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Article: Stage-specific localization of transforming growth factor β1 and β3 and their receptors during spermatogenesis in men

TitleStage-specific localization of transforming growth factor β1 and β3 and their receptors during spermatogenesis in men
Authors
KeywordsHuman testis
Transforming growth factor
Transforming growth factor receptors
Issue Date2004
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1008-682X&site=1
Citation
Asian Journal Of Andrology, 2004, v. 6 n. 2, p. 105-109 How to Cite?
AbstractAim: To investigate the stage-specific localization of transforming growth factor (TGF) β1 and β3 during spermatogenesis in adult human testis. Methods: The localization of TGFβ1 and β3 was investigated by immunohistochemical staining method employing specific polyclonal antibodies. Results: Both TGFβ1 and β3 and their receptors were preponderant in the Leydig cells. TGFβ1 could not be detected in the seminiferous tubules. TGFβ3 and TGFβ-Receptor (R) I were mainly seen in the elongated spermatids, while TGFβ-RII in the pachytene spermatocytes and weak in the spermatogonia, spermatids and Sertoli cells. Only TGFβ-RII was detected in the Sertoli cells. TGFβ3, TGFβ-RI and TGFβ-RII showed a staining pattern dependent upon the stages of the seminiferous epithelium cycle. Conclusion: TGFβ isoforms and their receptors are present in the somatic and germ cells of the adult human testis, suggesting their involvement in the regulation of spermatogenesis. © 2004, Asian Journal of Andrology.
Persistent Identifierhttp://hdl.handle.net/10722/84797
ISSN
2015 Impact Factor: 2.644
2015 SCImago Journal Rankings: 0.879
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, YQen_HK
dc.contributor.authorHe, XZen_HK
dc.contributor.authorZhang, JSen_HK
dc.contributor.authorWang, RAen_HK
dc.contributor.authorZhou, Jen_HK
dc.contributor.authorXu, RJen_HK
dc.date.accessioned2010-09-06T08:57:13Z-
dc.date.available2010-09-06T08:57:13Z-
dc.date.issued2004en_HK
dc.identifier.citationAsian Journal Of Andrology, 2004, v. 6 n. 2, p. 105-109en_HK
dc.identifier.issn1008-682Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/84797-
dc.description.abstractAim: To investigate the stage-specific localization of transforming growth factor (TGF) β1 and β3 during spermatogenesis in adult human testis. Methods: The localization of TGFβ1 and β3 was investigated by immunohistochemical staining method employing specific polyclonal antibodies. Results: Both TGFβ1 and β3 and their receptors were preponderant in the Leydig cells. TGFβ1 could not be detected in the seminiferous tubules. TGFβ3 and TGFβ-Receptor (R) I were mainly seen in the elongated spermatids, while TGFβ-RII in the pachytene spermatocytes and weak in the spermatogonia, spermatids and Sertoli cells. Only TGFβ-RII was detected in the Sertoli cells. TGFβ3, TGFβ-RI and TGFβ-RII showed a staining pattern dependent upon the stages of the seminiferous epithelium cycle. Conclusion: TGFβ isoforms and their receptors are present in the somatic and germ cells of the adult human testis, suggesting their involvement in the regulation of spermatogenesis. © 2004, Asian Journal of Andrology.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1008-682X&site=1en_HK
dc.relation.ispartofAsian Journal of Andrologyen_HK
dc.subjectHuman testisen_HK
dc.subjectTransforming growth factoren_HK
dc.subjectTransforming growth factor receptorsen_HK
dc.titleStage-specific localization of transforming growth factor β1 and β3 and their receptors during spermatogenesis in menen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1008-682X&volume=6&issue=2&spage=105&epage=109&date=2004&atitle=Stage-specific+localization+of+transforming+growth+factor+beta+1+and+beta+3+and+their+receptors+during+spermatogenesis+in+menen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15154083-
dc.identifier.scopuseid_2-s2.0-2942687052en_HK
dc.identifier.hkuros102246en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942687052&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue2en_HK
dc.identifier.spage105en_HK
dc.identifier.epage109en_HK
dc.identifier.isiWOS:000221917800006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, YQ=7601321843en_HK
dc.identifier.scopusauthoridHe, XZ=7404408442en_HK
dc.identifier.scopusauthoridZhang, JS=7601336905en_HK
dc.identifier.scopusauthoridWang, RA=36071739300en_HK
dc.identifier.scopusauthoridZhou, J=7405550459en_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK

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