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Article: DHA depletion in rat brain is associated with impairment on spatial learning and memory

TitleDHA depletion in rat brain is associated with impairment on spatial learning and memory
Authors
KeywordsDocosahexaenoic acid
Memory
Morris water maze
Spatial learning
Issue Date2006
PublisherZhongguo Yufang Yixue Kexueyuan. The Journal's web site is located at Biomedical and Environmental Sciences
Citation
Biomedical And Environmental Sciences, 2006, v. 19 n. 6, p. 474-480 How to Cite?
AbstractObjective: To examine the effect of docosahexaenoic acid (DHA) deficiency in brain on spatial learning and memory in rats. Methods: Sprague Dawley rats were fed with an n-3 fatty acid deficient diet for two generations to induce DHA depletion in brain. DHA in seven brain regions was analyzed using the gas-liquid chromatography. Morris water maze (MWM) was employed as an assessing index of spatial learning and memory in the n-3 fatty acid deficient adult rats of second generation. Results: Feeding an n-3 deficient diet for two generations depleted DHA differently by 39%-63% in the seven brain regions including cerebellum, medulla, hypothalamus, striatum, hippocampus, cortex and midbrain. The MWM test showed that the n-3 deficient rats took a longer time and swam a longer distance to find the escape platform than the n-3 Adq group. Conclusion: The spatial learning and memory in adult rats are partially impaired by brain DHA depletion. Copyright © 2006 by China CDC.
Persistent Identifierhttp://hdl.handle.net/10722/84701
ISSN
2015 Impact Factor: 1.906
2015 SCImago Journal Rankings: 0.603
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXiao, Yen_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorXu, RJen_HK
dc.contributor.authorChen, ZYen_HK
dc.date.accessioned2010-09-06T08:56:07Z-
dc.date.available2010-09-06T08:56:07Z-
dc.date.issued2006en_HK
dc.identifier.citationBiomedical And Environmental Sciences, 2006, v. 19 n. 6, p. 474-480en_HK
dc.identifier.issn0895-3988en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84701-
dc.description.abstractObjective: To examine the effect of docosahexaenoic acid (DHA) deficiency in brain on spatial learning and memory in rats. Methods: Sprague Dawley rats were fed with an n-3 fatty acid deficient diet for two generations to induce DHA depletion in brain. DHA in seven brain regions was analyzed using the gas-liquid chromatography. Morris water maze (MWM) was employed as an assessing index of spatial learning and memory in the n-3 fatty acid deficient adult rats of second generation. Results: Feeding an n-3 deficient diet for two generations depleted DHA differently by 39%-63% in the seven brain regions including cerebellum, medulla, hypothalamus, striatum, hippocampus, cortex and midbrain. The MWM test showed that the n-3 deficient rats took a longer time and swam a longer distance to find the escape platform than the n-3 Adq group. Conclusion: The spatial learning and memory in adult rats are partially impaired by brain DHA depletion. Copyright © 2006 by China CDC.en_HK
dc.languageengen_HK
dc.publisherZhongguo Yufang Yixue Kexueyuan. The Journal's web site is located at Biomedical and Environmental Sciencesen_HK
dc.relation.ispartofBiomedical and Environmental Sciencesen_HK
dc.subjectDocosahexaenoic aciden_HK
dc.subjectMemoryen_HK
dc.subjectMorris water mazeen_HK
dc.subjectSpatial learningen_HK
dc.titleDHA depletion in rat brain is associated with impairment on spatial learning and memoryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0895-3988&volume=19&spage=474&epage=480&date=2006&atitle=DHA+depletion+in+rat+brain+is+associated+with+impairment+on+spatial+learning+and+memoryen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17319274-
dc.identifier.scopuseid_2-s2.0-33847295289en_HK
dc.identifier.hkuros134689en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847295289&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue6en_HK
dc.identifier.spage474en_HK
dc.identifier.epage480en_HK
dc.identifier.isiWOS:000243277300012-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridXiao, Y=7403260636en_HK
dc.identifier.scopusauthoridWang, L=35486456100en_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK
dc.identifier.scopusauthoridChen, ZY=34667671500en_HK

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