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Article: Effects of colostrum feeding on intestinal development in newborn pigs

TitleEffects of colostrum feeding on intestinal development in newborn pigs
Authors
KeywordsColostrum
Enzyme
Growth factor
Intestine
Issue Date1996
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/BON
Citation
Biology Of The Neonate, 1996, v. 70 n. 6, p. 339-348 How to Cite?
AbstractTo investigate what factors lead to rapid postnatal tissue growth and functional maturation in the newborn intestine, we compared intestinal tissue mass and digestive enzyme activities between newborn unsuckled piglets and piglets bottle fed for 3 days with either 5% lactose solution, intact porcine colostrum or trypsinized porcine colostrum. Bottle feeding of colostrum or trypsinized colostrum, but not lactose solution, led to a significant increase in the weight and length of the small intestine (p < 0.01) and a significant increase in the mucosal weight of the large intestine (p < 0.05). The mucosal protein content in the small and large intestine and the mucosal DNA content in the large intestine increased significantly following 3 days of bottle feeding of porcine colostrum or trypsinized colostrum. The total mucosal DNA contents in the small intestine of piglets fed colostrum or trypsinized colostrum were, respectively, 39 and 64% greater than that in the newborn unsuckled piglets. Intestinal digestive enzymes showed a differential response to the dietary treatment. Bottle feeding of intact porcine colostrum, but not trypsinized porcine colostrum led to a significant increase in lactase- and alkaline phosphatase-specific activities in the small intestine, while bottle feeding of lactose solution led to a significant decrease in the specific activity of lactase. In contrast, the specific activity of maltase in the small intestine increased significantly with age irrespective of dietary treatment. These results indicate that genetic and dietary factors are involved in regulating postnatal intestinal development, and porcine colostrum contains a trypsin-labile component which can increase lactase and alkaline phosphatase activities in the newborn intestine.
Persistent Identifierhttp://hdl.handle.net/10722/84930
ISSN
2008 Impact Factor: 1.741
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Ten_HK
dc.contributor.authorXu, RJen_HK
dc.date.accessioned2010-09-06T08:58:46Z-
dc.date.available2010-09-06T08:58:46Z-
dc.date.issued1996en_HK
dc.identifier.citationBiology Of The Neonate, 1996, v. 70 n. 6, p. 339-348en_HK
dc.identifier.issn0006-3126en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84930-
dc.description.abstractTo investigate what factors lead to rapid postnatal tissue growth and functional maturation in the newborn intestine, we compared intestinal tissue mass and digestive enzyme activities between newborn unsuckled piglets and piglets bottle fed for 3 days with either 5% lactose solution, intact porcine colostrum or trypsinized porcine colostrum. Bottle feeding of colostrum or trypsinized colostrum, but not lactose solution, led to a significant increase in the weight and length of the small intestine (p < 0.01) and a significant increase in the mucosal weight of the large intestine (p < 0.05). The mucosal protein content in the small and large intestine and the mucosal DNA content in the large intestine increased significantly following 3 days of bottle feeding of porcine colostrum or trypsinized colostrum. The total mucosal DNA contents in the small intestine of piglets fed colostrum or trypsinized colostrum were, respectively, 39 and 64% greater than that in the newborn unsuckled piglets. Intestinal digestive enzymes showed a differential response to the dietary treatment. Bottle feeding of intact porcine colostrum, but not trypsinized porcine colostrum led to a significant increase in lactase- and alkaline phosphatase-specific activities in the small intestine, while bottle feeding of lactose solution led to a significant decrease in the specific activity of lactase. In contrast, the specific activity of maltase in the small intestine increased significantly with age irrespective of dietary treatment. These results indicate that genetic and dietary factors are involved in regulating postnatal intestinal development, and porcine colostrum contains a trypsin-labile component which can increase lactase and alkaline phosphatase activities in the newborn intestine.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/BONen_HK
dc.relation.ispartofBiology of the Neonateen_HK
dc.rightsBiology of the Neonate. Copyright © S Karger AG.en_HK
dc.subjectColostrumen_HK
dc.subjectEnzymeen_HK
dc.subjectGrowth factoren_HK
dc.subjectIntestineen_HK
dc.titleEffects of colostrum feeding on intestinal development in newborn pigsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3126&volume=70&spage=339&epage=348&date=1996&atitle=Effects+of+colostrum+feeding+on+intestinal+development+in+newborn+pigsen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9001695-
dc.identifier.scopuseid_2-s2.0-0030472281en_HK
dc.identifier.hkuros21311en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030472281&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue6en_HK
dc.identifier.spage339en_HK
dc.identifier.epage348en_HK
dc.identifier.isiWOS:A1996WB44800004-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridWang, T=16237768300en_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK

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