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Article: Secretin controls anion secretion in the rat epididymis in an autocrine/paracrine fashion

TitleSecretin controls anion secretion in the rat epididymis in an autocrine/paracrine fashion
Authors
KeywordsEpididymis
Male reproductive tract
Issue Date2004
PublisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/
Citation
Biology Of Reproduction, 2004, v. 70 n. 6, p. 1594-1599 How to Cite?
AbstractThere is growing evidence that secretin, the first hormone discovered in our history, has functions in the brain other than in the gastrointestinal tract. This article reports for the first time that secretin and its receptor mRNAs are produced in distinct cell types within the epididymis. To test if secretin affects electrolyte transport in the epididymis, we measured short-circuit current (Isc) in cultured epididymal epithelia and found secretin dose-dependently stimulated Isc. Ion substitution experiments and use of pharmacological agents inferred that the stimulated Isc is a result of concurrent electrogenic chloride and bicarbonate secretion. It is further shown that secretin and pituitary adenylate cyclase-activating polypeptide (PACAP) function via totally different mechanisms: 1) PACAP works only from the apical side of the epithelium to stimulate chloride and not bicarbonate secretion, while secretin acts on the apical and basolateral sides to stimulate chloride and bicarbonate secretion. 2) the stimulation by PACAP but not secretin requires local prostaglandin synthesis. By immunocytochemical staining, secretin is localized in the principal cells of the initial segment and caput epididymidis, whereas secretin receptor is present in the principal cells of the proximal as well as the distal part of the epididymis. This pattern of distribution appears to be consistent with the idea that secretin is secreted by the proximal epididymis and acts on the proximal and distal epididymis in an autocrine and paracrine fashion. Its function is to control secretion of electrolytes and water.
Persistent Identifierhttp://hdl.handle.net/10722/84891
ISSN
2015 Impact Factor: 3.471
2015 SCImago Journal Rankings: 1.646
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, BKCen_HK
dc.contributor.authorCheung, KHen_HK
dc.contributor.authorTsang, EMWen_HK
dc.contributor.authorLeung, MCTen_HK
dc.contributor.authorLee, SMYen_HK
dc.contributor.authorWong, PYDen_HK
dc.date.accessioned2010-09-06T08:58:19Z-
dc.date.available2010-09-06T08:58:19Z-
dc.date.issued2004en_HK
dc.identifier.citationBiology Of Reproduction, 2004, v. 70 n. 6, p. 1594-1599en_HK
dc.identifier.issn0006-3363en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84891-
dc.description.abstractThere is growing evidence that secretin, the first hormone discovered in our history, has functions in the brain other than in the gastrointestinal tract. This article reports for the first time that secretin and its receptor mRNAs are produced in distinct cell types within the epididymis. To test if secretin affects electrolyte transport in the epididymis, we measured short-circuit current (Isc) in cultured epididymal epithelia and found secretin dose-dependently stimulated Isc. Ion substitution experiments and use of pharmacological agents inferred that the stimulated Isc is a result of concurrent electrogenic chloride and bicarbonate secretion. It is further shown that secretin and pituitary adenylate cyclase-activating polypeptide (PACAP) function via totally different mechanisms: 1) PACAP works only from the apical side of the epithelium to stimulate chloride and not bicarbonate secretion, while secretin acts on the apical and basolateral sides to stimulate chloride and bicarbonate secretion. 2) the stimulation by PACAP but not secretin requires local prostaglandin synthesis. By immunocytochemical staining, secretin is localized in the principal cells of the initial segment and caput epididymidis, whereas secretin receptor is present in the principal cells of the proximal as well as the distal part of the epididymis. This pattern of distribution appears to be consistent with the idea that secretin is secreted by the proximal epididymis and acts on the proximal and distal epididymis in an autocrine and paracrine fashion. Its function is to control secretion of electrolytes and water.en_HK
dc.languageengen_HK
dc.publisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/en_HK
dc.relation.ispartofBiology of Reproductionen_HK
dc.subjectEpididymisen_HK
dc.subjectMale reproductive tracten_HK
dc.subject.meshAdenylate Cyclase - antagonists and inhibitors-
dc.subject.meshAnimals-
dc.subject.meshEpididymis - cytology - drug effects - metabolism-
dc.subject.meshReceptors, Gastrointestinal Hormone - genetics - metabolism-
dc.subject.meshSecretin - genetics - metabolism-
dc.titleSecretin controls anion secretion in the rat epididymis in an autocrine/paracrine fashionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3363&volume=70&issue=6&spage=1594&epage=1599&date=2004&atitle=Secretin+controls+anion+secretion+in+the+rat+epididymis+in+an+autocrine/paracrine+fashionen_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.emailCheung, KH: ckingho@hku.hken_HK
dc.identifier.emailLee, SMY: suki@hku.hken_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.identifier.authorityCheung, KH=rp01463en_HK
dc.identifier.authorityLee, SMY=rp01536en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1095/biolreprod.103.024257en_HK
dc.identifier.pmid14749298-
dc.identifier.scopuseid_2-s2.0-2642561171en_HK
dc.identifier.hkuros91134en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2642561171&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1594en_HK
dc.identifier.epage1599en_HK
dc.identifier.isiWOS:000221606200007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK
dc.identifier.scopusauthoridCheung, KH=14007487800en_HK
dc.identifier.scopusauthoridTsang, EMW=7004402526en_HK
dc.identifier.scopusauthoridLeung, MCT=8636020500en_HK
dc.identifier.scopusauthoridLee, SMY=35435155600en_HK
dc.identifier.scopusauthoridWong, PYD=7403980262en_HK

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