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Article: Bioactive peptides in milk and their biological and health implications

TitleBioactive peptides in milk and their biological and health implications
Authors
Issue Date1998
PublisherTaylor & Francis Inc. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/87559129.asp
Citation
Food Reviews International, 1998, v. 14 n. 1, p. 1-16 How to Cite?
AbstractMilk contains a large number of bioactive peptides with various biological activities. These peptides either exist naturally in milk or derive from milk protein hydrolyses. The natural bioactive peptides found in milk include epidermal growth factor (EGF), transforming growth factor (TGF), nerve growth factor (NGF), insulin, and insulin-like growth factors I and II (IGF-I and IGF-II). The concentrations of these peptides are generally high in colostrum, and the concentrations are often higher than those found in blood circulation. Due to a limited protease activity in the gastrointestinal tract of neonatal animals and the existence of protease inhibitors in the milk, these milk-borne bioactive peptides are likely to survive the gastrointestinal digestion in suckling animals. Oral administration of EGF, insulin, or IGF-I can stimulate gastrointestinal maturation in newborn animals. It is speculated that colostrum-borne bioactive peptides may play a role in regulating postnatal gut development in suckling neonates. The second group of bioactive peptides found in milk include casomorphins, immunostimulating peptides, and ACE-inhibitory peptides. They are built into the primary structures of milk proteins and can be released by enzymatic hydrolyses. These peptides may act as potential physiological modulators during the gastrointestinal digestion of milk.
Persistent Identifierhttp://hdl.handle.net/10722/84604
ISSN
2015 Impact Factor: 1.974
2015 SCImago Journal Rankings: 0.964
References

 

DC FieldValueLanguage
dc.contributor.authorXu, RJen_HK
dc.date.accessioned2010-09-06T08:54:58Z-
dc.date.available2010-09-06T08:54:58Z-
dc.date.issued1998en_HK
dc.identifier.citationFood Reviews International, 1998, v. 14 n. 1, p. 1-16en_HK
dc.identifier.issn8755-9129en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84604-
dc.description.abstractMilk contains a large number of bioactive peptides with various biological activities. These peptides either exist naturally in milk or derive from milk protein hydrolyses. The natural bioactive peptides found in milk include epidermal growth factor (EGF), transforming growth factor (TGF), nerve growth factor (NGF), insulin, and insulin-like growth factors I and II (IGF-I and IGF-II). The concentrations of these peptides are generally high in colostrum, and the concentrations are often higher than those found in blood circulation. Due to a limited protease activity in the gastrointestinal tract of neonatal animals and the existence of protease inhibitors in the milk, these milk-borne bioactive peptides are likely to survive the gastrointestinal digestion in suckling animals. Oral administration of EGF, insulin, or IGF-I can stimulate gastrointestinal maturation in newborn animals. It is speculated that colostrum-borne bioactive peptides may play a role in regulating postnatal gut development in suckling neonates. The second group of bioactive peptides found in milk include casomorphins, immunostimulating peptides, and ACE-inhibitory peptides. They are built into the primary structures of milk proteins and can be released by enzymatic hydrolyses. These peptides may act as potential physiological modulators during the gastrointestinal digestion of milk.en_HK
dc.languageengen_HK
dc.publisherTaylor & Francis Inc. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/87559129.aspen_HK
dc.relation.ispartofFood Reviews Internationalen_HK
dc.titleBioactive peptides in milk and their biological and health implicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=8755-9129&volume=14 &issue=1&spage=1&epage=16&date=1998&atitle=Bioactive+peptides+in+milk+and+their+biological+and+health+implicationsen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/87559129809541147-
dc.identifier.scopuseid_2-s2.0-0032222184en_HK
dc.identifier.hkuros25946en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032222184&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage16en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK

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