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Article: Stability of gastrin in the gastrointestinal lumen of suckling, weanling and adult pigs

TitleStability of gastrin in the gastrointestinal lumen of suckling, weanling and adult pigs
Authors
KeywordsGastrin
Gut development, pig
Luminal digestion
Issue Date1996
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/BON
Citation
Biology Of The Neonate, 1996, v. 70 n. 1, p. 60-68 How to Cite?
AbstractIt has been reported in the literature that a large quantity of gastrin is released into the gastric lumen in various species. This study was aimed to examine the stability of gastrin in the gastrointestinal (GI) lumen of pigs. Iodine-labelled little (G17) and big gastrin (G34) were incubated in vitro with the GI luminal fluids of suckling, weanling and adult pigs at 37°C for 20 min, and the degradation of the peptide was measured by monitoring the generation of trichloroacetic acid soluble radioactivity. The degradation rate of G17 in the gastric fluids of all animals was less than 10%, while the degradation of G34 was less than 15% in the gastric fluids of suckling and adult pigs and about 25% in the gastric fluids of weanling pigs. The degradation rates of G17 and G34 in the small intestinal fluids of suckling pigs were between 18 and 30%, and were significantly lower than the corresponding rates in the intestinal fluids of weanling and adult pigs, the latter were between 35 and 67%. Addition of defatted porcine colostrum or its components, the casein or acid-soluble fraction, inhibited gastrin degradation in the intestinal fluids with the casein fraction having highest inhibition potency. These results indicate that gastrin is stable in the GI lumen of the suckling pigs and porcine colostrum protects gastrin from luminal hydrolysis in the small intestine, suggesting a potential physiological role of luminally released gastrin in suckling animals.
Persistent Identifierhttp://hdl.handle.net/10722/84823
ISSN
2008 Impact Factor: 1.741
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, RJen_HK
dc.contributor.authorMao, YLen_HK
dc.contributor.authorTso, MYWen_HK
dc.date.accessioned2010-09-06T08:57:32Z-
dc.date.available2010-09-06T08:57:32Z-
dc.date.issued1996en_HK
dc.identifier.citationBiology Of The Neonate, 1996, v. 70 n. 1, p. 60-68en_HK
dc.identifier.issn0006-3126en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84823-
dc.description.abstractIt has been reported in the literature that a large quantity of gastrin is released into the gastric lumen in various species. This study was aimed to examine the stability of gastrin in the gastrointestinal (GI) lumen of pigs. Iodine-labelled little (G17) and big gastrin (G34) were incubated in vitro with the GI luminal fluids of suckling, weanling and adult pigs at 37°C for 20 min, and the degradation of the peptide was measured by monitoring the generation of trichloroacetic acid soluble radioactivity. The degradation rate of G17 in the gastric fluids of all animals was less than 10%, while the degradation of G34 was less than 15% in the gastric fluids of suckling and adult pigs and about 25% in the gastric fluids of weanling pigs. The degradation rates of G17 and G34 in the small intestinal fluids of suckling pigs were between 18 and 30%, and were significantly lower than the corresponding rates in the intestinal fluids of weanling and adult pigs, the latter were between 35 and 67%. Addition of defatted porcine colostrum or its components, the casein or acid-soluble fraction, inhibited gastrin degradation in the intestinal fluids with the casein fraction having highest inhibition potency. These results indicate that gastrin is stable in the GI lumen of the suckling pigs and porcine colostrum protects gastrin from luminal hydrolysis in the small intestine, suggesting a potential physiological role of luminally released gastrin in suckling animals.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/BONen_HK
dc.relation.ispartofBiology of the Neonateen_HK
dc.rightsBiology of the Neonate. Copyright © S Karger AG.en_HK
dc.subjectGastrinen_HK
dc.subjectGut development, pigen_HK
dc.subjectLuminal digestionen_HK
dc.titleStability of gastrin in the gastrointestinal lumen of suckling, weanling and adult pigsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3126&volume=70&spage=60&epage=68&date=1996&atitle=Stability+of+gastrin+in+the+gastrointestinal+lumen+of+suckling+weanling+and+adult+pigsen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8853848-
dc.identifier.scopuseid_2-s2.0-0029797063en_HK
dc.identifier.hkuros20766en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029797063&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue1en_HK
dc.identifier.spage60en_HK
dc.identifier.epage68en_HK
dc.identifier.isiWOS:A1996VA72300008-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK
dc.identifier.scopusauthoridMao, YL=55459028400en_HK
dc.identifier.scopusauthoridTso, MYW=7102052118en_HK

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