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Article: Molecular characterization of foot-and-mouth disease virus in Hong Kong during 2001-2002

TitleMolecular characterization of foot-and-mouth disease virus in Hong Kong during 2001-2002
Authors
KeywordsFoot-and-mouth disease virus
Phylogenetic analysis
Serotype O
VP1 gene
Issue Date2006
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0920-8569
Citation
Virus Genes, 2006, v. 32 n. 2, p. 139-143 How to Cite?
AbstractMost of the molecular epidemiological studies of foot-and-mouth disease virus (FMDV) are based on comparison of VP1 gene sequence. In this report, The nucleotide sequences of the VP1 coding region of FMDV type O strains O/HKN/3/01, O/HKN/5/01, O/HKN/12/01, O/HKN/7/02 and O/HKN/10/02, isolated from the disease outbreak that occurred in Hong Kong Special Administrative Region (Hong Kong SAR) of China during 2001-2002, were determined and compared with the sequences of other FMDVs. The results revealed that the VP1 gene of the five isolates had the same nucleotide (nt) sequences (639 nt), coding for 213 amino acids, and no changes were found either at the critical amino acid sites 144 (Val), 148 (Leu), 154 (Lys) and 208 (Pro) within the VP1 protein epitope (amino acids 140-160, 200-213), or in the amino acids 145-147 comprising the arginine-glycine-aspartic acid (RGD) sequence that is involved in the adsorption of virus to host cell. Analysis of the VP1 gene nucleotide sequence revealed that the five isolates examined were most closely related to FMDVs found in Hong Kong from 1991 to 1999 and Taiwan in 1997. Furthermore, although the critical amino acids on the antigen epitope of the prevalent Hong Kong isolates and the serotype O vaccine strain, O1/Manisa/Turkey/69, showed relative conservativeness, they were distantly related genetically, which showed that there existed variation between the prevalent Hong Kong FMDV strains and the vaccine strain. © Springer Science+Business Media, Inc. 2006.
Persistent Identifierhttp://hdl.handle.net/10722/84757
ISSN
2015 Impact Factor: 1.285
2015 SCImago Journal Rankings: 0.767
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJinding, Cen_HK
dc.contributor.authorMingqiu, Zen_HK
dc.contributor.authorHui, KHen_HK
dc.contributor.authorLeung, FCen_HK
dc.date.accessioned2010-09-06T08:56:46Z-
dc.date.available2010-09-06T08:56:46Z-
dc.date.issued2006en_HK
dc.identifier.citationVirus Genes, 2006, v. 32 n. 2, p. 139-143en_HK
dc.identifier.issn0920-8569en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84757-
dc.description.abstractMost of the molecular epidemiological studies of foot-and-mouth disease virus (FMDV) are based on comparison of VP1 gene sequence. In this report, The nucleotide sequences of the VP1 coding region of FMDV type O strains O/HKN/3/01, O/HKN/5/01, O/HKN/12/01, O/HKN/7/02 and O/HKN/10/02, isolated from the disease outbreak that occurred in Hong Kong Special Administrative Region (Hong Kong SAR) of China during 2001-2002, were determined and compared with the sequences of other FMDVs. The results revealed that the VP1 gene of the five isolates had the same nucleotide (nt) sequences (639 nt), coding for 213 amino acids, and no changes were found either at the critical amino acid sites 144 (Val), 148 (Leu), 154 (Lys) and 208 (Pro) within the VP1 protein epitope (amino acids 140-160, 200-213), or in the amino acids 145-147 comprising the arginine-glycine-aspartic acid (RGD) sequence that is involved in the adsorption of virus to host cell. Analysis of the VP1 gene nucleotide sequence revealed that the five isolates examined were most closely related to FMDVs found in Hong Kong from 1991 to 1999 and Taiwan in 1997. Furthermore, although the critical amino acids on the antigen epitope of the prevalent Hong Kong isolates and the serotype O vaccine strain, O1/Manisa/Turkey/69, showed relative conservativeness, they were distantly related genetically, which showed that there existed variation between the prevalent Hong Kong FMDV strains and the vaccine strain. © Springer Science+Business Media, Inc. 2006.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0920-8569en_HK
dc.relation.ispartofVirus Genesen_HK
dc.subjectFoot-and-mouth disease virusen_HK
dc.subjectPhylogenetic analysisen_HK
dc.subjectSerotype Oen_HK
dc.subjectVP1 geneen_HK
dc.titleMolecular characterization of foot-and-mouth disease virus in Hong Kong during 2001-2002en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-8569&volume=32&spage=139&epage=143&date=2006&atitle=Molecular+Characterization+of+Foot-and-mouth+Disease+Virus+in+Hong+Kong+During+2001-2002en_HK
dc.identifier.emailHui, KH: rkhhui@hkucc.hku.hken_HK
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityHui, KH=rp00711en_HK
dc.identifier.authorityLeung, FC=rp00731en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11262-005-6869-1en_HK
dc.identifier.pmid16604445-
dc.identifier.scopuseid_2-s2.0-33645711511en_HK
dc.identifier.hkuros122990en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645711511&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue2en_HK
dc.identifier.spage139en_HK
dc.identifier.epage143en_HK
dc.identifier.isiWOS:000236686000004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJinding, C=8304102600en_HK
dc.identifier.scopusauthoridMingqiu, Z=12805166200en_HK
dc.identifier.scopusauthoridHui, KH=7103304764en_HK
dc.identifier.scopusauthoridLeung, FC=7103078633en_HK
dc.identifier.citeulike582882-

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