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Article: Gonadotropin and its role in the β-catenin/T-cell factor signaling pathway

TitleGonadotropin and its role in the β-catenin/T-cell factor signaling pathway
Authors
Keywordsβ-catenin
Adhesion
Gonadotropin
Ovarian cancer
Signaling
Issue Date2007
PublisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/eem
Citation
Expert Review Of Endocrinology And Metabolism, 2007, v. 2 n. 3, p. 375-385 How to Cite?
AbstractGonadotropins, follicle-stimulating hormone and luteinizing hormone are key regulators in ovarian function, acting in an endocrine manner to regulate gametogenesis and steroidogenesis. In addition to normal tissue, gonadotropin receptors have also been demonstrated in ovarian carcinoma cell lines and primary tumors, suggesting that the gonadotropins may play a role in the pathophysiology of ovarian cancer. Thus, understanding mechanisms involved in signaling transduction by the gonadotropin receptors are of considerable interest and potential significance. In the ovary, gonadotropins initiate their cellular responses by binding to their G-protein-coupled receptors and activation of specific downstream intracellular effectors and signal pathways, including those of protein kinases A and C and mitogen-activated protein kinase. Recently, gonadotropins were shown to stimulate nuclear accumulation of β-catenin, which controls lymphoid-enhancing factor/ T-cell factor family-sensitive gene expression. β-catenin has a pivotal function in the control of cell fate. The ability of gonadotropins to regulate β-catenin provides a new dimension of knowledge linking pituitary hormones to the β-catenin signaling in normal ovarian physiology and demonstrating how its dysregulation can contribute to the development of ovarian cancer. © 2007 Future Drugs Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/84842
ISSN
2015 SCImago Journal Rankings: 0.319
References

 

DC FieldValueLanguage
dc.contributor.authorPon, YLen_HK
dc.contributor.authorWong, ASTen_HK
dc.date.accessioned2010-09-06T08:57:45Z-
dc.date.available2010-09-06T08:57:45Z-
dc.date.issued2007en_HK
dc.identifier.citationExpert Review Of Endocrinology And Metabolism, 2007, v. 2 n. 3, p. 375-385en_HK
dc.identifier.issn1744-6651en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84842-
dc.description.abstractGonadotropins, follicle-stimulating hormone and luteinizing hormone are key regulators in ovarian function, acting in an endocrine manner to regulate gametogenesis and steroidogenesis. In addition to normal tissue, gonadotropin receptors have also been demonstrated in ovarian carcinoma cell lines and primary tumors, suggesting that the gonadotropins may play a role in the pathophysiology of ovarian cancer. Thus, understanding mechanisms involved in signaling transduction by the gonadotropin receptors are of considerable interest and potential significance. In the ovary, gonadotropins initiate their cellular responses by binding to their G-protein-coupled receptors and activation of specific downstream intracellular effectors and signal pathways, including those of protein kinases A and C and mitogen-activated protein kinase. Recently, gonadotropins were shown to stimulate nuclear accumulation of β-catenin, which controls lymphoid-enhancing factor/ T-cell factor family-sensitive gene expression. β-catenin has a pivotal function in the control of cell fate. The ability of gonadotropins to regulate β-catenin provides a new dimension of knowledge linking pituitary hormones to the β-catenin signaling in normal ovarian physiology and demonstrating how its dysregulation can contribute to the development of ovarian cancer. © 2007 Future Drugs Ltd.en_HK
dc.languageengen_HK
dc.publisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/eemen_HK
dc.relation.ispartofExpert Review of Endocrinology and Metabolismen_HK
dc.subjectβ-cateninen_HK
dc.subjectAdhesionen_HK
dc.subjectGonadotropinen_HK
dc.subjectOvarian canceren_HK
dc.subjectSignalingen_HK
dc.titleGonadotropin and its role in the β-catenin/T-cell factor signaling pathwayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1744-6651&volume=2&spage=375&epage=385&date=2007&atitle=Gonadotropin+and+its+role+in+the+β-catenin/T-cell+factor+signaling+pathwayen_HK
dc.identifier.emailWong, AST: awong1@hkucc.hku.hken_HK
dc.identifier.authorityWong, AST=rp00805en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1586/17446651.2.3.375en_HK
dc.identifier.scopuseid_2-s2.0-34347332256en_HK
dc.identifier.hkuros130198en_HK
dc.identifier.hkuros152152-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34347332256&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue3en_HK
dc.identifier.spage375en_HK
dc.identifier.epage385en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPon, YL=22235406500en_HK
dc.identifier.scopusauthoridWong, AST=23987963300en_HK
dc.identifier.citeulike1298038-

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