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Article: Desmopressin does not decrease blood loss and transfusion requirements in patients undergoing hepatectomy

TitleDesmopressin does not decrease blood loss and transfusion requirements in patients undergoing hepatectomy
Authors
Issue Date2003
PublisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/medicine/anesthesiology/journal/12630
Citation
Canadian Journal Of Anesthesia, 2003, v. 50 n. 1, p. 14-20 How to Cite?
AbstractPurpose: To determine the effects of desmopressin on coagulation and blood loss in patients undergoing elective partial hepatectomy. Methods: A randomized, controlled and double-blind study on 59 patients who received either 0.3 μg·kg -1 of desmopressin or an equal volume of normal saline (control) infused intravenously over 20 min after induction of general anesthesia. Results: There was an increase in plasma levels of factors VIII and von Willebrand after the infusion of study drug in both groups (P < 0.001). The activated partial thromboplastin time was shortened in Group D whereas prothrombin time was prolonged in Group C; (P = 0.02). A large range of intraoperative blood loss (400-7128 mL) was observed, with no significant differences between groups. There were no changes in plasma electrolyte levels or osmolality. Transfusion requirements were similar in both groups. Conclusion: Desmopressin did not reduce intraoperative blood loss or transfusion requirements during hepatectomy despite raising clotting factor levels and improving tests of hemostasis.
Persistent Identifierhttp://hdl.handle.net/10722/84567
ISSN
2015 Impact Factor: 2.139
2015 SCImago Journal Rankings: 0.884
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, AYCen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorHui, TWCen_HK
dc.contributor.authorFung, SKYen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorMa, ESKen_HK
dc.date.accessioned2010-09-06T08:54:28Z-
dc.date.available2010-09-06T08:54:28Z-
dc.date.issued2003en_HK
dc.identifier.citationCanadian Journal Of Anesthesia, 2003, v. 50 n. 1, p. 14-20en_HK
dc.identifier.issn0832-610Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/84567-
dc.description.abstractPurpose: To determine the effects of desmopressin on coagulation and blood loss in patients undergoing elective partial hepatectomy. Methods: A randomized, controlled and double-blind study on 59 patients who received either 0.3 μg·kg -1 of desmopressin or an equal volume of normal saline (control) infused intravenously over 20 min after induction of general anesthesia. Results: There was an increase in plasma levels of factors VIII and von Willebrand after the infusion of study drug in both groups (P < 0.001). The activated partial thromboplastin time was shortened in Group D whereas prothrombin time was prolonged in Group C; (P = 0.02). A large range of intraoperative blood loss (400-7128 mL) was observed, with no significant differences between groups. There were no changes in plasma electrolyte levels or osmolality. Transfusion requirements were similar in both groups. Conclusion: Desmopressin did not reduce intraoperative blood loss or transfusion requirements during hepatectomy despite raising clotting factor levels and improving tests of hemostasis.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/medicine/anesthesiology/journal/12630en_HK
dc.relation.ispartofCanadian Journal of Anesthesiaen_HK
dc.subject.meshBlood Coagulation Testsen_HK
dc.subject.meshBlood Loss, Surgical - prevention & controlen_HK
dc.subject.meshBlood Transfusionen_HK
dc.subject.meshDeamino Arginine Vasopressin - therapeutic useen_HK
dc.subject.meshDouble-Blind Methoden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHemoglobins - drug effectsen_HK
dc.subject.meshHemostatics - therapeutic useen_HK
dc.subject.meshHepatectomyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Cirrhosis - blood - surgeryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOsmolar Concentrationen_HK
dc.subject.meshPlatelet Counten_HK
dc.subject.meshPotassium - blooden_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshSodium - blooden_HK
dc.titleDesmopressin does not decrease blood loss and transfusion requirements in patients undergoing hepatectomyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0832-610X&volume=50&spage=14&epage=20 &date=2003&atitle=Desmopressin+does+not+decrease+blood+loss+and+transfusion+requirements+in+patients+undergoing+hepatectomyen_HK
dc.identifier.emailIrwin, MG: mgirwin@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12514144-
dc.identifier.scopuseid_2-s2.0-0037285948en_HK
dc.identifier.hkuros79687en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037285948&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue1en_HK
dc.identifier.spage14en_HK
dc.identifier.epage20en_HK
dc.identifier.isiWOS:000180522500005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, AYC=7403147095en_HK
dc.identifier.scopusauthoridIrwin, MG=7202411076en_HK
dc.identifier.scopusauthoridHui, TWC=7005618934en_HK
dc.identifier.scopusauthoridFung, SKY=36985951600en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridMa, ESK=7202039934en_HK

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