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Article: Secretin as a neuropeptide

TitleSecretin as a neuropeptide
Authors
KeywordsAutism
Cerebellum
GABA
Inhibitory postsynaptic currents
Neuropeptide
Purkinje cells
Secretin
Issue Date2002
PublisherHumana Press, Inc.
Citation
Molecular Neurobiology, 2002, v. 26 n. 1, p. 97-107 How to Cite?
AbstractThe role of secretin as a classical hormone in the gastrointestinal system is well-established. The recent debate on the use of secretin as a potential therapeutic treatment for autistic patients urges a better understanding of the neuroactive functions of secretin. Indeed, there is an increasing body of evidence pointing to the direction that, in addition to other peptides in the secretin/glucagon superfamily, secretin is also a neuropeptide. The purpose of this review is to discuss the recent data for supporting the neurocrine roles of secretin in rodents. By in situ hybridization and immunostaining, secretin was found to be expressed in distinct neuronal populations within the cerebellum and cerebral cortex, whereas the receptor transcript was found throughout the brain. In the rat cerebellum, secretin functions as a retrograde messenger to facilitate GABA transmission, indicating that it can modulate motor and other functions. In summary, the recent data support strongly the neuropeptide role of secretin, although the secretin-autism link remains to be clarified in the future.
Persistent Identifierhttp://hdl.handle.net/10722/84641
ISSN
2015 Impact Factor: 5.397
2015 SCImago Journal Rankings: 1.819
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, SSMen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-06T08:55:25Z-
dc.date.available2010-09-06T08:55:25Z-
dc.date.issued2002en_HK
dc.identifier.citationMolecular Neurobiology, 2002, v. 26 n. 1, p. 97-107en_HK
dc.identifier.issn0893-7648en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84641-
dc.description.abstractThe role of secretin as a classical hormone in the gastrointestinal system is well-established. The recent debate on the use of secretin as a potential therapeutic treatment for autistic patients urges a better understanding of the neuroactive functions of secretin. Indeed, there is an increasing body of evidence pointing to the direction that, in addition to other peptides in the secretin/glucagon superfamily, secretin is also a neuropeptide. The purpose of this review is to discuss the recent data for supporting the neurocrine roles of secretin in rodents. By in situ hybridization and immunostaining, secretin was found to be expressed in distinct neuronal populations within the cerebellum and cerebral cortex, whereas the receptor transcript was found throughout the brain. In the rat cerebellum, secretin functions as a retrograde messenger to facilitate GABA transmission, indicating that it can modulate motor and other functions. In summary, the recent data support strongly the neuropeptide role of secretin, although the secretin-autism link remains to be clarified in the future.en_HK
dc.languageengen_HK
dc.publisherHumana Press, Inc.en_HK
dc.relation.ispartofMolecular Neurobiologyen_HK
dc.subjectAutismen_HK
dc.subjectCerebellumen_HK
dc.subjectGABAen_HK
dc.subjectInhibitory postsynaptic currentsen_HK
dc.subjectNeuropeptideen_HK
dc.subjectPurkinje cellsen_HK
dc.subjectSecretinen_HK
dc.titleSecretin as a neuropeptideen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0893-7648&volume=26&issue=1&spage=97&epage=107&date=2002&atitle=Secretin+as+a+neuropeptideen_HK
dc.identifier.emailNg, SSM: ssmng@hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityNg, SSM=rp00767en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1385/MN:26:1:097-
dc.identifier.pmid12392059-
dc.identifier.scopuseid_2-s2.0-0036700151en_HK
dc.identifier.hkuros79359en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036700151&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue1en_HK
dc.identifier.spage97en_HK
dc.identifier.epage107en_HK
dc.identifier.isiWOS:000178527500008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, SSM=7403358718en_HK
dc.identifier.scopusauthoridYung, WH=7103137893en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

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