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Article: Deflux injection for the treatment of vesicoureteric reflux in children-a single centre's experience

TitleDeflux injection for the treatment of vesicoureteric reflux in children-a single centre's experience
Authors
KeywordsDeflux
Urology
Vesicoureteric reflux
Issue Date2009
PublisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
Citation
Asian Journal Of Surgery, 2009, v. 32 n. 3, p. 163-166 How to Cite?
AbstractBACKGROUND: Vesicoureteric reflux (VUR) is a common condition that may lead to end-staged renal failure. Treatment options include long term prophylactic antibiotics or surgical intervention. Recently, endoscopic treatment by a subureteral injection of Deflux has gained popularity. Our centre has introduced this treatment modality since 2002. METHODS: The medical records of 42 patients (15 male and 27 female) who received Deflux injections for treatment of VUR from 2002 to 2007 were reviewed. All the patients were followed up with voiding cystourethrograms at 3 months after the procedure. RESULTS: The median age at operation was 72.59 months (range, 8 to 216 months). Unilateral involvement was found in 20 patients while 22 patients had bilateral involvement. Of the 64 ureters, VUR were grade II to V in six (9.4%), 31 (48.4%), 20 (31.2%) and seven (10.9%) patients respectively. Resolution of reflux, defined as grade 0 to I, after one injection was seen in six (100%), 20 (64.5%), and 16 (80%) ureters from grade II to IV respectively. Only one patient with grade V reflux achieved complete resolution after a single injection. Of the 21 ureters which had residual reflux, three were lost from follow up and 18 (ten grade III, two grade IV and six grade V) received a second injection and eventually 12 ureters achieved resolution. Thus, the overall success rate was 67.2% after a single injection and 85.9% after two injections. No procedure-related complications was reported. CONCLUSION: Injections of Deflux is an effective treatment for VUR. A significant reduction in disease severity was seen in patients with grade II to IV disease after a single injection. Most patients with grade V disease needed more than one injection before achieving complete resolution. With this high success rate, we recommend the use of endoscopic Deflux injection as the first line treatment for children with vesicoureteric reflux disease. [Asian J Surg 2009;32(3): 163-6] © 2009 Elsevier. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84587
ISSN
2014 Impact Factor: 0.906
2013 SCImago Journal Rankings: 0.361
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChung, HYen_HK
dc.contributor.authorLan, LCLen_HK
dc.contributor.authorWong, KKYen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:54:42Z-
dc.date.available2010-09-06T08:54:42Z-
dc.date.issued2009en_HK
dc.identifier.citationAsian Journal Of Surgery, 2009, v. 32 n. 3, p. 163-166en_HK
dc.identifier.issn1015-9584en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84587-
dc.description.abstractBACKGROUND: Vesicoureteric reflux (VUR) is a common condition that may lead to end-staged renal failure. Treatment options include long term prophylactic antibiotics or surgical intervention. Recently, endoscopic treatment by a subureteral injection of Deflux has gained popularity. Our centre has introduced this treatment modality since 2002. METHODS: The medical records of 42 patients (15 male and 27 female) who received Deflux injections for treatment of VUR from 2002 to 2007 were reviewed. All the patients were followed up with voiding cystourethrograms at 3 months after the procedure. RESULTS: The median age at operation was 72.59 months (range, 8 to 216 months). Unilateral involvement was found in 20 patients while 22 patients had bilateral involvement. Of the 64 ureters, VUR were grade II to V in six (9.4%), 31 (48.4%), 20 (31.2%) and seven (10.9%) patients respectively. Resolution of reflux, defined as grade 0 to I, after one injection was seen in six (100%), 20 (64.5%), and 16 (80%) ureters from grade II to IV respectively. Only one patient with grade V reflux achieved complete resolution after a single injection. Of the 21 ureters which had residual reflux, three were lost from follow up and 18 (ten grade III, two grade IV and six grade V) received a second injection and eventually 12 ureters achieved resolution. Thus, the overall success rate was 67.2% after a single injection and 85.9% after two injections. No procedure-related complications was reported. CONCLUSION: Injections of Deflux is an effective treatment for VUR. A significant reduction in disease severity was seen in patients with grade II to IV disease after a single injection. Most patients with grade V disease needed more than one injection before achieving complete resolution. With this high success rate, we recommend the use of endoscopic Deflux injection as the first line treatment for children with vesicoureteric reflux disease. [Asian J Surg 2009;32(3): 163-6] © 2009 Elsevier. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#descriptionen_HK
dc.relation.ispartofAsian Journal of Surgeryen_HK
dc.subjectDefluxen_HK
dc.subjectUrologyen_HK
dc.subjectVesicoureteric refluxen_HK
dc.titleDeflux injection for the treatment of vesicoureteric reflux in children-a single centre's experienceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1015-9584&volume=32&issue=3&spage=163&epage=166&date=2009&atitle=Deflux+injection+for+the+treatment+of+vesicoureteric+reflux+in+children—a+single+centre%27s+experienceen_HK
dc.identifier.emailWong, KKY: kkywong@hkucc.hku.hken_HK
dc.identifier.authorityWong, KKY=rp01392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1015-9584(09)60388-2en_HK
dc.identifier.pmid19656756en_HK
dc.identifier.scopuseid_2-s2.0-70349283877en_HK
dc.identifier.hkuros160469en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349283877&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue3en_HK
dc.identifier.spage163en_HK
dc.identifier.epage166en_HK
dc.identifier.isiWOS:000269556600006-
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridChung, PHY=34568741300en_HK
dc.identifier.scopusauthoridLan, LCL=7005687228en_HK
dc.identifier.scopusauthoridWong, KKY=24438686400en_HK
dc.identifier.scopusauthoridTam, PKH=15038888000en_HK

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