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Article: Molecular adsorbent recirculating system treatment for patients with liver failure: The Hong Kong experience

TitleMolecular adsorbent recirculating system treatment for patients with liver failure: The Hong Kong experience
Authors
KeywordsAlbumin dialysis
Liver failure
Liver support therapy
Liver transplantation
MARS
Issue Date2006
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1
Citation
Liver International, 2006, v. 26 n. 6, p. 695-702 How to Cite?
AbstractBackground: The molecular adsorbent recirculating system (MARS) is an extracorporeal liver dialysis system that allows selective removal of bilirubin and other albumin-bound toxins. We reported here our experience with the use of this technique for management of liver failure at Queen Mary Hospital, Hong Kong. Methods: From December 2002 to 2004, a total of 74 MARS sessions were performed on 22 patients. The cause of liver failure included acute liver failure (n = 2), acute on chronic liver failure (n = 12), posthepatectomy liver failure (n = 4), and posttransplantation allograft failure (n = 4). Results: MARS treatment showed significant reduction in total bilirubin level, serum ammonia level and blood urea, and nitrogen (P<0.001 for all three parameters). Five patients (22.7%) were able to bridge to transplantation and one patient (4.5%) made a spontaneous recovery. The 30-day mortality rate was 72.7%. Conclusions: Our results indicated that MARS can effectively improve serum biochemistry and is suitable for temporarily supporting patients with liver failure where transplantation is not immediately available. There is, however, no clear evidence showing that MARS can increase survival, improve the chance of transplantation or assist liver regeneration. Future studies in the form of randomized-controlled trials are crucial to characterize the true potential of this treatment. © 2006 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/84505
ISSN
2015 Impact Factor: 4.47
2015 SCImago Journal Rankings: 1.677
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChiu, Aen_HK
dc.contributor.authorChan, LMYen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:53:44Z-
dc.date.available2010-09-06T08:53:44Z-
dc.date.issued2006en_HK
dc.identifier.citationLiver International, 2006, v. 26 n. 6, p. 695-702en_HK
dc.identifier.issn1478-3223en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84505-
dc.description.abstractBackground: The molecular adsorbent recirculating system (MARS) is an extracorporeal liver dialysis system that allows selective removal of bilirubin and other albumin-bound toxins. We reported here our experience with the use of this technique for management of liver failure at Queen Mary Hospital, Hong Kong. Methods: From December 2002 to 2004, a total of 74 MARS sessions were performed on 22 patients. The cause of liver failure included acute liver failure (n = 2), acute on chronic liver failure (n = 12), posthepatectomy liver failure (n = 4), and posttransplantation allograft failure (n = 4). Results: MARS treatment showed significant reduction in total bilirubin level, serum ammonia level and blood urea, and nitrogen (P<0.001 for all three parameters). Five patients (22.7%) were able to bridge to transplantation and one patient (4.5%) made a spontaneous recovery. The 30-day mortality rate was 72.7%. Conclusions: Our results indicated that MARS can effectively improve serum biochemistry and is suitable for temporarily supporting patients with liver failure where transplantation is not immediately available. There is, however, no clear evidence showing that MARS can increase survival, improve the chance of transplantation or assist liver regeneration. Future studies in the form of randomized-controlled trials are crucial to characterize the true potential of this treatment. © 2006 Blackwell Munksgaard.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1en_HK
dc.relation.ispartofLiver Internationalen_HK
dc.subjectAlbumin dialysisen_HK
dc.subjectLiver failureen_HK
dc.subjectLiver support therapyen_HK
dc.subjectLiver transplantationen_HK
dc.subjectMARSen_HK
dc.titleMolecular adsorbent recirculating system treatment for patients with liver failure: The Hong Kong experienceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1478-3223&volume=26&issue=6&spage=695&epage=702&date=2006&atitle=Molecular+adsorbent+recirculating+system+treatment+for+patients+with+liver+failure:+the+Hong+Kong+experienceen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1478-3231.2006.01293.xen_HK
dc.identifier.pmid16842326-
dc.identifier.scopuseid_2-s2.0-33745590667en_HK
dc.identifier.hkuros117705en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745590667&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue6en_HK
dc.identifier.spage695en_HK
dc.identifier.epage702en_HK
dc.identifier.isiWOS:000238621100010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChiu, A=35721752900en_HK
dc.identifier.scopusauthoridChan, LMY=49762799200en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.citeulike738914-

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