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Article: Expression and spatial distribution of secretin and secretin receptor in human cerebellum

TitleExpression and spatial distribution of secretin and secretin receptor in human cerebellum
Authors
KeywordsHuman cerebellum
Purkinje cells
Secretin
Secretin receptor
Issue Date2005
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2005, v. 16 n. 3, p. 219-222 How to Cite?
AbstractThe expression and spatial distribution of secretin and its receptor in human cerebellum were investigated by in situ hybridization and immunohistochemical techniques. Secretin mRNAs are found in Purkinje cells whereas secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer. In addition, secretin-immunoreactivities are localized in both the soma and dendrites of Purkinje cells. These data are the first demonstration of the spatial distribution of secretin and its receptor in distinct neurons within the human cerebellum. The cellular localizations of this ligand-receptor pair are consistent with the proposed actions of secretin in the cerebellum of rodents and hence suggest that secretin also serves specific neural functions in the human cerebellum. © 2005 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/84808
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References
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DC FieldValueLanguage
dc.contributor.authorLee, SMYen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorChen, Len_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-06T08:57:21Z-
dc.date.available2010-09-06T08:57:21Z-
dc.date.issued2005en_HK
dc.identifier.citationNeuroreport, 2005, v. 16 n. 3, p. 219-222en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84808-
dc.description.abstractThe expression and spatial distribution of secretin and its receptor in human cerebellum were investigated by in situ hybridization and immunohistochemical techniques. Secretin mRNAs are found in Purkinje cells whereas secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer. In addition, secretin-immunoreactivities are localized in both the soma and dendrites of Purkinje cells. These data are the first demonstration of the spatial distribution of secretin and its receptor in distinct neurons within the human cerebellum. The cellular localizations of this ligand-receptor pair are consistent with the proposed actions of secretin in the cerebellum of rodents and hence suggest that secretin also serves specific neural functions in the human cerebellum. © 2005 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsThis is a non-final version of an article published in final form in Neuroreport, 2005, v. 16 n. 3, p. 219-222en_HK
dc.subjectHuman cerebellumen_HK
dc.subjectPurkinje cellsen_HK
dc.subjectSecretinen_HK
dc.subjectSecretin receptoren_HK
dc.subject.meshCerebellum - cytology - metabolism-
dc.subject.meshGene Expression Regulation - physiology-
dc.subject.meshPurkinje Cells - cytology - metabolism-
dc.subject.meshReceptors, Gastrointestinal Hormone - genetics - metabolism-
dc.subject.meshSecretin - genetics - metabolism-
dc.titleExpression and spatial distribution of secretin and secretin receptor in human cerebellumen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SMY: suki@hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityLee, SMY=rp01536en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00001756-200502280-00003en_HK
dc.identifier.pmid15706223-
dc.identifier.scopuseid_2-s2.0-14944344753en_HK
dc.identifier.hkuros97232en_HK
dc.identifier.hkuros136154-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14944344753&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue3en_HK
dc.identifier.spage219en_HK
dc.identifier.epage222en_HK
dc.identifier.isiWOS:000227620100003-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectSecretin as a neuropeptide-
dc.relation.projectSecretin as a neuropeptide-
dc.identifier.scopusauthoridLee, SMY=35435155600en_HK
dc.identifier.scopusauthoridYung, WH=7103137893en_HK
dc.identifier.scopusauthoridChen, L=15758988300en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

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