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Article: Cytokines and junction restructuring during spermatogenesis - A lesson to learn from the testis

TitleCytokines and junction restructuring during spermatogenesis - A lesson to learn from the testis
Authors
KeywordsAdaptors
Adherens junction
Blood-testis barrier
Cytokines
Ectoplasmic specialization
ERK
JNK
Junction restructuring
p38 MAPK
Spermatogenesis
Testis
TGF-β3
Tight junction
TNFα
Issue Date2005
PublisherElsevier Ltd. The Journal's web site is located at BIOLOGY - BIOCHEMISTRY
Citation
Cytokine And Growth Factor Reviews, 2005, v. 16 n. 4-5, p. 469-493 How to Cite?
AbstractIn the mammalian testis, preleptotene and leptotene spermatocytes residing in the basal compartment of the seminiferous epithelium must traverse the blood-testis barrier (BTB) at late stage VIII through early stage IX of the epithelial cycle during spermatogenesis, entering the adluminal compartment for further development. However, until recently the regulatory mechanisms that regulate BTB dynamics remained largely unknown. We provide a critical review regarding the significance of cytokines in regulating the 'opening' and 'closing' of the BTB. We also discuss how cytokines may be working in concert with adaptors that selectively govern the downstream signaling pathways. This process, in turn, regulates the dynamics of either Sertoli-Sertoli tight junction (TJ), Sertoli-germ cell adherens junction (AJ), or both junction types in the epithelium, thereby permitting TJ opening without compromising AJs, and vice versa. We also discuss how adaptors alter their protein-protein association with the integral membrane proteins at the cell-cell interface via changes in their phosphorylation status, thereby altering adhesion function at AJ. These findings illustrate that the testis is a novel in vivo model to study the biology of junction restructuring. Furthermore, a molecular model is presented regarding how cytokines selectively regulate TJ/AJ restructuring in the epithelium during spermatogenesis. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84892
ISSN
2015 Impact Factor: 6.571
2015 SCImago Journal Rankings: 3.018
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXia, Wen_HK
dc.contributor.authorMruk, DDen_HK
dc.contributor.authorLee, WMen_HK
dc.contributor.authorCheng, CYen_HK
dc.date.accessioned2010-09-06T08:58:20Z-
dc.date.available2010-09-06T08:58:20Z-
dc.date.issued2005en_HK
dc.identifier.citationCytokine And Growth Factor Reviews, 2005, v. 16 n. 4-5, p. 469-493en_HK
dc.identifier.issn1359-6101en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84892-
dc.description.abstractIn the mammalian testis, preleptotene and leptotene spermatocytes residing in the basal compartment of the seminiferous epithelium must traverse the blood-testis barrier (BTB) at late stage VIII through early stage IX of the epithelial cycle during spermatogenesis, entering the adluminal compartment for further development. However, until recently the regulatory mechanisms that regulate BTB dynamics remained largely unknown. We provide a critical review regarding the significance of cytokines in regulating the 'opening' and 'closing' of the BTB. We also discuss how cytokines may be working in concert with adaptors that selectively govern the downstream signaling pathways. This process, in turn, regulates the dynamics of either Sertoli-Sertoli tight junction (TJ), Sertoli-germ cell adherens junction (AJ), or both junction types in the epithelium, thereby permitting TJ opening without compromising AJs, and vice versa. We also discuss how adaptors alter their protein-protein association with the integral membrane proteins at the cell-cell interface via changes in their phosphorylation status, thereby altering adhesion function at AJ. These findings illustrate that the testis is a novel in vivo model to study the biology of junction restructuring. Furthermore, a molecular model is presented regarding how cytokines selectively regulate TJ/AJ restructuring in the epithelium during spermatogenesis. © 2005 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at BIOLOGY - BIOCHEMISTRYen_HK
dc.relation.ispartofCytokine and Growth Factor Reviewsen_HK
dc.rightsCytokine & Growth Factor Reviews. Copyright © Elsevier Ltd.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAdaptorsen_HK
dc.subjectAdherens junctionen_HK
dc.subjectBlood-testis barrieren_HK
dc.subjectCytokinesen_HK
dc.subjectEctoplasmic specializationen_HK
dc.subjectERKen_HK
dc.subjectJNKen_HK
dc.subjectJunction restructuringen_HK
dc.subjectp38 MAPKen_HK
dc.subjectSpermatogenesisen_HK
dc.subjectTestisen_HK
dc.subjectTGF-β3en_HK
dc.subjectTight junctionen_HK
dc.subjectTNFαen_HK
dc.titleCytokines and junction restructuring during spermatogenesis - A lesson to learn from the testisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-6101&volume=16&spage=469&epage=493&date=2005&atitle=Cytokines+And+Junction+Restructuring+During+Spermatogenesis+–+A+Lesson+To+Learn+From+The+Testis.+en_HK
dc.identifier.emailLee, WM: hrszlwm@hku.hken_HK
dc.identifier.authorityLee, WM=rp00728en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.cytogfr.2005.05.007en_HK
dc.identifier.pmid16023885-
dc.identifier.scopuseid_2-s2.0-22544470331en_HK
dc.identifier.hkuros111280en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-22544470331&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue4-5en_HK
dc.identifier.spage469en_HK
dc.identifier.epage493en_HK
dc.identifier.isiWOS:000231332000007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXia, W=8672244100en_HK
dc.identifier.scopusauthoridMruk, DD=6701823934en_HK
dc.identifier.scopusauthoridLee, WM=24799156600en_HK
dc.identifier.scopusauthoridCheng, CY=7404797787en_HK
dc.identifier.citeulike11893046-

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