File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1

TitleRetinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1
Authors
KeywordsCdk1
Promotor
Retinoic acid
Secretin
Issue Date2006
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1
Citation
Annals Of The New York Academy Of Sciences, 2006, v. 1070, p. 393-398 How to Cite?
AbstractPreviously, we found that secretin transcript levels were induced by all-trans retinoic acid (RA) in a neuroblastoma cell model, SH-SY5Y. In this article, this RA-dependent upregulation process was further investigated. In the cyclin-dependent kinase 1 (Cdk1) inhibitor-treated cells, the RA-dependent induction of secretin gene expression was inhibited. Together with our previous works, we propose here that the RA responsiveness of the secretin promotor is mediated by two different pathways. The first pathway is by changing the expression levels of NFI-C and Sp proteins while the second pathway is by modifying the phosphorylation status of both NFI-C and Sp proteins via Cdk1. © 2006 New York Academy of Sciences.
Persistent Identifierhttp://hdl.handle.net/10722/84708
ISSN
2015 Impact Factor: 4.518
2015 SCImago Journal Rankings: 2.389
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, LTOen_HK
dc.contributor.authorTanUn, KCen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-06T08:56:12Z-
dc.date.available2010-09-06T08:56:12Z-
dc.date.issued2006en_HK
dc.identifier.citationAnnals Of The New York Academy Of Sciences, 2006, v. 1070, p. 393-398en_HK
dc.identifier.issn0077-8923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84708-
dc.description.abstractPreviously, we found that secretin transcript levels were induced by all-trans retinoic acid (RA) in a neuroblastoma cell model, SH-SY5Y. In this article, this RA-dependent upregulation process was further investigated. In the cyclin-dependent kinase 1 (Cdk1) inhibitor-treated cells, the RA-dependent induction of secretin gene expression was inhibited. Together with our previous works, we propose here that the RA responsiveness of the secretin promotor is mediated by two different pathways. The first pathway is by changing the expression levels of NFI-C and Sp proteins while the second pathway is by modifying the phosphorylation status of both NFI-C and Sp proteins via Cdk1. © 2006 New York Academy of Sciences.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1en_HK
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_HK
dc.subjectCdk1en_HK
dc.subjectPromotoren_HK
dc.subjectRetinoic aciden_HK
dc.subjectSecretinen_HK
dc.titleRetinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0077-8923&volume=1070&spage=393&epage=398&date=2006&atitle=Retinoic+acid-induced+human+secretin+gene+expression+in+neuronal+cells+is+mediated+by+cyclin-dependent+kinase+1en_HK
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_HK
dc.identifier.emailTanUn, KC: kctanun@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityLee, LTO=rp00727en_HK
dc.identifier.authorityTanUn, KC=rp00787en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1196/annals.1317.051en_HK
dc.identifier.pmid16888198-
dc.identifier.scopuseid_2-s2.0-33746451220en_HK
dc.identifier.hkuros122695en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746451220&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1070en_HK
dc.identifier.spage393en_HK
dc.identifier.epage398en_HK
dc.identifier.isiWOS:000240364200055-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLee, LTO=8367269000en_HK
dc.identifier.scopusauthoridTanUn, KC=6602914262en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats