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Article: Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells.

TitleEicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells.
Authors
Issue Date2001
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/
Citation
International Journal Of Oncology, 2001, v. 19 n. 4, p. 845-849 How to Cite?
AbstractEicosapentaenoic acid (EPA) is a polyunsaturated fatty acid (20:5omega3) found primarily in aquatic organisms. We have shown previously that EPA inhibits the growth but is not toxic to human leukemic K-562 cells. In this study, the anti-proliferative effect of EPA on the leukemic cells was further determined and its impacts on cell cycle progression and cyclin expression were investigated. EPA inhibited proliferation of K-562 cells, which was associated with accumulation of G0/G1 cells and down-regulation of cyclin E expression. Cyclin B1-expressing cells were also reduced showing that down-regulation of cyclin expression might be important in the anti-proliferation of EPA.
Persistent Identifierhttp://hdl.handle.net/10722/84942
ISSN
2015 Impact Factor: 3.018
2015 SCImago Journal Rankings: 1.270
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChiu, LCen_HK
dc.contributor.authorOoi, VEen_HK
dc.contributor.authorWan, JMen_HK
dc.date.accessioned2010-09-06T08:58:55Z-
dc.date.available2010-09-06T08:58:55Z-
dc.date.issued2001en_HK
dc.identifier.citationInternational Journal Of Oncology, 2001, v. 19 n. 4, p. 845-849en_HK
dc.identifier.issn1019-6439en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84942-
dc.description.abstractEicosapentaenoic acid (EPA) is a polyunsaturated fatty acid (20:5omega3) found primarily in aquatic organisms. We have shown previously that EPA inhibits the growth but is not toxic to human leukemic K-562 cells. In this study, the anti-proliferative effect of EPA on the leukemic cells was further determined and its impacts on cell cycle progression and cyclin expression were investigated. EPA inhibited proliferation of K-562 cells, which was associated with accumulation of G0/G1 cells and down-regulation of cyclin E expression. Cyclin B1-expressing cells were also reduced showing that down-regulation of cyclin expression might be important in the anti-proliferation of EPA.en_HK
dc.languageengen_HK
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/en_HK
dc.relation.ispartofInternational journal of oncologyen_HK
dc.titleEicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1019-6439&volume=19&spage=845&epage=849&date=2001&atitle=Eicosapentaenoic+acid+modulates+cyclin+expression+and+arrests+cell+cycle+progression+in+human+leukemic+K-562+cellsen_HK
dc.identifier.emailWan, JM: jmfwan@hku.hken_HK
dc.identifier.authorityWan, JM=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11562765-
dc.identifier.scopuseid_2-s2.0-0035487196en_HK
dc.identifier.hkuros66921en_HK
dc.identifier.volume19en_HK
dc.identifier.issue4en_HK
dc.identifier.spage845en_HK
dc.identifier.epage849en_HK
dc.identifier.isiWOS:000171135600028-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridChiu, LC=7103129041en_HK
dc.identifier.scopusauthoridOoi, VE=7003848784en_HK
dc.identifier.scopusauthoridWan, JM=8930305000en_HK

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