File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effects of oral IGF-I or IGF-II on digestive organ growth in newborn piglets

TitleEffects of oral IGF-I or IGF-II on digestive organ growth in newborn piglets
Authors
KeywordsGut growth
IGF-I
IGF-II
Intestinal development
Newborn pigs
Issue Date1994
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/BON
Citation
Biology Of The Neonate, 1994, v. 66 n. 5, p. 280-287 How to Cite?
AbstractTo study whether colostrum-borne growth factors are responsible for the rapid GI tissue growth in naturally suckled newborn animals, newborn unsuckled piglets were bottle-fed for 24 h with infant milk formula with or without addition of 2 μg/ml of recombinant human insulin-like growth factor-I (IGF-I) or insulin-like growth factor-II (IGF-II), a level which approximated that of porcine colostrum. The animals were then sacrificed for measurements of their digestive organ weights and contents of protein, RNA and DNA in the organs. The treatment with IGF-I or IGF-II failed to show any significant effect on the weight of the esophagus, stomach, small intestine, large intestine, mandibular glands, kidneys and the spleen, and had no effects on the contents of protein, RNA and DNA in the small intestinal mucosa, the liver and the spleen. However, piglets fed with infant formula containing IGF-I (n = 7) or IGF-II (n = 7) had a heavier pancreas (p < 0.05) compared to fommula-fed controls (n = 7). The DNA content in the stomach and the pancreas were greater in animals treated with IGF-I or IGF-II than in controls. Using a cell labelling technique it was shown that both IGF-I and IGF-II stimulated cell proliferation in the small intestinal crypts. The results indicate that the substantial GI tissue growth reported in newborn animals is unlikely due to colostrum-borne IGF-I or IGF-II alone. On the other hand the study does suggest that oral IGF-I and IGF-II are capable of stimulating cell proliferation in the GI tract.
Persistent Identifierhttp://hdl.handle.net/10722/84826
ISSN
2008 Impact Factor: 1.741
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXu, RJen_HK
dc.contributor.authorMellor, DJen_HK
dc.contributor.authorBirtles, MJen_HK
dc.contributor.authorBreier, BHen_HK
dc.contributor.authorGluckman, PDen_HK
dc.date.accessioned2010-09-06T08:57:34Z-
dc.date.available2010-09-06T08:57:34Z-
dc.date.issued1994en_HK
dc.identifier.citationBiology Of The Neonate, 1994, v. 66 n. 5, p. 280-287en_HK
dc.identifier.issn0006-3126en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84826-
dc.description.abstractTo study whether colostrum-borne growth factors are responsible for the rapid GI tissue growth in naturally suckled newborn animals, newborn unsuckled piglets were bottle-fed for 24 h with infant milk formula with or without addition of 2 μg/ml of recombinant human insulin-like growth factor-I (IGF-I) or insulin-like growth factor-II (IGF-II), a level which approximated that of porcine colostrum. The animals were then sacrificed for measurements of their digestive organ weights and contents of protein, RNA and DNA in the organs. The treatment with IGF-I or IGF-II failed to show any significant effect on the weight of the esophagus, stomach, small intestine, large intestine, mandibular glands, kidneys and the spleen, and had no effects on the contents of protein, RNA and DNA in the small intestinal mucosa, the liver and the spleen. However, piglets fed with infant formula containing IGF-I (n = 7) or IGF-II (n = 7) had a heavier pancreas (p < 0.05) compared to fommula-fed controls (n = 7). The DNA content in the stomach and the pancreas were greater in animals treated with IGF-I or IGF-II than in controls. Using a cell labelling technique it was shown that both IGF-I and IGF-II stimulated cell proliferation in the small intestinal crypts. The results indicate that the substantial GI tissue growth reported in newborn animals is unlikely due to colostrum-borne IGF-I or IGF-II alone. On the other hand the study does suggest that oral IGF-I and IGF-II are capable of stimulating cell proliferation in the GI tract.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/BONen_HK
dc.relation.ispartofBiology of the Neonateen_HK
dc.rightsBiology of the Neonate. Copyright © S Karger AG.en_HK
dc.subjectGut growthen_HK
dc.subjectIGF-Ien_HK
dc.subjectIGF-IIen_HK
dc.subjectIntestinal developmenten_HK
dc.subjectNewborn pigsen_HK
dc.titleEffects of oral IGF-I or IGF-II on digestive organ growth in newborn pigletsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3126&volume=66&spage=280&epage=287&date=1994&atitle=Effects+of+oral+IGF-I+or+IGF-II+on+digestive+organ+growth+in+newborn+piglets.en_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7533009-
dc.identifier.scopuseid_2-s2.0-0028556649en_HK
dc.identifier.hkuros5791en_HK
dc.identifier.volume66en_HK
dc.identifier.issue5en_HK
dc.identifier.spage280en_HK
dc.identifier.epage287en_HK
dc.identifier.isiWOS:A1994QD99200005-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK
dc.identifier.scopusauthoridMellor, DJ=7103269442en_HK
dc.identifier.scopusauthoridBirtles, MJ=6603615393en_HK
dc.identifier.scopusauthoridBreier, BH=7004417919en_HK
dc.identifier.scopusauthoridGluckman, PD=7102140423en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats