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Article: Morphological changes in the oesophagus of newborn pigs: Effects of age, diet and oral insulin-like growth factor I (IGF-I) or IGF-II

TitleMorphological changes in the oesophagus of newborn pigs: Effects of age, diet and oral insulin-like growth factor I (IGF-I) or IGF-II
Authors
Issue Date1996
PublisherC S I R O, Publishing. The Journal's web site is located at http://www.publish.csiro.au/journals/rfd
Citation
Reproduction, Fertility And Development, 1996, v. 8 n. 5, p. 903-909 How to Cite?
AbstractIt has been reported in the literature that the stomach and the intestine in newborns undergo profound growth and functional maturation during the immediate postnatal period and diet ingestion has a significant impact on these changes. The present paper examines oesophageal development in newborn pigs during the first three postnatal days and the effects of diet and oral insulin-like growth factor I (IGF-I) or IGF-II on oesophageal morphology. It was observed that marked changes, including reduction in thickness of the epithelium, accelerated proliferation and migration of basal epithelial cells and increased accumulation of mucus in the glandular cells, occurred during the first postnatal day following onset of natural suckling. Bottle-feeding with various liquid diets (i.e. porcine colostrum, bovine colostrum, bovine milk, and infant milk formula), induced marked morphological changes which were similar to those induced by natural suckling. However, bottle-feeding with water did not result in marked reduction in the thickness of the epithelium nor did it accelerate basal epithelial cell proliferation and migration. Oral IGF-I, but not IGF-II, increased basal epithelial cell proliferation up to 81%. Owing to a large inter-animal variation, the increment did not reach a significant level (P = 0.071). The results suggest that chemical constituents in the diet and physical stimulation of food ingestion, which cause sloughing off of luminal surface tissue, are two major stimuli of epithelial cell proliferation in the newborn oesophagus.
Persistent Identifierhttp://hdl.handle.net/10722/84794
ISSN
2015 Impact Factor: 2.135
2015 SCImago Journal Rankings: 0.814
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, RJen_HK
dc.date.accessioned2010-09-06T08:57:11Z-
dc.date.available2010-09-06T08:57:11Z-
dc.date.issued1996en_HK
dc.identifier.citationReproduction, Fertility And Development, 1996, v. 8 n. 5, p. 903-909en_HK
dc.identifier.issn1031-3613en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84794-
dc.description.abstractIt has been reported in the literature that the stomach and the intestine in newborns undergo profound growth and functional maturation during the immediate postnatal period and diet ingestion has a significant impact on these changes. The present paper examines oesophageal development in newborn pigs during the first three postnatal days and the effects of diet and oral insulin-like growth factor I (IGF-I) or IGF-II on oesophageal morphology. It was observed that marked changes, including reduction in thickness of the epithelium, accelerated proliferation and migration of basal epithelial cells and increased accumulation of mucus in the glandular cells, occurred during the first postnatal day following onset of natural suckling. Bottle-feeding with various liquid diets (i.e. porcine colostrum, bovine colostrum, bovine milk, and infant milk formula), induced marked morphological changes which were similar to those induced by natural suckling. However, bottle-feeding with water did not result in marked reduction in the thickness of the epithelium nor did it accelerate basal epithelial cell proliferation and migration. Oral IGF-I, but not IGF-II, increased basal epithelial cell proliferation up to 81%. Owing to a large inter-animal variation, the increment did not reach a significant level (P = 0.071). The results suggest that chemical constituents in the diet and physical stimulation of food ingestion, which cause sloughing off of luminal surface tissue, are two major stimuli of epithelial cell proliferation in the newborn oesophagus.en_HK
dc.languageengen_HK
dc.publisherC S I R O, Publishing. The Journal's web site is located at http://www.publish.csiro.au/journals/rfden_HK
dc.relation.ispartofReproduction, Fertility and Developmenten_HK
dc.subject.meshAdministration, Oralen_HK
dc.subject.meshAging - drug effects - metabolismen_HK
dc.subject.meshAnimal Nutritional Physiological Phenomenaen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshBromodeoxyuridine - metabolismen_HK
dc.subject.meshCattleen_HK
dc.subject.meshEpithelium - anatomy & histology - drug effects - growth & developmenten_HK
dc.subject.meshEsophagus - anatomy & histology - drug effects - growth & developmenten_HK
dc.subject.meshInsulin-Like Growth Factor I - administration & dosage - pharmacologyen_HK
dc.subject.meshInsulin-Like Growth Factor II - administration & dosage - pharmacologyen_HK
dc.subject.meshSwineen_HK
dc.titleMorphological changes in the oesophagus of newborn pigs: Effects of age, diet and oral insulin-like growth factor I (IGF-I) or IGF-IIen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1031-3613&volume=8&spage=903&epage=909&date=1996&atitle=Morphological+changes+in+the+oesophagus+of+newborn+pigs:+effects+of+age,+diet+and+oral+insulin-like+growth+factor+I+(IGF-I)+and+IGF-IIen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1071/RD9960903en_HK
dc.identifier.pmid8876050en_HK
dc.identifier.scopuseid_2-s2.0-0029850958en_HK
dc.identifier.hkuros21317en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029850958&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue5en_HK
dc.identifier.spage903en_HK
dc.identifier.epage909en_HK
dc.identifier.isiWOS:A1996VF18800009-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK

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