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Article: Gastrointestinal absorption of insulinlike growth factor-I in neonatal pigs

TitleGastrointestinal absorption of insulinlike growth factor-I in neonatal pigs
Authors
KeywordsGut closure
Milk
Peptide
Pig
Postnatal development
Issue Date1996
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jpgn.org
Citation
Journal Of Pediatric Gastroenterology And Nutrition, 1996, v. 23 n. 4, p. 430-437 How to Cite?
AbstractTo determine if milk-borne insulinlike growth factor-I (IGF-I) is absorbed in neonatal piglets, recombinant human IGF-I was iodinated and then administered via an oral-gastric tube to newborn and 3-day-old piglets together with fluorescent isothiocyanate dextran (FITC-D70s, a macromolecular marker for assessment of gut closure). Results showed that total radioactivity and trichloroacetic acid (TCA)-precipitable radioactivity rose significantly in the plasma of both newborn and 3-day-old piglets 1 hour after oral-gastric administration of 125I-IGF-I, although the magnitude of increase was greater in newborns than in 3-day-old piglets. In contrast, significant absorption of FITC-D70s was observed only in newborn piglets but not in 3-day-old piglets. Chromatographic analysis revealed that 125I- IGF-I represented up to 20% of total plasma radioactivity in the newborns and up to 10% in the 3-day-old piglets. The 125I-IGF-I found in the plasma was mostly bound to IGF-binding proteins. These results indicate that milk-borne IGF-I can be absorbed in neonatal piglets and the absorption is independent of gut closure.
Persistent Identifierhttp://hdl.handle.net/10722/84650
ISSN
2015 Impact Factor: 2.4
2015 SCImago Journal Rankings: 1.227
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, RJen_HK
dc.contributor.authorWang, Ten_HK
dc.date.accessioned2010-09-06T08:55:31Z-
dc.date.available2010-09-06T08:55:31Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Pediatric Gastroenterology And Nutrition, 1996, v. 23 n. 4, p. 430-437en_HK
dc.identifier.issn0277-2116en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84650-
dc.description.abstractTo determine if milk-borne insulinlike growth factor-I (IGF-I) is absorbed in neonatal piglets, recombinant human IGF-I was iodinated and then administered via an oral-gastric tube to newborn and 3-day-old piglets together with fluorescent isothiocyanate dextran (FITC-D70s, a macromolecular marker for assessment of gut closure). Results showed that total radioactivity and trichloroacetic acid (TCA)-precipitable radioactivity rose significantly in the plasma of both newborn and 3-day-old piglets 1 hour after oral-gastric administration of 125I-IGF-I, although the magnitude of increase was greater in newborns than in 3-day-old piglets. In contrast, significant absorption of FITC-D70s was observed only in newborn piglets but not in 3-day-old piglets. Chromatographic analysis revealed that 125I- IGF-I represented up to 20% of total plasma radioactivity in the newborns and up to 10% in the 3-day-old piglets. The 125I-IGF-I found in the plasma was mostly bound to IGF-binding proteins. These results indicate that milk-borne IGF-I can be absorbed in neonatal piglets and the absorption is independent of gut closure.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jpgn.orgen_HK
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutritionen_HK
dc.rightsJournal of Pediatric Gastroenterology and Nutrition. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectGut closureen_HK
dc.subjectMilken_HK
dc.subjectPeptideen_HK
dc.subjectPigen_HK
dc.subjectPostnatal developmenten_HK
dc.titleGastrointestinal absorption of insulinlike growth factor-I in neonatal pigsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0277-2116&volume=23&spage=430&epage=437&date=1996&atitle=Gastrointestinal+absorption+of+insulinlike+growth+factor-I+in+neonatal+pigsen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00005176-199611000-00013en_HK
dc.identifier.pmid8956182-
dc.identifier.scopuseid_2-s2.0-0030446819en_HK
dc.identifier.hkuros21290en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030446819&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue4en_HK
dc.identifier.spage430en_HK
dc.identifier.epage437en_HK
dc.identifier.isiWOS:A1996VV65200013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK
dc.identifier.scopusauthoridWang, T=7405564454en_HK

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