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Article: Role of endocrine and growth factors on the ovarian surface epithelium

TitleRole of endocrine and growth factors on the ovarian surface epithelium
Authors
KeywordsCarcinogenesis
Growth factor
Hormone
Ovarian surface epithelium
Issue Date2007
PublisherBlackwell Publishing Asia.
Citation
Journal Of Obstetrics And Gynaecology Research, 2007, v. 33 n. 1, p. 3-16 How to Cite?
AbstractEpithelial ovarian cancer is a highly fatal disease for which prevention strategies have been limited; in part because of our poor understanding of the underlying biology of its precursor, the ovarian surface epithelium (OSE). The OSE is a single layer of flat-to-cuboidal mesothelial cells that covers the surface of the ovary. Despite its inconspicuous appearance in vivo, it is believed that OSE cells actively participate in the cyclical ovulatory rupture and repair process. The continuous rupture of the OSE at ovulation and the subsequent proliferation to repair the wound renders the cells susceptible to genetic damage and malignant transformation. As the ovary is a rich source of multiple hormones, and normal OSE and ovarian carcinomas secrete and have receptors for hormones, growth factors and cytokines, these factors are strong candidates to regulate normal OSE physiology and the transformation and progression of ovarian cancers. In particular, alterations of hormone/growth factor production and receptor expression are common in ovarian tumors. This review summarizes the current knowledge in the field of endocrinology and its relationship to the biology and pathology of the OSE. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/84731
ISSN
2015 Impact Factor: 1.091
2015 SCImago Journal Rankings: 0.521
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, ASTen_HK
dc.contributor.authorLeung, PCKen_HK
dc.date.accessioned2010-09-06T08:56:27Z-
dc.date.available2010-09-06T08:56:27Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Obstetrics And Gynaecology Research, 2007, v. 33 n. 1, p. 3-16en_HK
dc.identifier.issn1341-8076en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84731-
dc.description.abstractEpithelial ovarian cancer is a highly fatal disease for which prevention strategies have been limited; in part because of our poor understanding of the underlying biology of its precursor, the ovarian surface epithelium (OSE). The OSE is a single layer of flat-to-cuboidal mesothelial cells that covers the surface of the ovary. Despite its inconspicuous appearance in vivo, it is believed that OSE cells actively participate in the cyclical ovulatory rupture and repair process. The continuous rupture of the OSE at ovulation and the subsequent proliferation to repair the wound renders the cells susceptible to genetic damage and malignant transformation. As the ovary is a rich source of multiple hormones, and normal OSE and ovarian carcinomas secrete and have receptors for hormones, growth factors and cytokines, these factors are strong candidates to regulate normal OSE physiology and the transformation and progression of ovarian cancers. In particular, alterations of hormone/growth factor production and receptor expression are common in ovarian tumors. This review summarizes the current knowledge in the field of endocrinology and its relationship to the biology and pathology of the OSE. © 2007 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia.en_HK
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_HK
dc.subjectCarcinogenesisen_HK
dc.subjectGrowth factoren_HK
dc.subjectHormoneen_HK
dc.subjectOvarian surface epitheliumen_HK
dc.titleRole of endocrine and growth factors on the ovarian surface epitheliumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1341-8076&volume=33&spage=3&epage=16&date=2007&atitle=Role+of+endocrine+and+growth+factors+on+the+ovarian+surface+epitheliumen_HK
dc.identifier.emailWong, AST: awong1@hkucc.hku.hken_HK
dc.identifier.authorityWong, AST=rp00805en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1447-0756.2007.00478.xen_HK
dc.identifier.pmid17212660-
dc.identifier.scopuseid_2-s2.0-33845956069en_HK
dc.identifier.hkuros130199en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845956069&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue1en_HK
dc.identifier.spage3en_HK
dc.identifier.epage16en_HK
dc.identifier.isiWOS:000243023200001-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridWong, AST=23987963300en_HK
dc.identifier.scopusauthoridLeung, PCK=12782513900en_HK
dc.identifier.citeulike1012962-

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