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Article: The secretin/pituitary adenylate cyclase-activating polypeptide/ vasoactive intestinal polypeptide superfamily in the central nervous system

TitleThe secretin/pituitary adenylate cyclase-activating polypeptide/ vasoactive intestinal polypeptide superfamily in the central nervous system
Authors
KeywordsCentral nervous system
Chemical structure
Neuropathological diseases
Physiological actions
Secretin/VIP/PACAP family peptides
Issue Date2006
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cnsamc
Citation
Central Nervous System Agents In Medicinal Chemistry, 2006, v. 6 n. 1, p. 27-57 How to Cite?
AbstractThe secretin/PACAP/VIP superfamily contains at least ten brain-gut peptides, including secretin, pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP), glucagon, glucagon-like peptide-1 (GLP-1), glucagon like peptide-2 (GLP-2), gastric inhibitory polypeptide (GIP), peptide histidine isoleucine (PHI) or peptide histidine methionine (PHM), and growth hormone-releasing hormone (GHRH). These peptides exhibit a wide tissue distribution in the peripheral systems, indicating their pleiotrophic actions in the body. Meanwhile, their functions in the central nervious system (CNS) have also been consolidated recently. For instance, most of these peptides have shown to serve as neurotransmitters, neuromodulators, neurotrophic factors, and/or neurohormones in the brain, and hence, their potential as novel CNS agents in treating neurological disorders including Autism, Alzheimer's disease, Parkinson's disease and HIV-associated neuronal cell death were recently exploited. In this article, recent progress in research of peptides in this family with particular emphasis on structures, their central functions and potential use in the treatment of neuronal diseases are reviewed. © 2006 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/84793
ISSN
2015 SCImago Journal Rankings: 0.487
References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChu, JYSen_HK
dc.contributor.authorLee, LTOen_HK
dc.contributor.authorSiu, FKYen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-06T08:57:11Z-
dc.date.available2010-09-06T08:57:11Z-
dc.date.issued2006en_HK
dc.identifier.citationCentral Nervous System Agents In Medicinal Chemistry, 2006, v. 6 n. 1, p. 27-57en_HK
dc.identifier.issn1871-5249en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84793-
dc.description.abstractThe secretin/PACAP/VIP superfamily contains at least ten brain-gut peptides, including secretin, pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP), glucagon, glucagon-like peptide-1 (GLP-1), glucagon like peptide-2 (GLP-2), gastric inhibitory polypeptide (GIP), peptide histidine isoleucine (PHI) or peptide histidine methionine (PHM), and growth hormone-releasing hormone (GHRH). These peptides exhibit a wide tissue distribution in the peripheral systems, indicating their pleiotrophic actions in the body. Meanwhile, their functions in the central nervious system (CNS) have also been consolidated recently. For instance, most of these peptides have shown to serve as neurotransmitters, neuromodulators, neurotrophic factors, and/or neurohormones in the brain, and hence, their potential as novel CNS agents in treating neurological disorders including Autism, Alzheimer's disease, Parkinson's disease and HIV-associated neuronal cell death were recently exploited. In this article, recent progress in research of peptides in this family with particular emphasis on structures, their central functions and potential use in the treatment of neuronal diseases are reviewed. © 2006 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cnsamcen_HK
dc.relation.ispartofCentral Nervous System Agents in Medicinal Chemistryen_HK
dc.subjectCentral nervous systemen_HK
dc.subjectChemical structureen_HK
dc.subjectNeuropathological diseasesen_HK
dc.subjectPhysiological actionsen_HK
dc.subjectSecretin/VIP/PACAP family peptidesen_HK
dc.titleThe secretin/pituitary adenylate cyclase-activating polypeptide/ vasoactive intestinal polypeptide superfamily in the central nervous systemen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1871-5249&volume=6&spage=27&epage=57&date=2006&atitle=The+Secretin/Pituitary+Adenylate+Cyclase-Activating+Polypeptide/Vasoactive+Intestinal+Polypeptide+Superfamily+in+the+Central+Nervous+Systemen_HK
dc.identifier.emailChu, JYS: hitan@graduate.hku.hken_HK
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityChu, JYS=rp00684en_HK
dc.identifier.authorityLee, LTO=rp00727en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/187152406776056546en_HK
dc.identifier.scopuseid_2-s2.0-33749262984en_HK
dc.identifier.hkuros115122en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749262984&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue1en_HK
dc.identifier.spage27en_HK
dc.identifier.epage57en_HK
dc.publisher.placeNetherlandsen_HK
dc.relation.projectSecretin: a putative neurosecretory hormone that regulates water homeostasis in the hypothalamus-pituitary-adrenal axis-
dc.relation.projectA conditional knockout animal model for secretin-
dc.identifier.scopusauthoridChu, JYS=34975209300en_HK
dc.identifier.scopusauthoridLee, LTO=8367269000en_HK
dc.identifier.scopusauthoridSiu, FKY=6701518484en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

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