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Article: Dynamic cross-talk between cells and the extracellular matrix in the testis

TitleDynamic cross-talk between cells and the extracellular matrix in the testis
Authors
Issue Date2004
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0265-9247/
Citation
Bioessays, 2004, v. 26 n. 9, p. 978-992 How to Cite?
AbstractIn the seminiferous tubule of the mammalian testis, one type A1 spermatogonium (diploid, 2n) divides and differentiates into 256 spermatozoa (haploid, n) during spermatogenesis. To complete spermatogenesis and produce ∼150 × 106 spermatozoa each day in a healthy man, germ cells must migrate progressively across the seminiferous epithelium yet remain attach to the nourishing Sertoli cells. This active cell migration process involves precisely controlled restructuring events at the tight (TJ) and anchoring junctions at the cell-cell interface. While the hormonal events that regulate spermatogenesis by follicle-stimulating hormone and testosterone from the pituitary gland and Leydig cells, respectively, are known, less is known about the mechanism(s) that regulates junction restructuring during germ cell movement in the seminiferous epithelium. The relative position of tight (TJs) and anchoring junctions in the testis is of interest. Sertoli cell TJs that constitute the blood-testis barrier (BTB) are present side by side with anchoring junctions and are adjacent to the basement membrane. This intimate physical association with the TJs, the anchoring junctions and the basement membrane (a modified form of extracellular matrix, ECM) suggests a role for the ECM in the junction dynamics of the testis. Indeed, evidence is accumulating that ECM proteins are crucial to Sertoli cell TJ dynamics. In this review, we discuss the pivotal role of tumor necrosis factor α (TNFα) on BTB dynamics via its effects on the homeostasis of ECM proteins. In addition, discussion will also be focused on the novel findings regarding the role of non-basement-membrane-associated ECM proteins and components of focal adhesion (a cell-matrix anchoring junction type) in the regulation of junction dynamics in the testis. © 2004 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/84733
ISSN
2015 Impact Factor: 4.725
2015 SCImago Journal Rankings: 3.104
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSiu, MKYen_HK
dc.contributor.authorCheng, CYen_HK
dc.date.accessioned2010-09-06T08:56:29Z-
dc.date.available2010-09-06T08:56:29Z-
dc.date.issued2004en_HK
dc.identifier.citationBioessays, 2004, v. 26 n. 9, p. 978-992en_HK
dc.identifier.issn0265-9247en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84733-
dc.description.abstractIn the seminiferous tubule of the mammalian testis, one type A1 spermatogonium (diploid, 2n) divides and differentiates into 256 spermatozoa (haploid, n) during spermatogenesis. To complete spermatogenesis and produce ∼150 × 106 spermatozoa each day in a healthy man, germ cells must migrate progressively across the seminiferous epithelium yet remain attach to the nourishing Sertoli cells. This active cell migration process involves precisely controlled restructuring events at the tight (TJ) and anchoring junctions at the cell-cell interface. While the hormonal events that regulate spermatogenesis by follicle-stimulating hormone and testosterone from the pituitary gland and Leydig cells, respectively, are known, less is known about the mechanism(s) that regulates junction restructuring during germ cell movement in the seminiferous epithelium. The relative position of tight (TJs) and anchoring junctions in the testis is of interest. Sertoli cell TJs that constitute the blood-testis barrier (BTB) are present side by side with anchoring junctions and are adjacent to the basement membrane. This intimate physical association with the TJs, the anchoring junctions and the basement membrane (a modified form of extracellular matrix, ECM) suggests a role for the ECM in the junction dynamics of the testis. Indeed, evidence is accumulating that ECM proteins are crucial to Sertoli cell TJ dynamics. In this review, we discuss the pivotal role of tumor necrosis factor α (TNFα) on BTB dynamics via its effects on the homeostasis of ECM proteins. In addition, discussion will also be focused on the novel findings regarding the role of non-basement-membrane-associated ECM proteins and components of focal adhesion (a cell-matrix anchoring junction type) in the regulation of junction dynamics in the testis. © 2004 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0265-9247/en_HK
dc.relation.ispartofBioEssaysen_HK
dc.rightsBioessays. Copyright © John Wiley & Sons Ltd.en_HK
dc.titleDynamic cross-talk between cells and the extracellular matrix in the testisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0265-9247&volume=26&issue=9&spage=978&epage=992&date=2004&atitle=Dynamic+cross-talk+between+cells+and+the+extracellular+matrix+in+the+testisen_HK
dc.identifier.emailSiu, MKY: mkysiu@hkucc.hku.hken_HK
dc.identifier.authoritySiu, MKY=rp00275en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/bies.20099en_HK
dc.identifier.pmid15351968-
dc.identifier.scopuseid_2-s2.0-4644328373en_HK
dc.identifier.hkuros114333en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4644328373&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue9en_HK
dc.identifier.spage978en_HK
dc.identifier.epage992en_HK
dc.identifier.isiWOS:000223517500007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSiu, MKY=24924018400en_HK
dc.identifier.scopusauthoridCheng, CY=7404797787en_HK

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