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Article: Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).
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TitleMolecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).
 
AuthorsChow, KY1
Hon, CC1
Hui, RK1
Wong, RT1
Yip, CW1
Zeng, F1
Leung, FC1
 
Issue Date2003
 
PublisherKexue Chubanshe.
 
CitationGenomics Proteomics Bioinformatics, 2003, v. 1 n. 4, p. 247-262 [How to Cite?]
 
AbstractThe sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information.
 
ISSN1672-0229
2012 SCImago Journal Rankings: 0.432
 
DC FieldValue
dc.contributor.authorChow, KY
 
dc.contributor.authorHon, CC
 
dc.contributor.authorHui, RK
 
dc.contributor.authorWong, RT
 
dc.contributor.authorYip, CW
 
dc.contributor.authorZeng, F
 
dc.contributor.authorLeung, FC
 
dc.date.accessioned2010-09-06T08:58:16Z
 
dc.date.available2010-09-06T08:58:16Z
 
dc.date.issued2003
 
dc.description.abstractThe sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationGenomics Proteomics Bioinformatics, 2003, v. 1 n. 4, p. 247-262 [How to Cite?]
 
dc.identifier.epage262
 
dc.identifier.hkuros85755
 
dc.identifier.issn1672-0229
2012 SCImago Journal Rankings: 0.432
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmid15629054
 
dc.identifier.scopuseid_2-s2.0-13844281686
 
dc.identifier.spage247
 
dc.identifier.urihttp://hdl.handle.net/10722/84886
 
dc.identifier.volume1
 
dc.languageeng
 
dc.publisherKexue Chubanshe.
 
dc.publisher.placeChina
 
dc.relation.ispartofGenomics Proteomics Bioinformatics
 
dc.titleMolecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).
 
dc.typeArticle
 
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<contributor.author>Hon, CC</contributor.author>
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<contributor.author>Wong, RT</contributor.author>
<contributor.author>Yip, CW</contributor.author>
<contributor.author>Zeng, F</contributor.author>
<contributor.author>Leung, FC</contributor.author>
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Author Affiliations
  1. The University of Hong Kong