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Article: Oral insulinlike growth factor-I stimulates intestinal enzyme maturation in newborn rats

TitleOral insulinlike growth factor-I stimulates intestinal enzyme maturation in newborn rats
Authors
KeywordsHydrocortisone
IGF-I milk
Intestinal development
Newborn rats
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1997, v. 61 n. 1, p. 51-58 How to Cite?
AbstractInsulinlike growth factor-I (IGF-I) has been found in the milk of various species. To investigate if milk-borne IGF-I has any effect on postnatal gut development in neonatal animals, newborn rat pups were given orally 1 μg recombinant human IGF-I daily for 3 days For comparison, a separate group of newborn pups was given 150 μg hydrocortisone, the hormone known to stimulate intestinal maturation in neonatal rats. Oral IGF-I treatment had no significant effect on the animal body weight nor on the weight of the stomach, small and large intestines, and pancreas Oral administration of hydrocortisone significantly reduced body weight gain, but it had no apparent effect on internal organ weights. Both IGF-I and hydrocortisone treatments, however, significantly increased lactase, maltase and sucrase activities and hydrocortisone significantly increased aminopeptidase activity at the proximal small intestine when compared with the control. The finding supports the hypothesis that milkborne IGF-I may play a role in regulating postnatal gut development in the suckling young.
Persistent Identifierhttp://hdl.handle.net/10722/84702
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, Len_HK
dc.contributor.authorXu, RJen_HK
dc.date.accessioned2010-09-06T08:56:07Z-
dc.date.available2010-09-06T08:56:07Z-
dc.date.issued1997en_HK
dc.identifier.citationLife Sciences, 1997, v. 61 n. 1, p. 51-58en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84702-
dc.description.abstractInsulinlike growth factor-I (IGF-I) has been found in the milk of various species. To investigate if milk-borne IGF-I has any effect on postnatal gut development in neonatal animals, newborn rat pups were given orally 1 μg recombinant human IGF-I daily for 3 days For comparison, a separate group of newborn pups was given 150 μg hydrocortisone, the hormone known to stimulate intestinal maturation in neonatal rats. Oral IGF-I treatment had no significant effect on the animal body weight nor on the weight of the stomach, small and large intestines, and pancreas Oral administration of hydrocortisone significantly reduced body weight gain, but it had no apparent effect on internal organ weights. Both IGF-I and hydrocortisone treatments, however, significantly increased lactase, maltase and sucrase activities and hydrocortisone significantly increased aminopeptidase activity at the proximal small intestine when compared with the control. The finding supports the hypothesis that milkborne IGF-I may play a role in regulating postnatal gut development in the suckling young.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectHydrocortisoneen_HK
dc.subjectIGF-I milken_HK
dc.subjectIntestinal developmenten_HK
dc.subjectNewborn ratsen_HK
dc.titleOral insulinlike growth factor-I stimulates intestinal enzyme maturation in newborn ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=61&spage=51&epage=58&date=1997&atitle=Oral+insulinlike+growth+factor-I+stimulates+intestinal+enzyme+maturation+in+newborn+ratsen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(97)00357-3en_HK
dc.identifier.pmid9200669-
dc.identifier.scopuseid_2-s2.0-0030803079en_HK
dc.identifier.hkuros22562en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030803079&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue1en_HK
dc.identifier.spage51en_HK
dc.identifier.epage58en_HK
dc.identifier.isiWOS:A1997XC73800007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMa, L=36072648200en_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK

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