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Article: Immunization with Epstein-Barr Virus (EBV) peptide-pulsed dendritic cells induces functional CD8+ T-cell immunity and may lead to tumor regression in patients with EBV-positive nasopharyngeal carcinoma

TitleImmunization with Epstein-Barr Virus (EBV) peptide-pulsed dendritic cells induces functional CD8+ T-cell immunity and may lead to tumor regression in patients with EBV-positive nasopharyngeal carcinoma
Authors
Issue Date2002
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2002, v. 62 n. 23, p. 6952-6958 How to Cite?
AbstractNasopharyngeal Carcinoma (Npc), A Common Neoplasm In Southeast Asia, Is Ebv-Positive And Expresses A Limited Number Of Antigens, Including Latent Membrane Protein 2. In This Study, Autologous Monocyte-Derived Dendritic Cells Were Cultured From Patients With Advanced Npc, Matured With Cytokine, Pulsed With Hla-A1101-, A2402-, Or B40011-Restricted Epitope Peptides From Ebv Latent Membrane Protein 2 And Injected Into Inguinal Lymph Nodes. Sixteen Patients With Local Recurrence Or Distant Metastasis After Conventional Therapies Received Four Injections At Weekly Intervals. Epitope-Specific Cd8+ T-Cell Responses Were Elicited Or Boosted In 9 Patients Receiving Hla-A1101- Or A2402-Restricted Peptides, With Stronger Responses Seen To The A1101 Peptide. Furthermore, Epitope-Specific Cytotoxicity Was Detectable In Peripheral Blood T Cells Harvested At 3-Months After Vaccination From A1101-Responsive Patients, And In 2 Patients, This Coincided With Partial Tumor Reduction. Approaches Leading To Stronger And More Sustained Ebv-Specific T-Cell Responses, Therefore, May Have Therapeutic Potential In The Context Of Npc.
Persistent Identifierhttp://hdl.handle.net/10722/84449
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, CLen_HK
dc.contributor.authorLo, WFen_HK
dc.contributor.authorLee, THen_HK
dc.contributor.authorRen, Yen_HK
dc.contributor.authorHwang, SLen_HK
dc.contributor.authorCheng, YFen_HK
dc.contributor.authorChen, CLen_HK
dc.contributor.authorChang, YSen_HK
dc.contributor.authorLee, SPen_HK
dc.contributor.authorRickinson, ABen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:53:05Z-
dc.date.available2010-09-06T08:53:05Z-
dc.date.issued2002en_HK
dc.identifier.citationCancer Research, 2002, v. 62 n. 23, p. 6952-6958en_US
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84449-
dc.description.abstractNasopharyngeal Carcinoma (Npc), A Common Neoplasm In Southeast Asia, Is Ebv-Positive And Expresses A Limited Number Of Antigens, Including Latent Membrane Protein 2. In This Study, Autologous Monocyte-Derived Dendritic Cells Were Cultured From Patients With Advanced Npc, Matured With Cytokine, Pulsed With Hla-A1101-, A2402-, Or B40011-Restricted Epitope Peptides From Ebv Latent Membrane Protein 2 And Injected Into Inguinal Lymph Nodes. Sixteen Patients With Local Recurrence Or Distant Metastasis After Conventional Therapies Received Four Injections At Weekly Intervals. Epitope-Specific Cd8+ T-Cell Responses Were Elicited Or Boosted In 9 Patients Receiving Hla-A1101- Or A2402-Restricted Peptides, With Stronger Responses Seen To The A1101 Peptide. Furthermore, Epitope-Specific Cytotoxicity Was Detectable In Peripheral Blood T Cells Harvested At 3-Months After Vaccination From A1101-Responsive Patients, And In 2 Patients, This Coincided With Partial Tumor Reduction. Approaches Leading To Stronger And More Sustained Ebv-Specific T-Cell Responses, Therefore, May Have Therapeutic Potential In The Context Of Npc.en_US
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.titleImmunization with Epstein-Barr Virus (EBV) peptide-pulsed dendritic cells induces functional CD8+ T-cell immunity and may lead to tumor regression in patients with EBV-positive nasopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-5472&volume=62&spage=6952&epage=6958&date=2002&atitle=Immunization+with+Epstein-Barr+Virus+(EBV)+peptide-pulsed+dendritic+cells+induces+functional+CD8++T-cell+immunity+and+may+lead+to+tumor+regression+in+patients+with+EBV-positive++nasopharyngeal+carcinomaen_HK
dc.identifier.emailLin, CL: clin@hkucc.hku.hken_HK
dc.identifier.emailRen, Y: yren@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12460912-
dc.identifier.scopuseid_2-s2.0-0036896225en_US
dc.identifier.hkuros78924en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036896225&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume62en_US
dc.identifier.issue23en_US
dc.identifier.spage6952en_US
dc.identifier.epage6958en_US
dc.identifier.isiWOS:000179641000027-

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