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Article: Oral Insulin Stimulates Intestinal Department and Enzyme Maturation in Newborn Pigs

TitleOral Insulin Stimulates Intestinal Department and Enzyme Maturation in Newborn Pigs
Authors
Issue Date2004
PublisherChinese Academy of Agricultural Sciences. The Journal's web site is located at http://cjn.lib.hku.hk/KNS50/Navi/item.aspx?NaviID=1&BaseID=ZGNX&NaviLink=Agricultural%20Sciences%20in%20China
Citation
Agricultural Sciences in China, 2004, v. 3 n. 9, p. 707-715 How to Cite?
AbstractThe effects of oral insulin on intestinal tissue growth and brush border enzyme activitiesin newborn pigs were examined in this study. Newborn unsuckled pigs were bottle-fed for3 days with artificial milk(M), milk supplemented with 60mIUmL-1 of insulin(IM) orhydrolyzed milk(HM). Compared with newborn unsuckled pigs, piglets bottle-fed for 3 daysall gained in intestinal weight and length significantly despite a mild loss in bodyweight during the experimental period. The activities of lactase and alkaline phosphatase(AKP) in the small intestinal mucosa declined markedly in pigs fed with M, but theactivity of maltase increased significantly during the experimental period. Dietaryprotein pre-hydrolysis had no significant effect on intestinal tissue mass or length,but it moderated the decline of intestinal lactase and AKP activities. Dietarysupplementation of insulin significantly increased mucosal protein content and brushborder activities of lactase, maltase, AKP and aminopeptidase(AP)in the small intestine.The effect of insulin treatment was particularly obvious at the distal region of the smallintestine. These results demonstrate that oral insulin can stimulate intestinal digestiveenzyme activities in newborn pigs. The finding supports the hypothesis that milk-borneinsulin plays a role in regulating postnatal gut development in the suckling young.
Persistent Identifierhttp://hdl.handle.net/10722/84672
ISSN
2013 Impact Factor: 0.82

 

DC FieldValueLanguage
dc.contributor.authorWang, Ten_HK
dc.contributor.authorXu, RJen_HK
dc.contributor.authorHuo, YJen_HK
dc.date.accessioned2010-09-06T08:55:46Z-
dc.date.available2010-09-06T08:55:46Z-
dc.date.issued2004en_HK
dc.identifier.citationAgricultural Sciences in China, 2004, v. 3 n. 9, p. 707-715en_HK
dc.identifier.issn1671-2927en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84672-
dc.description.abstractThe effects of oral insulin on intestinal tissue growth and brush border enzyme activitiesin newborn pigs were examined in this study. Newborn unsuckled pigs were bottle-fed for3 days with artificial milk(M), milk supplemented with 60mIUmL-1 of insulin(IM) orhydrolyzed milk(HM). Compared with newborn unsuckled pigs, piglets bottle-fed for 3 daysall gained in intestinal weight and length significantly despite a mild loss in bodyweight during the experimental period. The activities of lactase and alkaline phosphatase(AKP) in the small intestinal mucosa declined markedly in pigs fed with M, but theactivity of maltase increased significantly during the experimental period. Dietaryprotein pre-hydrolysis had no significant effect on intestinal tissue mass or length,but it moderated the decline of intestinal lactase and AKP activities. Dietarysupplementation of insulin significantly increased mucosal protein content and brushborder activities of lactase, maltase, AKP and aminopeptidase(AP)in the small intestine.The effect of insulin treatment was particularly obvious at the distal region of the smallintestine. These results demonstrate that oral insulin can stimulate intestinal digestiveenzyme activities in newborn pigs. The finding supports the hypothesis that milk-borneinsulin plays a role in regulating postnatal gut development in the suckling young.-
dc.languageengen_HK
dc.publisherChinese Academy of Agricultural Sciences. The Journal's web site is located at http://cjn.lib.hku.hk/KNS50/Navi/item.aspx?NaviID=1&BaseID=ZGNX&NaviLink=Agricultural%20Sciences%20in%20Chinaen_HK
dc.relation.ispartofAgricultural Sciences in Chinaen_HK
dc.titleOral Insulin Stimulates Intestinal Department and Enzyme Maturation in Newborn Pigsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1671-2927&volume=3 No 9&spage=707&epage=715&date=2004&atitle=Oral+insulin+stimulates+intestinal+development+and+enzyme+maturation+in+newborn+pigsen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.identifier.hkuros102247en_HK

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