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Article: Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet

TitleBitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet
Authors
KeywordsBitter melon
Free fatty acids
Glucose tolerance
Hyperinsulinemia
Rats
Visceral fat
Issue Date2003
PublisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.org
Citation
Journal Of Nutrition, 2003, v. 133 n. 4, p. 1088-1093 How to Cite?
AbstractBitter melon (BM) is known for its hypoglycemic effect but its effect on rats fed a hyperinsulinemic high fat diet has not been examined. In a dose-response (0.375, 0.75 and 1.5%) study, oral glucose tolerance was improved in rats fed a high fat (HF; 30%) diet supplemented with freeze-dried BM juice at a dose of 0.75% or higher (P < 0.05). At the highest dose, BM-supplemented rats had lower energy efficiency (P < 0.05) and tended (P = 0.10) to have less visceral fat mass. In a subsequent experiment, rats habitually fed a HF diet either continued to consume the diet or were switched to a HF+BM, low fat (LF; 7%) or LF+BM diet for 7 wk. BM was added at 0.75%. Final body weight and visceral fat mass of the two last-mentioned groups were similar to those of rats fed a LF diet for the entire duration. Rats switched to the HF+BM diet gained less weight and had less visceral fat than those fed the HF diet (P < 0.05). The addition of BM did not change apparent fat absorption. BM supplementation to the HF diet improved insulin resistance, lowered serum insulin and leptin but raised serum free fatty acid concentration (P < 0.05). This study reveals for the first time that BM reduces adiposity in rats fed a HF diet. BM appears to have multiple influences on glucose and lipid metabolism that strongly counteract the untoward effects of a high fat diet.
Persistent Identifierhttp://hdl.handle.net/10722/84655
ISSN
2015 Impact Factor: 3.74
2015 SCImago Journal Rankings: 2.040
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Qen_HK
dc.contributor.authorChan, LLYen_HK
dc.contributor.authorLi, ETSen_HK
dc.date.accessioned2010-09-06T08:55:34Z-
dc.date.available2010-09-06T08:55:34Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Nutrition, 2003, v. 133 n. 4, p. 1088-1093en_HK
dc.identifier.issn0022-3166en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84655-
dc.description.abstractBitter melon (BM) is known for its hypoglycemic effect but its effect on rats fed a hyperinsulinemic high fat diet has not been examined. In a dose-response (0.375, 0.75 and 1.5%) study, oral glucose tolerance was improved in rats fed a high fat (HF; 30%) diet supplemented with freeze-dried BM juice at a dose of 0.75% or higher (P < 0.05). At the highest dose, BM-supplemented rats had lower energy efficiency (P < 0.05) and tended (P = 0.10) to have less visceral fat mass. In a subsequent experiment, rats habitually fed a HF diet either continued to consume the diet or were switched to a HF+BM, low fat (LF; 7%) or LF+BM diet for 7 wk. BM was added at 0.75%. Final body weight and visceral fat mass of the two last-mentioned groups were similar to those of rats fed a LF diet for the entire duration. Rats switched to the HF+BM diet gained less weight and had less visceral fat than those fed the HF diet (P < 0.05). The addition of BM did not change apparent fat absorption. BM supplementation to the HF diet improved insulin resistance, lowered serum insulin and leptin but raised serum free fatty acid concentration (P < 0.05). This study reveals for the first time that BM reduces adiposity in rats fed a HF diet. BM appears to have multiple influences on glucose and lipid metabolism that strongly counteract the untoward effects of a high fat diet.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.orgen_HK
dc.relation.ispartofJournal of Nutritionen_HK
dc.subjectBitter melonen_HK
dc.subjectFree fatty acidsen_HK
dc.subjectGlucose toleranceen_HK
dc.subjectHyperinsulinemiaen_HK
dc.subjectRatsen_HK
dc.subjectVisceral faten_HK
dc.titleBitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat dieten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3166&volume=133&spage=1088&epage=1093&date=2003&atitle=Bitter+Melon+(Momordica+charantia)+Reduces+Adiposity,+Lowers+Serum+Insulin+and+Normalizes+Glucose+Tolerance+in+Rats+Fed+a+High+Fat+Dieten_HK
dc.identifier.emailLi, ETS: etsli@hku.hken_HK
dc.identifier.authorityLi, ETS=rp00737en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid12672924-
dc.identifier.scopuseid_2-s2.0-0037385896en_HK
dc.identifier.hkuros80822en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037385896&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume133en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1088en_HK
dc.identifier.epage1093en_HK
dc.identifier.isiWOS:000182036700018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, Q=55209782600en_HK
dc.identifier.scopusauthoridChan, LLY=36907180600en_HK
dc.identifier.scopusauthoridLi, ETS=14018169600en_HK

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