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Article: The nephroprotective effects of the herbal medicine preparation, WH30+, on the chemical-induced acute and chronic renal failure in rats

TitleThe nephroprotective effects of the herbal medicine preparation, WH30+, on the chemical-induced acute and chronic renal failure in rats
Authors
KeywordsAcute renal failure
Adenine
Chinese herb preparation
Chronic renal failure
Cordyceps Sinensis
Glycerol
Rheum Palmatum
Salvia Miltiorrhiza
WH30+
Issue Date2005
PublisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtml
Citation
American Journal Of Chinese Medicine, 2005, v. 33 n. 3, p. 491-500 How to Cite?
AbstractIn this study, we evaluated the renal protective effects of a Chinese herbal preparation WH30+ in male Wistar rats with glycerol-induced acute renal failure and adenine-induced chronic renal failure. WH30+ is a Chinese herb preparation composed of Rheum Palmatum, Salvia Miltiorrhiza, Cordyceps Sinensis, Leonurus Sibiricus, Epihedium Macranthum, Radix Astragali, and Radix Codonopsis Pilosulae, which has been used to treat kidney deficiency in human. An acute renal failure and chronic renal failure rat model were introduced by glycerol injection (i.m.) and fed with adenine-excessive diet, respectively. WH30+ was administered to rats at the dose of 50 mg/kg/day from 10 days before the diseases were induced until the rats were sacrificed. A reduction in body weight (p < 0.01) was observed in rats with chronic renal failure, but there was no difference between treatment groups. However, the body weight of rats with acute renal failure without treatment was significantly lower than those treated with WH30+ (p < 0.05). Overall, serum creatinine and urea nitrogen were elevated significantly (p < 0.01) in renal failure rats compared to control. Treatment with WH30+ improved both serum creatinine and urea nitrogen slightly in both models. The WH30+-treated rats with acute renal failure had significantly (p < 0.05) greater creatinine clearance than those without treatment. The results of the study show that WH30+ is more effective in the prevention of acute renal failure than chronic renal failure. © 2005 World Scientific Publishing Company. Institute for Advanced Research in Asian Science and Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/84791
ISSN
2015 Impact Factor: 2.959
2015 SCImago Journal Rankings: 0.797
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNgai, HHYen_HK
dc.contributor.authorSit, WHen_HK
dc.contributor.authorWan, JMFen_HK
dc.date.accessioned2010-09-06T08:57:09Z-
dc.date.available2010-09-06T08:57:09Z-
dc.date.issued2005en_HK
dc.identifier.citationAmerican Journal Of Chinese Medicine, 2005, v. 33 n. 3, p. 491-500en_HK
dc.identifier.issn0192-415Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/84791-
dc.description.abstractIn this study, we evaluated the renal protective effects of a Chinese herbal preparation WH30+ in male Wistar rats with glycerol-induced acute renal failure and adenine-induced chronic renal failure. WH30+ is a Chinese herb preparation composed of Rheum Palmatum, Salvia Miltiorrhiza, Cordyceps Sinensis, Leonurus Sibiricus, Epihedium Macranthum, Radix Astragali, and Radix Codonopsis Pilosulae, which has been used to treat kidney deficiency in human. An acute renal failure and chronic renal failure rat model were introduced by glycerol injection (i.m.) and fed with adenine-excessive diet, respectively. WH30+ was administered to rats at the dose of 50 mg/kg/day from 10 days before the diseases were induced until the rats were sacrificed. A reduction in body weight (p < 0.01) was observed in rats with chronic renal failure, but there was no difference between treatment groups. However, the body weight of rats with acute renal failure without treatment was significantly lower than those treated with WH30+ (p < 0.05). Overall, serum creatinine and urea nitrogen were elevated significantly (p < 0.01) in renal failure rats compared to control. Treatment with WH30+ improved both serum creatinine and urea nitrogen slightly in both models. The WH30+-treated rats with acute renal failure had significantly (p < 0.05) greater creatinine clearance than those without treatment. The results of the study show that WH30+ is more effective in the prevention of acute renal failure than chronic renal failure. © 2005 World Scientific Publishing Company. Institute for Advanced Research in Asian Science and Medicine.en_HK
dc.languageengen_HK
dc.publisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtmlen_HK
dc.relation.ispartofAmerican Journal of Chinese Medicineen_HK
dc.subjectAcute renal failureen_HK
dc.subjectAdenineen_HK
dc.subjectChinese herb preparationen_HK
dc.subjectChronic renal failureen_HK
dc.subjectCordyceps Sinensisen_HK
dc.subjectGlycerolen_HK
dc.subjectRheum Palmatumen_HK
dc.subjectSalvia Miltiorrhizaen_HK
dc.subjectWH30+en_HK
dc.titleThe nephroprotective effects of the herbal medicine preparation, WH30+, on the chemical-induced acute and chronic renal failure in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0192-415X&volume=33&spage=491&epage=500&date=2005&atitle=The+Nephroprotective+Effects+of+the+Herbal+Medicine+Preparation,+WH30+,+on+the+Chemical-Induced+Acute+and+Chronic+Renal+Failure+in+Ratsen_HK
dc.identifier.emailWan, JMF: jmfwan@hku.hken_HK
dc.identifier.authorityWan, JMF=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1142/S0192415X05003089en_HK
dc.identifier.pmid16047565-
dc.identifier.scopuseid_2-s2.0-21344460772en_HK
dc.identifier.hkuros98895en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21344460772&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue3en_HK
dc.identifier.spage491en_HK
dc.identifier.epage500en_HK
dc.identifier.isiWOS:000230633800013-
dc.publisher.placeSingaporeen_HK
dc.identifier.scopusauthoridNgai, HHY=8528923200en_HK
dc.identifier.scopusauthoridSit, WH=8528923000en_HK
dc.identifier.scopusauthoridWan, JMF=8930305000en_HK

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