File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Endogenous release of secretin from the hypothalamus

TitleEndogenous release of secretin from the hypothalamus
Authors
KeywordsCalcium channel
Depolarization-evoked release
Hypothalamus
Secretin
Issue Date2006
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1
Citation
Annals Of The New York Academy Of Sciences, 2006, v. 1070, p. 196-200 How to Cite?
AbstractPrevious studies demonstrated that secretin could be released from the cerebellum, where it exerts a facilitatory action on the GABAergic inputs into the Purkinje neurons. In the present article, we provide evidence of the endogenous release of secretin in the hypothalamus and the mechanisms underlying this release. Incubation of the hypothalamic expiants with KCl induces the release of secretin to 4.35 ± 0.45-fold of the basal level. This K +-induced release was tetrodotoxin and cadmium sensitive, suggesting the involvement of voltage-gated sodium and calcium channels. The use of specific blockers further revealed the involvement of L-, N-, and P-type high voltage-activated (HVA) calcium channels. Results present in the current article provide further and more solid evidence of the role of secretin as a neuropeptide in the mammalian central nervous system. © 2006 New York Academy of Sciences.
Persistent Identifierhttp://hdl.handle.net/10722/84944
ISSN
2015 Impact Factor: 4.518
2015 SCImago Journal Rankings: 2.389
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, JYSen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-06T08:58:56Z-
dc.date.available2010-09-06T08:58:56Z-
dc.date.issued2006en_HK
dc.identifier.citationAnnals Of The New York Academy Of Sciences, 2006, v. 1070, p. 196-200en_HK
dc.identifier.issn0077-8923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84944-
dc.description.abstractPrevious studies demonstrated that secretin could be released from the cerebellum, where it exerts a facilitatory action on the GABAergic inputs into the Purkinje neurons. In the present article, we provide evidence of the endogenous release of secretin in the hypothalamus and the mechanisms underlying this release. Incubation of the hypothalamic expiants with KCl induces the release of secretin to 4.35 ± 0.45-fold of the basal level. This K +-induced release was tetrodotoxin and cadmium sensitive, suggesting the involvement of voltage-gated sodium and calcium channels. The use of specific blockers further revealed the involvement of L-, N-, and P-type high voltage-activated (HVA) calcium channels. Results present in the current article provide further and more solid evidence of the role of secretin as a neuropeptide in the mammalian central nervous system. © 2006 New York Academy of Sciences.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1en_HK
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_HK
dc.subjectCalcium channelen_HK
dc.subjectDepolarization-evoked releaseen_HK
dc.subjectHypothalamusen_HK
dc.subjectSecretinen_HK
dc.titleEndogenous release of secretin from the hypothalamusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0077-8923&volume=1070&spage=p.196&epage=200&date=2006&atitle=Endogenous+release+of+secretin+from+the+hypothalamusen_HK
dc.identifier.emailChu, JYS: hitan@graduate.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityChu, JYS=rp00684en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1196/annals.1317.012en_HK
dc.identifier.pmid16888165-
dc.identifier.scopuseid_2-s2.0-33746457317en_HK
dc.identifier.hkuros122744en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746457317&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1070en_HK
dc.identifier.spage196en_HK
dc.identifier.epage200en_HK
dc.identifier.isiWOS:000240364200021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChu, JYS=34975209300en_HK
dc.identifier.scopusauthoridYung, WH=7103137893en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats