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Article: Identification of repressor element 1 in secretin/PACAP/VIP genes

TitleIdentification of repressor element 1 in secretin/PACAP/VIP genes
Authors
KeywordsRepressor element 1
Secretin/PACAP/VIP peptide family
Transcriptional regulation
Issue Date2006
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1
Citation
Annals Of The New York Academy Of Sciences, 2006, v. 1070, p. 388-392 How to Cite?
AbstractRepressor element 1 (RE-1) is a negative, cis-acting regulatory element that interacts with the transcription factor RE-1-silencing transcription factor (REST). REST represses gene expression by two repressor domains that recruit other factors including mSin3 and CoREST. RE-1 has been identified in an increasing number of neuronal-specific genes, and recently, functional REST sites have also been discovered in VIP and PACAP genes. In the present article, we demonstrated for the first time that RE-1 sites are present in the 5′ flanking regions of several secretin/PACAP/VIP genes by in silico analysis. This observation suggests that RE-1/REST is a common negative regulatory pathway of this peptide family. © 2006 New York Academy of Sciences.
Persistent Identifierhttp://hdl.handle.net/10722/84896
ISSN
2015 Impact Factor: 4.518
2015 SCImago Journal Rankings: 2.389
ISI Accession Number ID
References
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DC FieldValueLanguage
dc.contributor.authorLee, LTOen_HK
dc.contributor.authorLee, VHYen_HK
dc.contributor.authorYuan, PYen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-06T08:58:23Z-
dc.date.available2010-09-06T08:58:23Z-
dc.date.issued2006en_HK
dc.identifier.citationAnnals Of The New York Academy Of Sciences, 2006, v. 1070, p. 388-392en_HK
dc.identifier.issn0077-8923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84896-
dc.description.abstractRepressor element 1 (RE-1) is a negative, cis-acting regulatory element that interacts with the transcription factor RE-1-silencing transcription factor (REST). REST represses gene expression by two repressor domains that recruit other factors including mSin3 and CoREST. RE-1 has been identified in an increasing number of neuronal-specific genes, and recently, functional REST sites have also been discovered in VIP and PACAP genes. In the present article, we demonstrated for the first time that RE-1 sites are present in the 5′ flanking regions of several secretin/PACAP/VIP genes by in silico analysis. This observation suggests that RE-1/REST is a common negative regulatory pathway of this peptide family. © 2006 New York Academy of Sciences.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1en_HK
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_HK
dc.subjectRepressor element 1en_HK
dc.subjectSecretin/PACAP/VIP peptide familyen_HK
dc.subjectTranscriptional regulationen_HK
dc.titleIdentification of repressor element 1 in secretin/PACAP/VIP genesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0077-8923&volume=1070&spage=388&epage=392&date=2006&atitle=Identification+of+repressor+element+1+in+secretin/PACAP/VIP+genesen_HK
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityLee, LTO=rp00727en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1196/annals.1317.050en_HK
dc.identifier.pmid16888197-
dc.identifier.scopuseid_2-s2.0-33746427487en_HK
dc.identifier.hkuros122701en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746427487&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1070en_HK
dc.identifier.spage388en_HK
dc.identifier.epage392en_HK
dc.identifier.isiWOS:000240364200054-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectSecretin as a neuropeptide-
dc.identifier.scopusauthoridLee, LTO=8367269000en_HK
dc.identifier.scopusauthoridLee, VHY=14050662700en_HK
dc.identifier.scopusauthoridYuan, PY=14051170300en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

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