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Article: Current issues and treatment of fulminant hepatic failure including transplantation in Hong Kong and the Far East

TitleCurrent issues and treatment of fulminant hepatic failure including transplantation in Hong Kong and the Far East
Authors
KeywordsFar East
Fulminant hepatic failure
Hepatitis B infection
Liver transplantation
Issue Date2003
PublisherThieme Medical Publishers. The Journal's web site is located at http://www.thieme.de/sld/index.html
Citation
Seminars In Liver Disease, 2003, v. 23 n. 3, p. 239-250 How to Cite?
AbstractIn the Far East, fulminant hepatic failure is mainly due to viral hepatitis. In areas where hepatitis B infection is endemic, exacerbation of chronic hepatitis B infection, either spontaneously or on withdrawal of immunosuppressive therapy, is the major cause of fulminant hepatic failure. For hepatitis B surface antigen (HBsAg)-positive patients treated with intense immunosuppressive or cytotoxic therapy, preemptive use of lamivudine has drastically reduced the incidence of hepatitis due to hepatitis B exacerbation. Recently, the application of orthotopic liver transplantation, in particular living donor liver transplantation, has markedly improved the survival of patients with fulminant hepatic failure. In Hong Kong, the phenomenon of adoptive transfer of immunity to hepatitis B virus in liver transplantation has recently been reported. The mechanisms by which transfer of immunity occurs and its potential relationship with grafts from living related donors should be further explored.
Persistent Identifierhttp://hdl.handle.net/10722/84416
ISSN
2015 Impact Factor: 5.667
2015 SCImago Journal Rankings: 2.693
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorLau, GKKen_HK
dc.date.accessioned2010-09-06T08:52:43Z-
dc.date.available2010-09-06T08:52:43Z-
dc.date.issued2003en_HK
dc.identifier.citationSeminars In Liver Disease, 2003, v. 23 n. 3, p. 239-250en_HK
dc.identifier.issn0272-8087en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84416-
dc.description.abstractIn the Far East, fulminant hepatic failure is mainly due to viral hepatitis. In areas where hepatitis B infection is endemic, exacerbation of chronic hepatitis B infection, either spontaneously or on withdrawal of immunosuppressive therapy, is the major cause of fulminant hepatic failure. For hepatitis B surface antigen (HBsAg)-positive patients treated with intense immunosuppressive or cytotoxic therapy, preemptive use of lamivudine has drastically reduced the incidence of hepatitis due to hepatitis B exacerbation. Recently, the application of orthotopic liver transplantation, in particular living donor liver transplantation, has markedly improved the survival of patients with fulminant hepatic failure. In Hong Kong, the phenomenon of adoptive transfer of immunity to hepatitis B virus in liver transplantation has recently been reported. The mechanisms by which transfer of immunity occurs and its potential relationship with grafts from living related donors should be further explored.en_HK
dc.languageengen_HK
dc.publisherThieme Medical Publishers. The Journal's web site is located at http://www.thieme.de/sld/index.htmlen_HK
dc.relation.ispartofSeminars in Liver Diseaseen_HK
dc.subjectFar Easten_HK
dc.subjectFulminant hepatic failureen_HK
dc.subjectHepatitis B infectionen_HK
dc.subjectLiver transplantationen_HK
dc.titleCurrent issues and treatment of fulminant hepatic failure including transplantation in Hong Kong and the Far Easten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0272-8087&volume=23&issue=3&spage=239&epage=250&date=2003&atitle=Current+issues+and+treatment+of+fulminant+hepatic+failure+including+transplantation+in+Hong+Kong+and+the+Far+Easten_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1055/s-2003-42642en_HK
dc.identifier.pmid14523677-
dc.identifier.scopuseid_2-s2.0-0042820260en_HK
dc.identifier.hkuros87760en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0042820260&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue3en_HK
dc.identifier.spage239en_HK
dc.identifier.epage250en_HK
dc.identifier.isiWOS:000185116300006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK

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