Article: Deflux injection for the treatment of vesicoureteric reflux in children-a single centre's experience

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleDeflux injection for the treatment of vesicoureteric reflux in children-a single centre's experience
AuthorsChung, PHY1
Lan, LCL1
Wong, KKY1
Tarn, PKH1
KeywordsDeflux
Urology
Vesicoureteric reflux
Issue Date2009
PublisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
CitationAsian Journal Of Surgery, 2009, v. 32 n. 3, p. 163-166 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S1015-9584(09)60388-2
AbstractBACKGROUND: Vesicoureteric reflux (VUR) is a common condition that may lead to end-staged renal failure. Treatment options include long term prophylactic antibiotics or surgical intervention. Recently, endoscopic treatment by a subureteral injection of Deflux has gained popularity. Our centre has introduced this treatment modality since 2002. METHODS: The medical records of 42 patients (15 male and 27 female) who received Deflux injections for treatment of VUR from 2002 to 2007 were reviewed. All the patients were followed up with voiding cystourethrograms at 3 months after the procedure. RESULTS: The median age at operation was 72.59 months (range, 8 to 216 months). Unilateral involvement was found in 20 patients while 22 patients had bilateral involvement. Of the 64 ureters, VUR were grade II to V in six (9.4%), 31 (48.4%), 20 (31.2%) and seven (10.9%) patients respectively. Resolution of reflux, defined as grade 0 to I, after one injection was seen in six (100%), 20 (64.5%), and 16 (80%) ureters from grade II to IV respectively. Only one patient with grade V reflux achieved complete resolution after a single injection. Of the 21 ureters which had residual reflux, three were lost from follow up and 18 (ten grade III, two grade IV and six grade V) received a second injection and eventually 12 ureters achieved resolution. Thus, the overall success rate was 67.2% after a single injection and 85.9% after two injections. No procedure-related complications was reported. CONCLUSION: Injections of Deflux is an effective treatment for VUR. A significant reduction in disease severity was seen in patients with grade II to IV disease after a single injection. Most patients with grade V disease needed more than one injection before achieving complete resolution. With this high success rate, we recommend the use of endoscopic Deflux injection as the first line treatment for children with vesicoureteric reflux disease. [Asian J Surg 2009;32(3): 163-6] © 2009 Elsevier. All rights reserved.
ISSN1015-9584
2011 Impact Factor: 0.575
2011 SCImago Journal Rankings: 0.070
DOIhttp://dx.doi.org/10.1016/S1015-9584(09)60388-2
ISI Accession Number IDWOS:000269556600006
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChung, PHY
dc.contributor.authorLan, LCL
dc.contributor.authorWong, KKY
dc.contributor.authorTarn, PKH
dc.date.accessioned2010-09-06T08:54:42Z
dc.date.available2010-09-06T08:54:42Z
dc.date.issued2009
dc.description.abstractBACKGROUND: Vesicoureteric reflux (VUR) is a common condition that may lead to end-staged renal failure. Treatment options include long term prophylactic antibiotics or surgical intervention. Recently, endoscopic treatment by a subureteral injection of Deflux has gained popularity. Our centre has introduced this treatment modality since 2002. METHODS: The medical records of 42 patients (15 male and 27 female) who received Deflux injections for treatment of VUR from 2002 to 2007 were reviewed. All the patients were followed up with voiding cystourethrograms at 3 months after the procedure. RESULTS: The median age at operation was 72.59 months (range, 8 to 216 months). Unilateral involvement was found in 20 patients while 22 patients had bilateral involvement. Of the 64 ureters, VUR were grade II to V in six (9.4%), 31 (48.4%), 20 (31.2%) and seven (10.9%) patients respectively. Resolution of reflux, defined as grade 0 to I, after one injection was seen in six (100%), 20 (64.5%), and 16 (80%) ureters from grade II to IV respectively. Only one patient with grade V reflux achieved complete resolution after a single injection. Of the 21 ureters which had residual reflux, three were lost from follow up and 18 (ten grade III, two grade IV and six grade V) received a second injection and eventually 12 ureters achieved resolution. Thus, the overall success rate was 67.2% after a single injection and 85.9% after two injections. No procedure-related complications was reported. CONCLUSION: Injections of Deflux is an effective treatment for VUR. A significant reduction in disease severity was seen in patients with grade II to IV disease after a single injection. Most patients with grade V disease needed more than one injection before achieving complete resolution. With this high success rate, we recommend the use of endoscopic Deflux injection as the first line treatment for children with vesicoureteric reflux disease. [Asian J Surg 2009;32(3): 163-6] © 2009 Elsevier. All rights reserved.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationAsian Journal Of Surgery, 2009, v. 32 n. 3, p. 163-166 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S1015-9584(09)60388-2
dc.identifier.doihttp://dx.doi.org/10.1016/S1015-9584(09)60388-2
dc.identifier.epage166
dc.identifier.hkuros160469
dc.identifier.isiWOS:000269556600006
dc.identifier.issn1015-9584
2011 Impact Factor: 0.575
2011 SCImago Journal Rankings: 0.070
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid19656756
dc.identifier.scopuseid_2-s2.0-70349283877
dc.identifier.spage163
dc.identifier.urihttp://hdl.handle.net/10722/84587
dc.identifier.volume32
dc.languageeng
dc.publisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
dc.publisher.placeHong Kong
dc.relation.ispartofAsian Journal of Surgery
dc.relation.referencesReferences in Scopus
dc.subjectDeflux
dc.subjectUrology
dc.subjectVesicoureteric reflux
dc.titleDeflux injection for the treatment of vesicoureteric reflux in children-a single centre's experience
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong