neurotrophic factor (BDNF) concentration in brain tissue and spatial learning and memory performance in young rats. Nine pregnant Wistar rats were assigned into three groups. Rats in one group were fed with a control diet containing 20% protein. Rats in remaining two groups were fed with a diet containing 6% protein from gestation day eight and day 15 respectively till four weeks after birth. At four weeks of age, the rat pups were evaluated for spatial learning ability using Morris Water Maze (MWM) task. At the end of the behaviour tests, rat pups were sacrificed and the brain tissue samples were collected for measurement of total protein and BDNF concentrations. It was found that rat pups fed the low protein diet had lower body weight and slightly lighter brain compared to the control pups. Total protein levels in hippocampus and cerebral cortex were significantly lower in malnourished pups than the controls. The concentration of BDNF in the hippocampus was also significantly lower in rat pups suffered protein malnutrition from early pregnancy than in the controls. MWM tests showed that perinatal protein deprivation, particularly from early pregnancy, significantly impaired learning and memory ability. The results of the present study indicate that perinatal protein malnutrition had adverse influence on spatial navigation and brain BDNF levels in rats. The decreased hippocampal BDNF concentration might partially contribute to the poor learning memory performance in the protein deprived rats.en_HK
dc.languageengen_HK
dc.publisherH E C Press. The Journal's web site is located at http://www.healthyeatingclub.com/APJCN/en_HK
dc.relation.ispartofAsia Pacific Journal of Clinical Nutritionen_HK
dc.subjectBDNFen_HK
dc.subjectMorris Water Mazeen_HK
dc.subjectProtein malnutritionen_HK
dc.subjectRaten_HK
dc.subjectSpatial learningen_HK
dc.titleThe effects of perinatal protein malnutrition on spatial learning and memory behaviour and brain-derived neurotrophic factor concentration in the brain tissue in young ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1361-3286&volume=16 &issue=Suppl&spage=467&epage=472&date=2007&atitle=The+effects+of+perinatal+protein+malnutrition+on+spatial+learning+and+memory+behaviour+and+brain-derived+neurotrophic+factor+concentration+in+the+brain+tissue+in+young+ratsen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17392152-
dc.identifier.scopuseid_2-s2.0-34047165952en_HK
dc.identifier.hkuros134688en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34047165952&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issueSUPPL.1en_HK
dc.identifier.spage467en_HK
dc.identifier.epage472en_HK
dc.identifier.isiWOS:000245926500086-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridWang, L=35486456100en_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK

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