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Article: Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells

TitleAdenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells
Authors
KeywordsApoptosis
Severe acute respiratory syndrome coronavirus
Spike protein
Virus-cell interaction
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 2005, v. 579 n. 30, p. 6699-6704 How to Cite?
AbstractThe pro-apoptotic properties of severe acute respiratory syndrome coronavirus (SARS-CoV) structural proteins were studied in vitro. By monitoring apoptosis indicators including chromatin condensation, cellular DNA fragmentation and cell membrane asymmetry, we demonstrated that the adenovirus-mediated over-expression of SARS-CoV spike (S) protein and its C-terminal domain (S2) induce apoptosis in Vero E6 cells in a time- and dosage-dependent manner, whereas the expression of its N-terminal domain (S1) and other structural proteins, including envelope (E), membrane (M) and nucleocapsid (N) protein do not. These findings suggest a possible role of S and S2 protein in SARS-CoV induced apoptosis and the molecular pathogenesis of SARS. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84628
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, KYCen_HK
dc.contributor.authorYeung, YSen_HK
dc.contributor.authorHon, CCen_HK
dc.contributor.authorZeng, Fen_HK
dc.contributor.authorLaw, KMen_HK
dc.contributor.authorLeung, FCCen_HK
dc.date.accessioned2010-09-06T08:55:15Z-
dc.date.available2010-09-06T08:55:15Z-
dc.date.issued2005en_HK
dc.identifier.citationFebs Letters, 2005, v. 579 n. 30, p. 6699-6704en_HK
dc.identifier.issn0014-5793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84628-
dc.description.abstractThe pro-apoptotic properties of severe acute respiratory syndrome coronavirus (SARS-CoV) structural proteins were studied in vitro. By monitoring apoptosis indicators including chromatin condensation, cellular DNA fragmentation and cell membrane asymmetry, we demonstrated that the adenovirus-mediated over-expression of SARS-CoV spike (S) protein and its C-terminal domain (S2) induce apoptosis in Vero E6 cells in a time- and dosage-dependent manner, whereas the expression of its N-terminal domain (S1) and other structural proteins, including envelope (E), membrane (M) and nucleocapsid (N) protein do not. These findings suggest a possible role of S and S2 protein in SARS-CoV induced apoptosis and the molecular pathogenesis of SARS. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_HK
dc.relation.ispartofFEBS Lettersen_HK
dc.rightsF E B S Letters. Copyright © Elsevier BV.en_HK
dc.subjectApoptosisen_HK
dc.subjectSevere acute respiratory syndrome coronavirusen_HK
dc.subjectSpike proteinen_HK
dc.subjectVirus-cell interactionen_HK
dc.titleAdenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-5793&volume=579&spage=6699&epage=6704&date=2005&atitle=Adenovirus-mediated+expression+of+the+C-terminal+domain+of+SARS-CoV+spike+protein+is+sufficient+to+induce+apoptosis+in+Vero+E6+cellsen_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.febslet.2005.10.065en_HK
dc.identifier.pmid16310778-
dc.identifier.scopuseid_2-s2.0-28844491800en_HK
dc.identifier.hkuros122890en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-28844491800&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume579en_HK
dc.identifier.issue30en_HK
dc.identifier.spage6699en_HK
dc.identifier.epage6704en_HK
dc.identifier.isiWOS:000234130000002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChow, KYC=7202180875en_HK
dc.identifier.scopusauthoridYeung, YS=9841205900en_HK
dc.identifier.scopusauthoridHon, CC=7003617137en_HK
dc.identifier.scopusauthoridZeng, F=7202911544en_HK
dc.identifier.scopusauthoridLaw, KM=7202563042en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK

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