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Article: The polysaccharide krestin prevents lipoperoxidative injury to experimentally atherosclerotic rabbits

TitleThe polysaccharide krestin prevents lipoperoxidative injury to experimentally atherosclerotic rabbits
Authors
KeywordsAntioxidation
Atherosclerosis
Lipoperoxidative injury
Polysaccharide krestin
Issue Date1997
PublisherChapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.html
Citation
Medical Science Research, 1997, v. 25 n. 2, p. 137-140 How to Cite?
AbstractThere is a close relationship between the development of atherosclerosis and oxidative modification of low density lipoprotein (O-LDL). Macrophage-derived foam cell formation is one of the early important pathological lesions in atherogenesis. Our previous studies have shown that lipoperoxidative injury is a major cause of transformation of macrophages into foam cells induced by O-LDL, and that polysaccharide krestin (PSK), administrated intraperitoneally to mice, could enhance selenium-dependent glutathione peroxidase (SeGSHPx) gene expression of macrophage and protect in vitro macrophage from foam cell formation caused by O-LDL. The present results show that PSK can prevent lipoperoxidative injury to the experimental atherosclerotic rabbits. The lipoperoxide (LPO) levels in the plasma, LDL and tissues (aorta, heart and liver) were much lower and the SeGSHPx activities, and especially the SeGSHPx/LPO ratios were much higher in the PSK group as compared with those in the control group. The results show that prevention of transformation of macrophages into foam cells by elevation of their antioxidation potential may be another important means of preventing the development of atherosclerosis.
Persistent Identifierhttp://hdl.handle.net/10722/84607
ISSN
2001 Impact Factor: 0.384
2003 SCImago Journal Rankings: 0.107
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Men_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorLou, Nen_HK
dc.contributor.authorLiu, Sen_HK
dc.contributor.authorPang, Zen_HK
dc.contributor.authorWan, Jen_HK
dc.date.accessioned2010-09-06T08:55:00Z-
dc.date.available2010-09-06T08:55:00Z-
dc.date.issued1997en_HK
dc.identifier.citationMedical Science Research, 1997, v. 25 n. 2, p. 137-140en_HK
dc.identifier.issn0269-8951en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84607-
dc.description.abstractThere is a close relationship between the development of atherosclerosis and oxidative modification of low density lipoprotein (O-LDL). Macrophage-derived foam cell formation is one of the early important pathological lesions in atherogenesis. Our previous studies have shown that lipoperoxidative injury is a major cause of transformation of macrophages into foam cells induced by O-LDL, and that polysaccharide krestin (PSK), administrated intraperitoneally to mice, could enhance selenium-dependent glutathione peroxidase (SeGSHPx) gene expression of macrophage and protect in vitro macrophage from foam cell formation caused by O-LDL. The present results show that PSK can prevent lipoperoxidative injury to the experimental atherosclerotic rabbits. The lipoperoxide (LPO) levels in the plasma, LDL and tissues (aorta, heart and liver) were much lower and the SeGSHPx activities, and especially the SeGSHPx/LPO ratios were much higher in the PSK group as compared with those in the control group. The results show that prevention of transformation of macrophages into foam cells by elevation of their antioxidation potential may be another important means of preventing the development of atherosclerosis.en_HK
dc.languageengen_HK
dc.publisherChapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.htmlen_HK
dc.relation.ispartofMedical Science Researchen_HK
dc.subjectAntioxidationen_HK
dc.subjectAtherosclerosisen_HK
dc.subjectLipoperoxidative injuryen_HK
dc.subjectPolysaccharide krestinen_HK
dc.titleThe polysaccharide krestin prevents lipoperoxidative injury to experimentally atherosclerotic rabbitsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-8951&volume=25&spage=137&epage=140&date=1997&atitle=The+polysaccharide+krestin+prevents+lipoperoxidative+injury+to+experimentally+atherosclerotic+rabbitsen_HK
dc.identifier.emailWan, J: jmfwan@hku.hken_HK
dc.identifier.authorityWan, J=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0030957503en_HK
dc.identifier.hkuros35643en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030957503&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue2en_HK
dc.identifier.spage137en_HK
dc.identifier.epage140en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhou, M=7403506134en_HK
dc.identifier.scopusauthoridChen, Y=16745998900en_HK
dc.identifier.scopusauthoridLou, N=7006629613en_HK
dc.identifier.scopusauthoridLiu, S=7409463469en_HK
dc.identifier.scopusauthoridPang, Z=7103343225en_HK
dc.identifier.scopusauthoridWan, J=8930305000en_HK

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