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Article: Effects of gonadotropin-releasing hormone on growth hormone secretion and gene expression in common carp pituitary

TitleEffects of gonadotropin-releasing hormone on growth hormone secretion and gene expression in common carp pituitary
Authors
KeywordsAnalog of gonadotropin-releasing hormone
Common carp
Gonadotropin-releasing hormone
Growth hormone
Growth hormone mRNA
Pituitary
Radioimmunoassay
Ribonuclease protection assay
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cbpb
Citation
Comparative Biochemistry And Physiology - B Biochemistry And Molecular Biology, 2002, v. 132 n. 2, p. 335-341 How to Cite?
AbstractUsing radioimmuno- and ribonuclease protection assays, we examined the effects of gonadotropin-releasing hormone and its analogs on the growth hormone mRNA level and growth hormone secretion in common carp (Cyprinus carpio) pituitary fragments with static incubation. After a 24 h treatment, sGnRH ([Trp7,Leu8]-LHRH) and sGnRH-A ([D-Arg6,Pro9]-LHRH) (0.1 nM-1 μM) elevated the GH mRNA level and stimulated the GH secretion in a dose-dependent manner, with a higher potency for sGnRH-A. In a time-course experiment, the function of sGnRH and sGnRH-A (10 nM) on GH secretion was observed after 6 h incubation, while no action on the GH mRNA level were noted until 12 h after treatment. Comparing mammalian GnRH, avian GnRH and piscine GnRH, sGnRH and sGnRH-A showed the highest potency in increasing GH mRNA level and GH-release, followed by cGnRH-II ([His5,Tyr8]-LHRH), and finally LHRH and LHRH-A([D-Trp6, Pro9]-LHRH). These findings, taken together, suggest that GnRH not only can influence GH release, but also play a role in the regulation of GH synthesis. © 2002 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84789
ISSN
2015 Impact Factor: 1.651
2015 SCImago Journal Rankings: 0.709
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, WSen_HK
dc.contributor.authorLin, HRen_HK
dc.contributor.authorWong, AOLen_HK
dc.date.accessioned2010-09-06T08:57:08Z-
dc.date.available2010-09-06T08:57:08Z-
dc.date.issued2002en_HK
dc.identifier.citationComparative Biochemistry And Physiology - B Biochemistry And Molecular Biology, 2002, v. 132 n. 2, p. 335-341en_HK
dc.identifier.issn1096-4959en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84789-
dc.description.abstractUsing radioimmuno- and ribonuclease protection assays, we examined the effects of gonadotropin-releasing hormone and its analogs on the growth hormone mRNA level and growth hormone secretion in common carp (Cyprinus carpio) pituitary fragments with static incubation. After a 24 h treatment, sGnRH ([Trp7,Leu8]-LHRH) and sGnRH-A ([D-Arg6,Pro9]-LHRH) (0.1 nM-1 μM) elevated the GH mRNA level and stimulated the GH secretion in a dose-dependent manner, with a higher potency for sGnRH-A. In a time-course experiment, the function of sGnRH and sGnRH-A (10 nM) on GH secretion was observed after 6 h incubation, while no action on the GH mRNA level were noted until 12 h after treatment. Comparing mammalian GnRH, avian GnRH and piscine GnRH, sGnRH and sGnRH-A showed the highest potency in increasing GH mRNA level and GH-release, followed by cGnRH-II ([His5,Tyr8]-LHRH), and finally LHRH and LHRH-A([D-Trp6, Pro9]-LHRH). These findings, taken together, suggest that GnRH not only can influence GH release, but also play a role in the regulation of GH synthesis. © 2002 Elsevier Science Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cbpben_HK
dc.relation.ispartofComparative Biochemistry and Physiology - B Biochemistry and Molecular Biologyen_HK
dc.subjectAnalog of gonadotropin-releasing hormoneen_HK
dc.subjectCommon carpen_HK
dc.subjectGonadotropin-releasing hormoneen_HK
dc.subjectGrowth hormoneen_HK
dc.subjectGrowth hormone mRNAen_HK
dc.subjectPituitaryen_HK
dc.subjectRadioimmunoassayen_HK
dc.subjectRibonuclease protection assayen_HK
dc.titleEffects of gonadotropin-releasing hormone on growth hormone secretion and gene expression in common carp pituitaryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1096-4959&volume=132&issue=2&spage=335&epage=341&date=2002&atitle=Effects+of+gonadotropin-releasing+hormone+on+growth+hormone+secretion+and+gene+expression+in+common+carp+pituitaryen_HK
dc.identifier.emailWong, AOL: olwong@hkucc.hku.hken_HK
dc.identifier.authorityWong, AOL=rp00806en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1096-4959(02)00039-8en_HK
dc.identifier.pmid12031458-
dc.identifier.scopuseid_2-s2.0-0035988656en_HK
dc.identifier.hkuros75797en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035988656&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume132en_HK
dc.identifier.issue2en_HK
dc.identifier.spage335en_HK
dc.identifier.epage341en_HK
dc.identifier.isiWOS:000176788200004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, WS=36062301700en_HK
dc.identifier.scopusauthoridLin, HR=7405571313en_HK
dc.identifier.scopusauthoridWong, AOL=7403147570en_HK

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