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Article: Pituitary growth hormone secretion in the turbot, a phylogenetically recent teleost, is regulated by a species-specific pattern of neuropeptides

TitlePituitary growth hormone secretion in the turbot, a phylogenetically recent teleost, is regulated by a species-specific pattern of neuropeptides
Authors
KeywordsFishes
Forskolin
Growth hormone
Growth hormone-releasing hormone
Phorbol esters
Pituitary adenylate cyclase-activating polypeptide
Somatostatin
Issue Date2001
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEN
Citation
Neuroendocrinology, 2001, v. 74 n. 6, p. 375-385 How to Cite?
AbstractIn mammals, growth hormone (GH) is under a dual hypothalamic control exerted by growth hormone-releasing hormone (GHRH) and somatostatin (SRIH). We investigated GH release in a pleuronectiform teleost, the turbot(Psetta maxima), using a serum-free primary culture of dispersed pituitary cells. Cells released GH for up to 12 days in culture, indicating that turbot somatotropes do not require releasing hormone for their regulation. SRIH dose-dependently inhibited GH release up to a maximal inhibitory effect of 95%. None of the potential stimulators tested induced any change in basal GH release. Also, neither forskolin, an activator of adenylate cyclase, nor phorbol ester (TPA), an activator of protein kinase C, were able to modify GH release, suggesting that spontaneous basal release already represents the maximal secretory capacity of turbot somatotropes. In contrast, forskolin and TPA were able to increase GH release in the presence of SRIH. In this condition (coincubation with SRIH), pituitary adenylate cyclase-activating polypeptide (PACAP) stimulated GH release, whereas none of the other neuropeptides tested (GHRHs; sea bream or salmon or chicken II GnRHs; TRH; CRH) had any significant effect. These data indicate that inhibitory control by SRIH may be the basic control of GH production in teleosts and lower vertebrates, while PACAP may represent the ancestral growth hormone-releasing factor in teleosts, a role taken over in higher vertebrates by GHRH. Copyright © 2001 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/84800
ISSN
2015 Impact Factor: 2.583
2015 SCImago Journal Rankings: 1.479
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRousseau, Ken_HK
dc.contributor.authorLe Belle, Nen_HK
dc.contributor.authorPichavant, Ken_HK
dc.contributor.authorMarchelidon, Jen_HK
dc.contributor.authorChow, BKCen_HK
dc.contributor.authorBoeuf, Gen_HK
dc.contributor.authorDufour, Sen_HK
dc.date.accessioned2010-09-06T08:57:15Z-
dc.date.available2010-09-06T08:57:15Z-
dc.date.issued2001en_HK
dc.identifier.citationNeuroendocrinology, 2001, v. 74 n. 6, p. 375-385en_HK
dc.identifier.issn0028-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84800-
dc.description.abstractIn mammals, growth hormone (GH) is under a dual hypothalamic control exerted by growth hormone-releasing hormone (GHRH) and somatostatin (SRIH). We investigated GH release in a pleuronectiform teleost, the turbot(Psetta maxima), using a serum-free primary culture of dispersed pituitary cells. Cells released GH for up to 12 days in culture, indicating that turbot somatotropes do not require releasing hormone for their regulation. SRIH dose-dependently inhibited GH release up to a maximal inhibitory effect of 95%. None of the potential stimulators tested induced any change in basal GH release. Also, neither forskolin, an activator of adenylate cyclase, nor phorbol ester (TPA), an activator of protein kinase C, were able to modify GH release, suggesting that spontaneous basal release already represents the maximal secretory capacity of turbot somatotropes. In contrast, forskolin and TPA were able to increase GH release in the presence of SRIH. In this condition (coincubation with SRIH), pituitary adenylate cyclase-activating polypeptide (PACAP) stimulated GH release, whereas none of the other neuropeptides tested (GHRHs; sea bream or salmon or chicken II GnRHs; TRH; CRH) had any significant effect. These data indicate that inhibitory control by SRIH may be the basic control of GH production in teleosts and lower vertebrates, while PACAP may represent the ancestral growth hormone-releasing factor in teleosts, a role taken over in higher vertebrates by GHRH. Copyright © 2001 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NENen_HK
dc.relation.ispartofNeuroendocrinologyen_HK
dc.rightsNeuroendocrinology. Copyright © S Karger AG.en_HK
dc.subjectFishesen_HK
dc.subjectForskolinen_HK
dc.subjectGrowth hormoneen_HK
dc.subjectGrowth hormone-releasing hormoneen_HK
dc.subjectPhorbol estersen_HK
dc.subjectPituitary adenylate cyclase-activating polypeptideen_HK
dc.subjectSomatostatinen_HK
dc.titlePituitary growth hormone secretion in the turbot, a phylogenetically recent teleost, is regulated by a species-specific pattern of neuropeptidesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-3835&volume=74&spage=375&epage=385&date=2001&atitle=Pituitary+Growth+Hormone+Secretion+in+the+Turbot,+a+Phylogenetically+Recent+Teleost,+Is+Regulated+by+a+Species-Specific+Pattern+of+Neuropeptidesen_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000054704en_HK
dc.identifier.pmid11752894en_HK
dc.identifier.scopuseid_2-s2.0-0035670917en_HK
dc.identifier.hkuros65862en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035670917&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue6en_HK
dc.identifier.spage375en_HK
dc.identifier.epage385en_HK
dc.identifier.isiWOS:000173112500003-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridRousseau, K=7004488429en_HK
dc.identifier.scopusauthoridLe Belle, N=6602495092en_HK
dc.identifier.scopusauthoridPichavant, K=6602439351en_HK
dc.identifier.scopusauthoridMarchelidon, J=19035232900en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK
dc.identifier.scopusauthoridBoeuf, G=7003401721en_HK
dc.identifier.scopusauthoridDufour, S=7007009199en_HK

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