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Article: Signal transduction pathways in GnRH- and dopamine D1-stimulated growth hormone secretion in the goldfish.

TitleSignal transduction pathways in GnRH- and dopamine D1-stimulated growth hormone secretion in the goldfish.
Authors
Issue Date1994
PublisherChinese Physiological Society. The Journal's web site is located at http://www.ibms.sinica.edu.tw/~cjp/welcome.html
Citation
Chinese Journal Of Physiology, 1994, v. 37 n. 3, p. 111-127 How to Cite?
AbstractIn goldfish, growth hormone (GH) secretion is regulated by multiple neuroendocrine factors. Among these regulators, gonadotropin-releasing hormone (GnRH) and dopamine (DA) are effective stimulators of GH release. The stimulatory actions of GnRH and DA are mediated by GnRH and DA D1 receptors on somatotropes, respectively. In this article, results from recent in vitro pharmacological and electrophysiological studies examining the possible involvement of extracellular Ca2+, protein kinase C, voltage-sensitive Ca2+ channels (VSCC) and phospholipase A2 in mediating GnRH-induced GH release are presented. Results from experiments investigating the possible interactions of cyclic adenosine 3',5'-monophosphate (cAMP), and extracellular Ca2+ entry through VSCC in mediating the DA D1-elicited GH response are also reported. These data were discussed in conjunction with other information available in the literature on the signal transduction mechanisms mediating GH secretion in goldfish. Based on these findings, a model for the transduction pathways integrating the initiation and maintenance of the distinct GnRH-induced and DA D1-elicited GH responses was proposed. GnRH and DA stimulate GH release via separate PKC- and cAMP-dependent mechanisms, respectively. These signalling mechanisms appear to act on distinct GH pools. PKC and cAMP subsequently activate VSCC. Ca2+ entry through VSCC plays a role in the sustained GH release response by enhancing the PKC- and cAMP-induced GH release.
Persistent Identifierhttp://hdl.handle.net/10722/84751
ISSN
2015 Impact Factor: 0.962
2015 SCImago Journal Rankings: 0.426

 

DC FieldValueLanguage
dc.contributor.authorChang, JPen_HK
dc.contributor.authorVan Goor, Fen_HK
dc.contributor.authorWong, AOen_HK
dc.contributor.authorJobin, RMen_HK
dc.contributor.authorNeumann, CMen_HK
dc.date.accessioned2010-09-06T08:56:41Z-
dc.date.available2010-09-06T08:56:41Z-
dc.date.issued1994en_HK
dc.identifier.citationChinese Journal Of Physiology, 1994, v. 37 n. 3, p. 111-127en_HK
dc.identifier.issn0304-4920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84751-
dc.description.abstractIn goldfish, growth hormone (GH) secretion is regulated by multiple neuroendocrine factors. Among these regulators, gonadotropin-releasing hormone (GnRH) and dopamine (DA) are effective stimulators of GH release. The stimulatory actions of GnRH and DA are mediated by GnRH and DA D1 receptors on somatotropes, respectively. In this article, results from recent in vitro pharmacological and electrophysiological studies examining the possible involvement of extracellular Ca2+, protein kinase C, voltage-sensitive Ca2+ channels (VSCC) and phospholipase A2 in mediating GnRH-induced GH release are presented. Results from experiments investigating the possible interactions of cyclic adenosine 3',5'-monophosphate (cAMP), and extracellular Ca2+ entry through VSCC in mediating the DA D1-elicited GH response are also reported. These data were discussed in conjunction with other information available in the literature on the signal transduction mechanisms mediating GH secretion in goldfish. Based on these findings, a model for the transduction pathways integrating the initiation and maintenance of the distinct GnRH-induced and DA D1-elicited GH responses was proposed. GnRH and DA stimulate GH release via separate PKC- and cAMP-dependent mechanisms, respectively. These signalling mechanisms appear to act on distinct GH pools. PKC and cAMP subsequently activate VSCC. Ca2+ entry through VSCC plays a role in the sustained GH release response by enhancing the PKC- and cAMP-induced GH release.en_HK
dc.languageengen_HK
dc.publisherChinese Physiological Society. The Journal's web site is located at http://www.ibms.sinica.edu.tw/~cjp/welcome.htmlen_HK
dc.relation.ispartofChinese Journal of Physiologyen_HK
dc.titleSignal transduction pathways in GnRH- and dopamine D1-stimulated growth hormone secretion in the goldfish.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-4920&volume=37&spage=111&epage=127&date=1994&atitle=Signal+transduction+pathways+in+GnRH-and+dopamine+D1-stimulated+growth+hormone+secretion+in+the+goldfishen_HK
dc.identifier.emailWong, AO: olwong@hkucc.hku.hken_HK
dc.identifier.authorityWong, AO=rp00806en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7535677-
dc.identifier.scopuseid_2-s2.0-0028725104en_HK
dc.identifier.hkuros5760en_HK
dc.identifier.volume37en_HK
dc.identifier.issue3en_HK
dc.identifier.spage111en_HK
dc.identifier.epage127en_HK
dc.publisher.placeTaiwan, Republic of Chinaen_HK
dc.identifier.scopusauthoridChang, JP=7601547649en_HK
dc.identifier.scopusauthoridVan Goor, F=35845505200en_HK
dc.identifier.scopusauthoridWong, AO=7403147570en_HK
dc.identifier.scopusauthoridJobin, RM=6701719589en_HK
dc.identifier.scopusauthoridNeumann, CM=16157956900en_HK

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