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Article: Oral ingestion of colostrum alters intestinal transforming growth factor-beta receptor intensity in newborn pigs

TitleOral ingestion of colostrum alters intestinal transforming growth factor-beta receptor intensity in newborn pigs
Authors
KeywordsBovine colostrum
Intestine
Newborn pig
Porcine colostrum
TGF-β receptors
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/706547/description#description
Citation
Livestock Science, 2006, v. 105 n. 1-3, p. 214-222 How to Cite?
AbstractMammary gland secretion contains numerous bioactive compounds including transforming growth factor-beta (TGF-β). The concentrations of such bioactive compounds are usually much higher in colostrum compared with those in mature milk. To investigate possible effects of colostrum-borne TGF-β on the suckling animal, newborn piglets were naturally suckled or bottle-fed with porcine colostrum, bovine colostrum, porcine milk, infant formula or water for 24 h and intestinal TGF-β receptor intensity was assessed using an immunohistochemical staining technique in combination with computerized image analysis. The intestinal structure was also analyzed by morphometric analysis technique. It was observed that newborn pigs naturally suckled or bottle-fed with porcine or bovine colostrum had significantly greater intestinal villous height and crypt depth when compared with those fed with porcine milk, infant formula or water (p < 0.05). The immunostaining intensity for TGF-β receptors in the intestinal epithelium, particularly on the apical membrane of the villous epithelium, was significantly lower in naturally suckled or colostrum fed piglets compared with that in piglets fed with milk, infant formula or water (p < 0.05). Such decline in receptor intensity is likely the result of receptor internalization and degradation following exposure to colostrum-borne TGF-β. These findings suggest that colostrum-borne TGF-β can modulate intestinal TGF-β signalling pathways and may play a role in postnatal adaptation of the gut in newborn pigs. © 2006 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84897
ISSN
2015 Impact Factor: 1.293
2015 SCImago Journal Rankings: 0.837
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMei, Jen_HK
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorWang, Ten_HK
dc.contributor.authorSangild, PTen_HK
dc.contributor.authorXu, RJen_HK
dc.date.accessioned2010-09-06T08:58:23Z-
dc.date.available2010-09-06T08:58:23Z-
dc.date.issued2006en_HK
dc.identifier.citationLivestock Science, 2006, v. 105 n. 1-3, p. 214-222en_HK
dc.identifier.issn1871-1413en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84897-
dc.description.abstractMammary gland secretion contains numerous bioactive compounds including transforming growth factor-beta (TGF-β). The concentrations of such bioactive compounds are usually much higher in colostrum compared with those in mature milk. To investigate possible effects of colostrum-borne TGF-β on the suckling animal, newborn piglets were naturally suckled or bottle-fed with porcine colostrum, bovine colostrum, porcine milk, infant formula or water for 24 h and intestinal TGF-β receptor intensity was assessed using an immunohistochemical staining technique in combination with computerized image analysis. The intestinal structure was also analyzed by morphometric analysis technique. It was observed that newborn pigs naturally suckled or bottle-fed with porcine or bovine colostrum had significantly greater intestinal villous height and crypt depth when compared with those fed with porcine milk, infant formula or water (p < 0.05). The immunostaining intensity for TGF-β receptors in the intestinal epithelium, particularly on the apical membrane of the villous epithelium, was significantly lower in naturally suckled or colostrum fed piglets compared with that in piglets fed with milk, infant formula or water (p < 0.05). Such decline in receptor intensity is likely the result of receptor internalization and degradation following exposure to colostrum-borne TGF-β. These findings suggest that colostrum-borne TGF-β can modulate intestinal TGF-β signalling pathways and may play a role in postnatal adaptation of the gut in newborn pigs. © 2006 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/706547/description#descriptionen_HK
dc.relation.ispartofLivestock Scienceen_HK
dc.rightsLivestock Science. Copyright © Elsevier BV.en_HK
dc.subjectBovine colostrumen_HK
dc.subjectIntestineen_HK
dc.subjectNewborn pigen_HK
dc.subjectPorcine colostrumen_HK
dc.subjectTGF-β receptorsen_HK
dc.titleOral ingestion of colostrum alters intestinal transforming growth factor-beta receptor intensity in newborn pigsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1871-1413&volume=105&spage=214&epage=222&date=2006&atitle=Oral+ingestion+of+colostrum+alters+intestinal+transforming+growth+factor-beta+receptor+intensity+in+newborn+pigs.en_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.livsci.2006.06.017en_HK
dc.identifier.scopuseid_2-s2.0-33750436956en_HK
dc.identifier.hkuros134691en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750436956&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume105en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage214en_HK
dc.identifier.epage222en_HK
dc.identifier.isiWOS:000242564700026-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridMei, J=36857285200en_HK
dc.identifier.scopusauthoridZhang, Y=7601321843en_HK
dc.identifier.scopusauthoridWang, T=7405564454en_HK
dc.identifier.scopusauthoridSangild, PT=7004115316en_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK

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