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Article: Regulation of cell junction dynamics by cytokines in the testis-A molecular and biochemical perspective

TitleRegulation of cell junction dynamics by cytokines in the testis-A molecular and biochemical perspective
Authors
KeywordsAdherens junctions
Anchoring junctions
Blood-testis barrier
Cytokines
Ectoplasmic specialization
Germ cells
Sertoli cells
Spermatogenesis
Testis
Tight junctions
Transcriptional regulation
Tubulobulbar complex
Issue Date2007
PublisherElsevier Ltd. The Journal's web site is located at BIOLOGY - BIOCHEMISTRY
Citation
Cytokine And Growth Factor Reviews, 2007, v. 18 n. 3-4, p. 299-311 How to Cite?
AbstractStudies in the past decade in the field have demonstrated the significance of cytokines in regulating epithelial and endothelial cell junctions including tight and anchoring junctions in multiple organs including the testis. There are mounting evidences in recent years that cytokines play a crucial role in the restructuring of junctions at the Sertoli-Sertoli and Sertoli-germ cell interface in the seminiferous epithelium during spermatogenesis. These earlier studies, however, were focused on the effects of cytokines in maintaining the steady-state protein levels of integral membrane proteins at the sites of the blood-testis barrier (BTB) and anchoring junctions at the Sertoli-Sertoli and Sertoli-germ cell interface, such as basal and apical ectoplasmic specialization, respectively. The molecular pathway(s) and/or mechanism(s) underlying these effects remained virtually unexplored until very recently. Herein, we summarize and provide some discussions on studies that focused on the role of cytokines in regulating junction restructuring events in epithelia from a molecular and biochemical perspective. Specifically, we use the adult rat or mouse testis as a model to highlight the significance of transcriptional and translational regulation. Specific areas of research that require further attentions are also highlighted. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84744
ISSN
2015 Impact Factor: 6.571
2015 SCImago Journal Rankings: 3.018
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLui, WYen_HK
dc.contributor.authorCheng, CYen_HK
dc.date.accessioned2010-09-06T08:56:37Z-
dc.date.available2010-09-06T08:56:37Z-
dc.date.issued2007en_HK
dc.identifier.citationCytokine And Growth Factor Reviews, 2007, v. 18 n. 3-4, p. 299-311en_HK
dc.identifier.issn1359-6101en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84744-
dc.description.abstractStudies in the past decade in the field have demonstrated the significance of cytokines in regulating epithelial and endothelial cell junctions including tight and anchoring junctions in multiple organs including the testis. There are mounting evidences in recent years that cytokines play a crucial role in the restructuring of junctions at the Sertoli-Sertoli and Sertoli-germ cell interface in the seminiferous epithelium during spermatogenesis. These earlier studies, however, were focused on the effects of cytokines in maintaining the steady-state protein levels of integral membrane proteins at the sites of the blood-testis barrier (BTB) and anchoring junctions at the Sertoli-Sertoli and Sertoli-germ cell interface, such as basal and apical ectoplasmic specialization, respectively. The molecular pathway(s) and/or mechanism(s) underlying these effects remained virtually unexplored until very recently. Herein, we summarize and provide some discussions on studies that focused on the role of cytokines in regulating junction restructuring events in epithelia from a molecular and biochemical perspective. Specifically, we use the adult rat or mouse testis as a model to highlight the significance of transcriptional and translational regulation. Specific areas of research that require further attentions are also highlighted. © 2007 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at BIOLOGY - BIOCHEMISTRYen_HK
dc.relation.ispartofCytokine and Growth Factor Reviewsen_HK
dc.rightsCytokine & Growth Factor Reviews. Copyright © Elsevier Ltd.en_HK
dc.subjectAdherens junctionsen_HK
dc.subjectAnchoring junctionsen_HK
dc.subjectBlood-testis barrieren_HK
dc.subjectCytokinesen_HK
dc.subjectEctoplasmic specializationen_HK
dc.subjectGerm cellsen_HK
dc.subjectSertoli cellsen_HK
dc.subjectSpermatogenesisen_HK
dc.subjectTestisen_HK
dc.subjectTight junctionsen_HK
dc.subjectTranscriptional regulationen_HK
dc.subjectTubulobulbar complexen_HK
dc.titleRegulation of cell junction dynamics by cytokines in the testis-A molecular and biochemical perspectiveen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-6101&volume=18&spage=299&epage=311 &date=2007&atitle=Regulation+of+cell+junction+dynamics+by+cytokines+in+the+testis+–+a+molecular+and+biochemical+perspective.en_HK
dc.identifier.emailLui, WY: wylui@hku.hken_HK
dc.identifier.authorityLui, WY=rp00756en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cytogfr.2007.04.009en_HK
dc.identifier.pmid17521954en_HK
dc.identifier.scopuseid_2-s2.0-34249986748en_HK
dc.identifier.hkuros128300en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249986748&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue3-4en_HK
dc.identifier.spage299en_HK
dc.identifier.epage311en_HK
dc.identifier.eissn1879-0305-
dc.identifier.isiWOS:000248074700010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLui, WY=35220192400en_HK
dc.identifier.scopusauthoridCheng, CY=7404797787en_HK
dc.identifier.citeulike5468952-

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