File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Complications of craniofacial resection for malignant tumors of the skull base: Report of an international collaborative study

TitleComplications of craniofacial resection for malignant tumors of the skull base: Report of an international collaborative study
Authors
KeywordsPostoperative complications
Skull base neoplasms/surgery
Issue Date2005
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 2005, v. 27 n. 6, p. 445-451 How to Cite?
AbstractBackground. Advances in imaging, surgical technique, and perioperative care have made craniofacial resection (CFR) an effective and safe option for treating malignant tumors involving the skull base. The procedure does, however, have complications. Because of the relative rarity of these tumors, most existing data on postoperative complications come from individual reports of relatively small series of patients. This international collaborative report examines a large cohort of patients accumulated from multiple institutions with the aim of identifying patient-related and tumor-related predictors of postoperative morbidity and mortality and set a benchmark for future studies. Methods. One thousand one hundred ninety-three patients from 17 institutions were analyzed for postoperative mortality and complications. Postoperative complications were classified into systemic, wound, central nervous system (CNS), and orbit. Statistical analyses were carried out in relation to patient characteristics, extent of disease, prior radiation treatment, and type of reconstruction to determine factors that predicted mortality or complications. Results. Postoperative mortality occurred in 56 patients (4.7%). The presence of medical comorbidity was the only independent predictor of mortality. Postoperative complications occurred in 433 patients (36.3%). Wound complications occurred in 237 (19.8%), CNS-related complications in 193 (16.2%), orbital complications in 20 (1.7%), and systemic complications in 57 (4.8%) patients. Medical comorbidity, prior radiation therapy, and the extent of intracranial tumour involvement were independent predictors of postoperative complications. Conclusions. CFR is a safe surgical treatment for malignant tumors of the skull base, with an overall mortality of 4.7% and complication rate of 36.3%. The impact of medical comorbidity and intracranial tumor extent should be carefully considered when planning therapy for patients whose tumors are amenable to CFR. © 2005 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/84459
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGanly, Ien_HK
dc.contributor.authorPatel, SGen_HK
dc.contributor.authorSingh, Ben_HK
dc.contributor.authorKraus, DHen_HK
dc.contributor.authorBridger, PGen_HK
dc.contributor.authorCantu, Gen_HK
dc.contributor.authorCheesman, Aen_HK
dc.contributor.authorDe Sa, Gen_HK
dc.contributor.authorDonald, Pen_HK
dc.contributor.authorFliss, Den_HK
dc.contributor.authorGullane, Pen_HK
dc.contributor.authorJanecka, Ien_HK
dc.contributor.authorKamata, SEen_HK
dc.contributor.authorKowalski, LPen_HK
dc.contributor.authorLevine, Pen_HK
dc.contributor.authorMedina, LRen_HK
dc.contributor.authorPradhan, Sen_HK
dc.contributor.authorSchramm, Ven_HK
dc.contributor.authorSnyderman, Cen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorShah, JPen_HK
dc.date.accessioned2010-09-06T08:53:13Z-
dc.date.available2010-09-06T08:53:13Z-
dc.date.issued2005en_HK
dc.identifier.citationHead And Neck, 2005, v. 27 n. 6, p. 445-451en_HK
dc.identifier.issn1043-3074en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84459-
dc.description.abstractBackground. Advances in imaging, surgical technique, and perioperative care have made craniofacial resection (CFR) an effective and safe option for treating malignant tumors involving the skull base. The procedure does, however, have complications. Because of the relative rarity of these tumors, most existing data on postoperative complications come from individual reports of relatively small series of patients. This international collaborative report examines a large cohort of patients accumulated from multiple institutions with the aim of identifying patient-related and tumor-related predictors of postoperative morbidity and mortality and set a benchmark for future studies. Methods. One thousand one hundred ninety-three patients from 17 institutions were analyzed for postoperative mortality and complications. Postoperative complications were classified into systemic, wound, central nervous system (CNS), and orbit. Statistical analyses were carried out in relation to patient characteristics, extent of disease, prior radiation treatment, and type of reconstruction to determine factors that predicted mortality or complications. Results. Postoperative mortality occurred in 56 patients (4.7%). The presence of medical comorbidity was the only independent predictor of mortality. Postoperative complications occurred in 433 patients (36.3%). Wound complications occurred in 237 (19.8%), CNS-related complications in 193 (16.2%), orbital complications in 20 (1.7%), and systemic complications in 57 (4.8%) patients. Medical comorbidity, prior radiation therapy, and the extent of intracranial tumour involvement were independent predictors of postoperative complications. Conclusions. CFR is a safe surgical treatment for malignant tumors of the skull base, with an overall mortality of 4.7% and complication rate of 36.3%. The impact of medical comorbidity and intracranial tumor extent should be carefully considered when planning therapy for patients whose tumors are amenable to CFR. © 2005 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.subjectPostoperative complicationsen_HK
dc.subjectSkull base neoplasms/surgeryen_HK
dc.titleComplications of craniofacial resection for malignant tumors of the skull base: Report of an international collaborative studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-8748&volume=27&spage=445&epage=451&date=2005&atitle=Complications+of+craniofacial+resection+for+malignant+tumors+of+the+skull+base:+report+of+an+International+Collaborative+Studyen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hed.20166en_HK
dc.identifier.pmid15825205-
dc.identifier.scopuseid_2-s2.0-20044377428en_HK
dc.identifier.hkuros103727en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20044377428&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue6en_HK
dc.identifier.spage445en_HK
dc.identifier.epage451en_HK
dc.identifier.isiWOS:000229461600001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGanly, I=6701500102en_HK
dc.identifier.scopusauthoridPatel, SG=7403903141en_HK
dc.identifier.scopusauthoridSingh, B=7405639360en_HK
dc.identifier.scopusauthoridKraus, DH=25947461900en_HK
dc.identifier.scopusauthoridBridger, PG=6603845621en_HK
dc.identifier.scopusauthoridCantu, G=7003498793en_HK
dc.identifier.scopusauthoridCheesman, A=7003676128en_HK
dc.identifier.scopusauthoridDe Sa, G=8561754500en_HK
dc.identifier.scopusauthoridDonald, P=7103189603en_HK
dc.identifier.scopusauthoridFliss, D=7005455625en_HK
dc.identifier.scopusauthoridGullane, P=7005484642en_HK
dc.identifier.scopusauthoridJanecka, I=7005569375en_HK
dc.identifier.scopusauthoridKamata, SE=35478208000en_HK
dc.identifier.scopusauthoridKowalski, LP=7102126040en_HK
dc.identifier.scopusauthoridLevine, P=35386674700en_HK
dc.identifier.scopusauthoridMedina, LR=8581762500en_HK
dc.identifier.scopusauthoridPradhan, S=7202877432en_HK
dc.identifier.scopusauthoridSchramm, V=35511790400en_HK
dc.identifier.scopusauthoridSnyderman, C=7005989580en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridShah, JP=7403266008en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats