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Conference Paper: Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy

TitleAnastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy
Authors
KeywordsAnastomotic leakage
Cancer-specific survival
Colorectal cancer
Curative colorectal resection
Malignancy
Issue Date2007
PublisherSpringer New York LLC.
Citation
The 47th Annual Meeting of the Society-for-Surgery-of the Alimentary-Tract, Los Angeles, CA, 20-24 May, 2006. In Journal Of Gastrointestinal Surgery, 2007, v. 11 n. 1, p. 8-15 How to Cite?
AbstractThe impact of anastomotic leakage on long-term outcomes after curative surgery for colorectal cancer has not been well documented. This study aimed to investigate the effect of anastomotic leakage on survival and tumor recurrence in patients who underwent curative resection for colorectal cancer. Prospectively collected data of the 1,580 patients (904 men) of a median age of 70 years (range: 24-94), who underwent potentially curative resection for colorectal cancer between 1996 and 2004, were reviewed. Cancer-specific survival and disease recurrence were analyzed using Kaplan Meier method, and variables were compared with log rank test. Cox regression model was used in multivariate analysis. The cancer was situated in the colon and the rectum in 933 and 647 patients, respectively. Anastomotic leakage occurred in 60 patients (clinical leakage: n∈=∈48; radiological leak: n∈=∈12). The leakage rate was significantly higher in patients with surgery for rectal cancer (6.3 vs 2.0%, p∈<∈0.001). The 5-year cancer-specific survivals were 56.9% in those with leakage and 75.9% in those without leakage (p∈=∈0.012). The 5-year systemic recurrence rates were 48.4 and 22.6% in patients with and without anastomotic leak, respectively (p∈=∈0.001), whereas the 5-year local recurrence rates were 12.9 and 5.7%, respectively (p∈=∈0.009). Anastomotic leakage remained an independent factor associated with a worse cancer-specific survival (p∈=∈0.043, hazard ratio: 1.63, 95% CI: 1.02-2.60) and a higher systemic recurrence rate (hazard ratio: 1.94, 95% CI: 1.23-3.06, p∈=∈0.004) on multivariate analysis. In rectal cancer, anastomotic leakage was an independent factor for a higher local recurrence rate (hazard ratio: 2.55, 95% CI: 1.07-6.06, p∈=∈0.034). In conclusion, anastomotic leakage is associated with a poor survival and a higher tumor recurrence rate after curative resection of colorectal cancer. Efforts should be undertaken to avoid this complication to improve the long-term outcome. © The Society for Surgery of the Alimentary Tract 2007.
Persistent Identifierhttp://hdl.handle.net/10722/84488
ISSN
2015 Impact Factor: 2.807
2015 SCImago Journal Rankings: 1.640
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLaw, WLen_HK
dc.contributor.authorChoi, HKen_HK
dc.contributor.authorLee, YMen_HK
dc.contributor.authorHo, JWCen_HK
dc.contributor.authorSeto, CLen_HK
dc.date.accessioned2010-09-06T08:53:33Z-
dc.date.available2010-09-06T08:53:33Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 47th Annual Meeting of the Society-for-Surgery-of the Alimentary-Tract, Los Angeles, CA, 20-24 May, 2006. In Journal Of Gastrointestinal Surgery, 2007, v. 11 n. 1, p. 8-15en_HK
dc.identifier.issn1091-255Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/84488-
dc.description.abstractThe impact of anastomotic leakage on long-term outcomes after curative surgery for colorectal cancer has not been well documented. This study aimed to investigate the effect of anastomotic leakage on survival and tumor recurrence in patients who underwent curative resection for colorectal cancer. Prospectively collected data of the 1,580 patients (904 men) of a median age of 70 years (range: 24-94), who underwent potentially curative resection for colorectal cancer between 1996 and 2004, were reviewed. Cancer-specific survival and disease recurrence were analyzed using Kaplan Meier method, and variables were compared with log rank test. Cox regression model was used in multivariate analysis. The cancer was situated in the colon and the rectum in 933 and 647 patients, respectively. Anastomotic leakage occurred in 60 patients (clinical leakage: n∈=∈48; radiological leak: n∈=∈12). The leakage rate was significantly higher in patients with surgery for rectal cancer (6.3 vs 2.0%, p∈<∈0.001). The 5-year cancer-specific survivals were 56.9% in those with leakage and 75.9% in those without leakage (p∈=∈0.012). The 5-year systemic recurrence rates were 48.4 and 22.6% in patients with and without anastomotic leak, respectively (p∈=∈0.001), whereas the 5-year local recurrence rates were 12.9 and 5.7%, respectively (p∈=∈0.009). Anastomotic leakage remained an independent factor associated with a worse cancer-specific survival (p∈=∈0.043, hazard ratio: 1.63, 95% CI: 1.02-2.60) and a higher systemic recurrence rate (hazard ratio: 1.94, 95% CI: 1.23-3.06, p∈=∈0.004) on multivariate analysis. In rectal cancer, anastomotic leakage was an independent factor for a higher local recurrence rate (hazard ratio: 2.55, 95% CI: 1.07-6.06, p∈=∈0.034). In conclusion, anastomotic leakage is associated with a poor survival and a higher tumor recurrence rate after curative resection of colorectal cancer. Efforts should be undertaken to avoid this complication to improve the long-term outcome. © The Society for Surgery of the Alimentary Tract 2007.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC.en_HK
dc.relation.ispartofJournal of Gastrointestinal Surgeryen_HK
dc.subjectAnastomotic leakageen_HK
dc.subjectCancer-specific survivalen_HK
dc.subjectColorectal canceren_HK
dc.subjectCurative colorectal resectionen_HK
dc.subjectMalignancyen_HK
dc.titleAnastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancyen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1091-255X&volume=11&spage=8&epage=15&date=2007&atitle=Anastomotic+leakage+is+associated+with+poor+long-term+outcome+in+patients+after+curative+colorectal+resection+for+malignancyen_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11605-006-0049-zen_HK
dc.identifier.pmid17390180-
dc.identifier.scopuseid_2-s2.0-34250183826en_HK
dc.identifier.hkuros126184en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250183826&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1en_HK
dc.identifier.spage8en_HK
dc.identifier.epage15en_HK
dc.identifier.isiWOS:000244521500003-
dc.publisher.placeUnited Statesen_HK
dc.description.otherThe 47th Annual Meeting of the Society-for-Surgery-of the Alimentary-Tract, Los Angeles, CA, 20-24 May, 2006. In Journal Of Gastrointestinal Surgery, 2007, v. 11 n. 1, p. 8-15-
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK
dc.identifier.scopusauthoridChoi, HK=7404339913en_HK
dc.identifier.scopusauthoridLee, YM=8521465600en_HK
dc.identifier.scopusauthoridHo, JWC=7402649983en_HK
dc.identifier.scopusauthoridSeto, CL=7004637406en_HK

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