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- Scopus: eid_2-s2.0-0028556649
- PMID: 7533009
- WOS: WOS:A1994QD99200005
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Article: Effects of oral IGF-I or IGF-II on digestive organ growth in newborn piglets
Title | Effects of oral IGF-I or IGF-II on digestive organ growth in newborn piglets |
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Authors | |
Keywords | Gut growth IGF-I IGF-II Intestinal development Newborn pigs |
Issue Date | 1994 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/BON |
Citation | Biology Of The Neonate, 1994, v. 66 n. 5, p. 280-287 How to Cite? |
Abstract | To study whether colostrum-borne growth factors are responsible for the rapid GI tissue growth in naturally suckled newborn animals, newborn unsuckled piglets were bottle-fed for 24 h with infant milk formula with or without addition of 2 μg/ml of recombinant human insulin-like growth factor-I (IGF-I) or insulin-like growth factor-II (IGF-II), a level which approximated that of porcine colostrum. The animals were then sacrificed for measurements of their digestive organ weights and contents of protein, RNA and DNA in the organs. The treatment with IGF-I or IGF-II failed to show any significant effect on the weight of the esophagus, stomach, small intestine, large intestine, mandibular glands, kidneys and the spleen, and had no effects on the contents of protein, RNA and DNA in the small intestinal mucosa, the liver and the spleen. However, piglets fed with infant formula containing IGF-I (n = 7) or IGF-II (n = 7) had a heavier pancreas (p < 0.05) compared to fommula-fed controls (n = 7). The DNA content in the stomach and the pancreas were greater in animals treated with IGF-I or IGF-II than in controls. Using a cell labelling technique it was shown that both IGF-I and IGF-II stimulated cell proliferation in the small intestinal crypts. The results indicate that the substantial GI tissue growth reported in newborn animals is unlikely due to colostrum-borne IGF-I or IGF-II alone. On the other hand the study does suggest that oral IGF-I and IGF-II are capable of stimulating cell proliferation in the GI tract. |
Persistent Identifier | http://hdl.handle.net/10722/84826 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xu, RJ | en_HK |
dc.contributor.author | Mellor, DJ | en_HK |
dc.contributor.author | Birtles, MJ | en_HK |
dc.contributor.author | Breier, BH | en_HK |
dc.contributor.author | Gluckman, PD | en_HK |
dc.date.accessioned | 2010-09-06T08:57:34Z | - |
dc.date.available | 2010-09-06T08:57:34Z | - |
dc.date.issued | 1994 | en_HK |
dc.identifier.citation | Biology Of The Neonate, 1994, v. 66 n. 5, p. 280-287 | en_HK |
dc.identifier.issn | 0006-3126 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/84826 | - |
dc.description.abstract | To study whether colostrum-borne growth factors are responsible for the rapid GI tissue growth in naturally suckled newborn animals, newborn unsuckled piglets were bottle-fed for 24 h with infant milk formula with or without addition of 2 μg/ml of recombinant human insulin-like growth factor-I (IGF-I) or insulin-like growth factor-II (IGF-II), a level which approximated that of porcine colostrum. The animals were then sacrificed for measurements of their digestive organ weights and contents of protein, RNA and DNA in the organs. The treatment with IGF-I or IGF-II failed to show any significant effect on the weight of the esophagus, stomach, small intestine, large intestine, mandibular glands, kidneys and the spleen, and had no effects on the contents of protein, RNA and DNA in the small intestinal mucosa, the liver and the spleen. However, piglets fed with infant formula containing IGF-I (n = 7) or IGF-II (n = 7) had a heavier pancreas (p < 0.05) compared to fommula-fed controls (n = 7). The DNA content in the stomach and the pancreas were greater in animals treated with IGF-I or IGF-II than in controls. Using a cell labelling technique it was shown that both IGF-I and IGF-II stimulated cell proliferation in the small intestinal crypts. The results indicate that the substantial GI tissue growth reported in newborn animals is unlikely due to colostrum-borne IGF-I or IGF-II alone. On the other hand the study does suggest that oral IGF-I and IGF-II are capable of stimulating cell proliferation in the GI tract. | en_HK |
dc.language | eng | en_HK |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/BON | en_HK |
dc.relation.ispartof | Biology of the Neonate | en_HK |
dc.rights | Biology of the Neonate. Copyright © S Karger AG. | en_HK |
dc.subject | Gut growth | en_HK |
dc.subject | IGF-I | en_HK |
dc.subject | IGF-II | en_HK |
dc.subject | Intestinal development | en_HK |
dc.subject | Newborn pigs | en_HK |
dc.title | Effects of oral IGF-I or IGF-II on digestive organ growth in newborn piglets | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3126&volume=66&spage=280&epage=287&date=1994&atitle=Effects+of+oral+IGF-I+or+IGF-II+on+digestive+organ+growth+in+newborn+piglets. | en_HK |
dc.identifier.email | Xu, RJ: xuruojun@hkucc.hku.hk | en_HK |
dc.identifier.authority | Xu, RJ=rp00820 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 7533009 | - |
dc.identifier.scopus | eid_2-s2.0-0028556649 | en_HK |
dc.identifier.hkuros | 5791 | en_HK |
dc.identifier.volume | 66 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 280 | en_HK |
dc.identifier.epage | 287 | en_HK |
dc.identifier.isi | WOS:A1994QD99200005 | - |
dc.publisher.place | Switzerland | en_HK |
dc.identifier.scopusauthorid | Xu, RJ=7402813973 | en_HK |
dc.identifier.scopusauthorid | Mellor, DJ=7103269442 | en_HK |
dc.identifier.scopusauthorid | Birtles, MJ=6603615393 | en_HK |
dc.identifier.scopusauthorid | Breier, BH=7004417919 | en_HK |
dc.identifier.scopusauthorid | Gluckman, PD=7102140423 | en_HK |
dc.identifier.issnl | 0006-3126 | - |