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Article: A preliminary study of DNA damage in peripheral lymphocytes from lung cancer patients and healthy subjects

TitleA preliminary study of DNA damage in peripheral lymphocytes from lung cancer patients and healthy subjects
Authors
KeywordsComet assay
DNA damage
Lung cancer
Lymphocyte
Issue Date2003
PublisherScientific and Technical Research Council of Turkey - TUBITAK. The Journal's web site is located at http://journals.tubitak.gov.tr/medical/index.php
Citation
Turkish Journal Of Medical Sciences, 2003, v. 33 n. 3, p. 149-154 How to Cite?
AbstractA pilot study was undertaken to investigate the differences in oxidative DNA damage and 2-h DNA repair in peripheral lymphocytes between lung cancer patients and healthy subjects. Twenty-four lung cancer patients and 23 normal controls were recruited from the Queen Mary Hospital, Hong Kong SAR, China. Single cell gel electrophoresis (comet assay) was performed to measure the oxidative damage, repair and baseline of peripheral lymphocytes in the subjects. There were no significant differences in baseline DNA damage and oxidative stress damage and DNA repair at 2 h among the two groups of lung cancer patients who had blood taken before and those who had blood taken after chemotherapy, and normal subjects. There were no differences in basal DNA, oxidative DNA damage or DNA repair between those with and without vitamin supplements in normal subject diets. Our results demonstrated that oxidative DNA damage in lymphocytes is not associated with the risk of lung cancer.
Persistent Identifierhttp://hdl.handle.net/10722/84669
ISSN
2015 Impact Factor: 0.325
2015 SCImago Journal Rankings: 0.183
References

 

DC FieldValueLanguage
dc.contributor.authorSham, ASKen_HK
dc.contributor.authorSzeto, YTen_HK
dc.contributor.authorBenzie, IFFen_HK
dc.contributor.authorTanUn, KCen_HK
dc.date.accessioned2010-09-06T08:55:44Z-
dc.date.available2010-09-06T08:55:44Z-
dc.date.issued2003en_HK
dc.identifier.citationTurkish Journal Of Medical Sciences, 2003, v. 33 n. 3, p. 149-154en_HK
dc.identifier.issn1300-0144en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84669-
dc.description.abstractA pilot study was undertaken to investigate the differences in oxidative DNA damage and 2-h DNA repair in peripheral lymphocytes between lung cancer patients and healthy subjects. Twenty-four lung cancer patients and 23 normal controls were recruited from the Queen Mary Hospital, Hong Kong SAR, China. Single cell gel electrophoresis (comet assay) was performed to measure the oxidative damage, repair and baseline of peripheral lymphocytes in the subjects. There were no significant differences in baseline DNA damage and oxidative stress damage and DNA repair at 2 h among the two groups of lung cancer patients who had blood taken before and those who had blood taken after chemotherapy, and normal subjects. There were no differences in basal DNA, oxidative DNA damage or DNA repair between those with and without vitamin supplements in normal subject diets. Our results demonstrated that oxidative DNA damage in lymphocytes is not associated with the risk of lung cancer.en_HK
dc.languageengen_HK
dc.publisherScientific and Technical Research Council of Turkey - TUBITAK. The Journal's web site is located at http://journals.tubitak.gov.tr/medical/index.phpen_HK
dc.relation.ispartofTurkish Journal of Medical Sciencesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsA Preliminary Study of DNA Damage in Peripheral Lymphocytes from Lung Cancer Patients and Healthy Subjects by See King SHAM, Yim Tong SZETO, Iris Frances Foster BENZIE and Kian Cheng TAN-UN, Turkish Journal of Medical Sciences, v. 33 n. 3, Copyright┬ęTUBITAK 2003.-
dc.subjectComet assayen_HK
dc.subjectDNA damageen_HK
dc.subjectLung canceren_HK
dc.subjectLymphocyteen_HK
dc.titleA preliminary study of DNA damage in peripheral lymphocytes from lung cancer patients and healthy subjectsen_HK
dc.typeArticleen_HK
dc.identifier.emailTanUn, KC: kctanun@hkucc.hku.hken_HK
dc.identifier.authorityTanUn, KC=rp00787en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.scopuseid_2-s2.0-0037933360en_HK
dc.identifier.hkuros76813en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037933360&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue3en_HK
dc.identifier.spage149en_HK
dc.identifier.epage154en_HK
dc.publisher.placeTurkeyen_HK
dc.identifier.scopusauthoridSham, ASK=55225014100en_HK
dc.identifier.scopusauthoridSzeto, YT=6603749114en_HK
dc.identifier.scopusauthoridBenzie, IFF=7004481510en_HK
dc.identifier.scopusauthoridTanUn, KC=6602914262en_HK

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