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Article: DNA replication time accounts for tumor growth variation induced by dietary fat in a breast carcinoma model

TitleDNA replication time accounts for tumor growth variation induced by dietary fat in a breast carcinoma model
Authors
KeywordsCell cycle
Cellular proliferation
Fish oil
Flow cytometry
Tumor promotion
Issue Date1994
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 1994, v. 86 n. 2, p. 177-186 How to Cite?
AbstractFemale Fischer rats were pair-fed on diets containing either safflower oil (SO) or fish oil (FO) for 6 weeks. Implanted breast 13762 MAT tumors had a doubling times of 35.4 and 55.5 h in SO and FO rats, respectively (P < 0.001). Proliferation kinetics were measured in vivo by bromedeoxyuridine (BrdUrd) labeling and bivariate DNA BrdUrd analysis by flow cytometry. After 1 h of pulsing, the labeling index was similar in both groups. However, 6 h later, tumor cells from FO rats had significantly lower relative movement of BrdUrd-labeled cells (0.78 vs. 0.91, P < 0.001). These results reflected a significantly longer S phase duration (15.0 vs. 9.1 h, P < 0.001) in FO rats and accounted for all the difference in tumor growth rates. This mechanism, which has not previously been reported, implies a significant role for fatty acids in DNA replication.
Persistent Identifierhttp://hdl.handle.net/10722/84642
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorIstfan, NWen_HK
dc.contributor.authorWan, JMen_HK
dc.contributor.authorBistrian, BRen_HK
dc.contributor.authorChen, ZYen_HK
dc.date.accessioned2010-09-06T08:55:25Z-
dc.date.available2010-09-06T08:55:25Z-
dc.date.issued1994en_HK
dc.identifier.citationCancer Letters, 1994, v. 86 n. 2, p. 177-186en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84642-
dc.description.abstractFemale Fischer rats were pair-fed on diets containing either safflower oil (SO) or fish oil (FO) for 6 weeks. Implanted breast 13762 MAT tumors had a doubling times of 35.4 and 55.5 h in SO and FO rats, respectively (P < 0.001). Proliferation kinetics were measured in vivo by bromedeoxyuridine (BrdUrd) labeling and bivariate DNA BrdUrd analysis by flow cytometry. After 1 h of pulsing, the labeling index was similar in both groups. However, 6 h later, tumor cells from FO rats had significantly lower relative movement of BrdUrd-labeled cells (0.78 vs. 0.91, P < 0.001). These results reflected a significantly longer S phase duration (15.0 vs. 9.1 h, P < 0.001) in FO rats and accounted for all the difference in tumor growth rates. This mechanism, which has not previously been reported, implies a significant role for fatty acids in DNA replication.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectCell cycleen_HK
dc.subjectCellular proliferationen_HK
dc.subjectFish oilen_HK
dc.subjectFlow cytometryen_HK
dc.subjectTumor promotionen_HK
dc.titleDNA replication time accounts for tumor growth variation induced by dietary fat in a breast carcinoma modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=86&spage=177&epage=186&date=1994&atitle=DNA+replication+time+accounts+for+tumor+growth+variation+induced+by+dietary+fat+in+a+breast+carcinoma+modelen_HK
dc.identifier.emailWan, JM: jmfwan@hku.hken_HK
dc.identifier.authorityWan, JM=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0304-3835(94)90076-0en_HK
dc.identifier.pmid7982205en_HK
dc.identifier.scopuseid_2-s2.0-0028100106en_HK
dc.identifier.hkuros9703en_HK
dc.identifier.volume86en_HK
dc.identifier.issue2en_HK
dc.identifier.spage177en_HK
dc.identifier.epage186en_HK
dc.identifier.isiWOS:A1994PV39800005-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridIstfan, NW=7003819779en_HK
dc.identifier.scopusauthoridWan, JM=8930305000en_HK
dc.identifier.scopusauthoridBistrian, BR=35463916700en_HK
dc.identifier.scopusauthoridChen, ZY=7409488974en_HK

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