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Article: Signaling mechanisms of secretin receptor

TitleSignaling mechanisms of secretin receptor
Authors
KeywordscAMP
IP3
Pathway
Secretin receptor
Signal transduction
Structure
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpep
Citation
Regulatory Peptides, 2006, v. 137 n. 1-2, p. 95-104 How to Cite?
AbstractSecretin, a 27-amino acid gastrointestinal peptide, was initially discovered based on its activities in stimulating pancreatic juice. In the past 20 years, secretin was demonstrated to exhibit pleiotropic functions in many different tissues and more importantly, its role as a neuropeptide was substantiated. To carry out its activities in the central nervous system and in peripheral organs, secretin interacts specifically with one known receptor. Secretin receptor, a member of guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) in the secretin/VIP/glucagon subfamily, possesses the characteristics of GPCR with seven conserved transmembrane domains, a relatively large amino-terminal extracellular domain and an intracellular carboxyl terminus. The structural features and signal transduction pathways of the secretin receptor in various tissues are reviewed in this article. © 2006 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84726
ISSN
2015 Impact Factor: 1.813
2015 SCImago Journal Rankings: 0.915
ISI Accession Number ID
References
Grants

 

DC FieldValueLanguage
dc.contributor.authorSiu, FKYen_HK
dc.contributor.authorLam, IPYen_HK
dc.contributor.authorChu, JYSen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-06T08:56:24Z-
dc.date.available2010-09-06T08:56:24Z-
dc.date.issued2006en_HK
dc.identifier.citationRegulatory Peptides, 2006, v. 137 n. 1-2, p. 95-104en_HK
dc.identifier.issn0167-0115en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84726-
dc.description.abstractSecretin, a 27-amino acid gastrointestinal peptide, was initially discovered based on its activities in stimulating pancreatic juice. In the past 20 years, secretin was demonstrated to exhibit pleiotropic functions in many different tissues and more importantly, its role as a neuropeptide was substantiated. To carry out its activities in the central nervous system and in peripheral organs, secretin interacts specifically with one known receptor. Secretin receptor, a member of guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) in the secretin/VIP/glucagon subfamily, possesses the characteristics of GPCR with seven conserved transmembrane domains, a relatively large amino-terminal extracellular domain and an intracellular carboxyl terminus. The structural features and signal transduction pathways of the secretin receptor in various tissues are reviewed in this article. © 2006 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpepen_HK
dc.relation.ispartofRegulatory Peptidesen_HK
dc.rightsRegulatory Peptides. Copyright © Elsevier BV.en_HK
dc.subjectcAMPen_HK
dc.subjectIP3en_HK
dc.subjectPathwayen_HK
dc.subjectSecretin receptoren_HK
dc.subjectSignal transductionen_HK
dc.subjectStructureen_HK
dc.titleSignaling mechanisms of secretin receptoren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0167-0115&volume=137&spage=95&epage=104&date=2006&atitle=Signaling+mechanisms+of+secretin+receptor.en_HK
dc.identifier.emailChu, JYS: hitan@graduate.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityChu, JYS=rp00684en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.regpep.2006.02.011en_HK
dc.identifier.pmid16930743-
dc.identifier.scopuseid_2-s2.0-33750976173en_HK
dc.identifier.hkuros125070en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750976173&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume137en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage95en_HK
dc.identifier.epage104en_HK
dc.identifier.isiWOS:000242881700013-
dc.publisher.placeNetherlandsen_HK
dc.relation.projectSecretin: a putative neurosecretory hormone that regulates water homeostasis in the hypothalamus-pituitary-adrenal axis-
dc.relation.projectA conditional knockout animal model for secretin-
dc.identifier.scopusauthoridSiu, FKY=6701518484en_HK
dc.identifier.scopusauthoridLam, IPY=14050702700en_HK
dc.identifier.scopusauthoridChu, JYS=34975209300en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

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