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Article: Deflux injection for the treatment of vesicoureteric reflux in children-a single centre's experience
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TitleDeflux injection for the treatment of vesicoureteric reflux in children-a single centre's experience
 
AuthorsChung, PHY1
Lan, LCL1
Wong, KKY1
Tarn, PKH1
 
KeywordsDeflux
Urology
Vesicoureteric reflux
 
Issue Date2009
 
PublisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
 
CitationAsian Journal Of Surgery, 2009, v. 32 n. 3, p. 163-166 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S1015-9584(09)60388-2
 
AbstractBACKGROUND: Vesicoureteric reflux (VUR) is a common condition that may lead to end-staged renal failure. Treatment options include long term prophylactic antibiotics or surgical intervention. Recently, endoscopic treatment by a subureteral injection of Deflux has gained popularity. Our centre has introduced this treatment modality since 2002. METHODS: The medical records of 42 patients (15 male and 27 female) who received Deflux injections for treatment of VUR from 2002 to 2007 were reviewed. All the patients were followed up with voiding cystourethrograms at 3 months after the procedure. RESULTS: The median age at operation was 72.59 months (range, 8 to 216 months). Unilateral involvement was found in 20 patients while 22 patients had bilateral involvement. Of the 64 ureters, VUR were grade II to V in six (9.4%), 31 (48.4%), 20 (31.2%) and seven (10.9%) patients respectively. Resolution of reflux, defined as grade 0 to I, after one injection was seen in six (100%), 20 (64.5%), and 16 (80%) ureters from grade II to IV respectively. Only one patient with grade V reflux achieved complete resolution after a single injection. Of the 21 ureters which had residual reflux, three were lost from follow up and 18 (ten grade III, two grade IV and six grade V) received a second injection and eventually 12 ureters achieved resolution. Thus, the overall success rate was 67.2% after a single injection and 85.9% after two injections. No procedure-related complications was reported. CONCLUSION: Injections of Deflux is an effective treatment for VUR. A significant reduction in disease severity was seen in patients with grade II to IV disease after a single injection. Most patients with grade V disease needed more than one injection before achieving complete resolution. With this high success rate, we recommend the use of endoscopic Deflux injection as the first line treatment for children with vesicoureteric reflux disease. [Asian J Surg 2009;32(3): 163-6] © 2009 Elsevier. All rights reserved.
 
ISSN1015-9584
2013 Impact Factor: 0.758
2013 SCImago Journal Rankings: 0.361
 
DOIhttp://dx.doi.org/10.1016/S1015-9584(09)60388-2
 
ISI Accession Number IDWOS:000269556600006
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChung, PHY
 
dc.contributor.authorLan, LCL
 
dc.contributor.authorWong, KKY
 
dc.contributor.authorTarn, PKH
 
dc.date.accessioned2010-09-06T08:54:42Z
 
dc.date.available2010-09-06T08:54:42Z
 
dc.date.issued2009
 
dc.description.abstractBACKGROUND: Vesicoureteric reflux (VUR) is a common condition that may lead to end-staged renal failure. Treatment options include long term prophylactic antibiotics or surgical intervention. Recently, endoscopic treatment by a subureteral injection of Deflux has gained popularity. Our centre has introduced this treatment modality since 2002. METHODS: The medical records of 42 patients (15 male and 27 female) who received Deflux injections for treatment of VUR from 2002 to 2007 were reviewed. All the patients were followed up with voiding cystourethrograms at 3 months after the procedure. RESULTS: The median age at operation was 72.59 months (range, 8 to 216 months). Unilateral involvement was found in 20 patients while 22 patients had bilateral involvement. Of the 64 ureters, VUR were grade II to V in six (9.4%), 31 (48.4%), 20 (31.2%) and seven (10.9%) patients respectively. Resolution of reflux, defined as grade 0 to I, after one injection was seen in six (100%), 20 (64.5%), and 16 (80%) ureters from grade II to IV respectively. Only one patient with grade V reflux achieved complete resolution after a single injection. Of the 21 ureters which had residual reflux, three were lost from follow up and 18 (ten grade III, two grade IV and six grade V) received a second injection and eventually 12 ureters achieved resolution. Thus, the overall success rate was 67.2% after a single injection and 85.9% after two injections. No procedure-related complications was reported. CONCLUSION: Injections of Deflux is an effective treatment for VUR. A significant reduction in disease severity was seen in patients with grade II to IV disease after a single injection. Most patients with grade V disease needed more than one injection before achieving complete resolution. With this high success rate, we recommend the use of endoscopic Deflux injection as the first line treatment for children with vesicoureteric reflux disease. [Asian J Surg 2009;32(3): 163-6] © 2009 Elsevier. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAsian Journal Of Surgery, 2009, v. 32 n. 3, p. 163-166 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S1015-9584(09)60388-2
 
dc.identifier.doihttp://dx.doi.org/10.1016/S1015-9584(09)60388-2
 
dc.identifier.epage166
 
dc.identifier.hkuros160469
 
dc.identifier.isiWOS:000269556600006
 
dc.identifier.issn1015-9584
2013 Impact Factor: 0.758
2013 SCImago Journal Rankings: 0.361
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid19656756
 
dc.identifier.scopuseid_2-s2.0-70349283877
 
dc.identifier.spage163
 
dc.identifier.urihttp://hdl.handle.net/10722/84587
 
dc.identifier.volume32
 
dc.languageeng
 
dc.publisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofAsian Journal of Surgery
 
dc.relation.referencesReferences in Scopus
 
dc.subjectDeflux
 
dc.subjectUrology
 
dc.subjectVesicoureteric reflux
 
dc.titleDeflux injection for the treatment of vesicoureteric reflux in children-a single centre's experience
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong