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Article: The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells.

TitleThe cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells.
Authors
Issue Date2005
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
Citation
Oncology Reports, 2005, v. 13 n. 6, p. 1201-1210 How to Cite?
AbstractThe polysaccharide peptide (PSP) isolated from the mycelia of Chinese Medicinal fungus Coriolus versicolor has proven benefits in clinical trials in China but the mechanism of action has not been elucidated. In this study, HL-60 cell line was used to investigate the anti-proliferation and cell death process of PSP. The cytotoxicity of PSP on normal human T-lymphocytes was also evaluated. We show that PSP induced apoptosis of human promyelocytic leukemia HL-60 cells but not of normal human T-lymphocytes. The apoptotic machinery induced by PSP was associated with a decrease in Bcl-2/Bax ratio, drop in mitochondrial transmembrane potential, cytochrome c release, and activation of caspase-3, -8 and -9. Activation of the cellular apoptotic program is a current strategy for the treatment of human cancer, and the selectivity of PSP to induce apoptosis in cancerous and not on normal cells supports its development as a novel anticancer agent.
Persistent Identifierhttp://hdl.handle.net/10722/84652
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYang, Xen_HK
dc.contributor.authorSit, WHen_HK
dc.contributor.authorChan, DKen_HK
dc.contributor.authorWan, JMen_HK
dc.date.accessioned2010-09-06T08:55:32Z-
dc.date.available2010-09-06T08:55:32Z-
dc.date.issued2005en_HK
dc.identifier.citationOncology Reports, 2005, v. 13 n. 6, p. 1201-1210en_HK
dc.identifier.issn1021-335Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/84652-
dc.description.abstractThe polysaccharide peptide (PSP) isolated from the mycelia of Chinese Medicinal fungus Coriolus versicolor has proven benefits in clinical trials in China but the mechanism of action has not been elucidated. In this study, HL-60 cell line was used to investigate the anti-proliferation and cell death process of PSP. The cytotoxicity of PSP on normal human T-lymphocytes was also evaluated. We show that PSP induced apoptosis of human promyelocytic leukemia HL-60 cells but not of normal human T-lymphocytes. The apoptotic machinery induced by PSP was associated with a decrease in Bcl-2/Bax ratio, drop in mitochondrial transmembrane potential, cytochrome c release, and activation of caspase-3, -8 and -9. Activation of the cellular apoptotic program is a current strategy for the treatment of human cancer, and the selectivity of PSP to induce apoptosis in cancerous and not on normal cells supports its development as a novel anticancer agent.en_HK
dc.languageengen_HK
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htmen_HK
dc.relation.ispartofOncology reportsen_HK
dc.titleThe cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1021-335X&volume=13&spage=1201&epage=1210&date=2005&atitle=The+cell+death+process+of+the+anticancer+agent+polysaccharide-peptide+(PSP)+in+human+promyelocytic+leukemic+HL-60+cellsen_HK
dc.identifier.emailChan, DK: chand@hku.hken_HK
dc.identifier.emailWan, JM: jmfwan@hku.hken_HK
dc.identifier.authorityChan, DK=rp00540en_HK
dc.identifier.authorityWan, JM=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15870943-
dc.identifier.scopuseid_2-s2.0-24744432974en_HK
dc.identifier.hkuros100047en_HK
dc.identifier.volume13en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1201en_HK
dc.identifier.epage1210en_HK
dc.identifier.isiWOS:000229057300030-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridYang, X=14014496500en_HK
dc.identifier.scopusauthoridSit, WH=8528923000en_HK
dc.identifier.scopusauthoridChan, DK=7402216545en_HK
dc.identifier.scopusauthoridWan, JM=8930305000en_HK

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