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Article: The clinicopathological significance of bcl-2 expression in the surgical treatment of laryngeal carcinoma

TitleThe clinicopathological significance of bcl-2 expression in the surgical treatment of laryngeal carcinoma
Authors
KeywordsApoptosis
Bcl-2
Head and neck
Laryngeal carcinoma
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/COA
Citation
Clinical Otolaryngology And Allied Sciences, 2001, v. 26 n. 2, p. 129-133 How to Cite?
AbstractBcl-2 expression was studied by immunohistochemistry on laryngectomy specimens from 176 patients. Of the 176 tumours, 11% had positive bcl-2 staining. Bcl-2 expression was significantly correlated with tumour grade: 5% of well-differentiated tumours, 12% of moderately-differentiated tumours and 23% of poorly-differentiated tumours had positive expression of bcl-2. Nodal metastases were also found to be significantly related to bcl-2 expression: 36% of nodal metastases for negative bcl-2 expression compared with 70% for positive expression. The risk of nodal metastases increased significantly with the presence of bcl-2 expression, moderate or poor differentiation and supraglottic involvement. The risk of nodal metastases increased significantly with the presence of increasing numbers of risk factors: 11% without risk factor, 21% with one risk factor, 49% with two risk factors and 77% with three risk factors. Bcl-2 expression in laryngeal carcinoma is significantly correlated with tumour grade and nodal metastases. It has added prognostic value for nodal metastases together with tumour grade and site of tumour involvement.
Persistent Identifierhttp://hdl.handle.net/10722/84410
ISSN
2005 Impact Factor: 0.983
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, APWen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorChoy, JTHen_HK
dc.contributor.authorHo, WKen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-09-06T08:52:39Z-
dc.date.available2010-09-06T08:52:39Z-
dc.date.issued2001en_HK
dc.identifier.citationClinical Otolaryngology And Allied Sciences, 2001, v. 26 n. 2, p. 129-133en_HK
dc.identifier.issn0307-7772en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84410-
dc.description.abstractBcl-2 expression was studied by immunohistochemistry on laryngectomy specimens from 176 patients. Of the 176 tumours, 11% had positive bcl-2 staining. Bcl-2 expression was significantly correlated with tumour grade: 5% of well-differentiated tumours, 12% of moderately-differentiated tumours and 23% of poorly-differentiated tumours had positive expression of bcl-2. Nodal metastases were also found to be significantly related to bcl-2 expression: 36% of nodal metastases for negative bcl-2 expression compared with 70% for positive expression. The risk of nodal metastases increased significantly with the presence of bcl-2 expression, moderate or poor differentiation and supraglottic involvement. The risk of nodal metastases increased significantly with the presence of increasing numbers of risk factors: 11% without risk factor, 21% with one risk factor, 49% with two risk factors and 77% with three risk factors. Bcl-2 expression in laryngeal carcinoma is significantly correlated with tumour grade and nodal metastases. It has added prognostic value for nodal metastases together with tumour grade and site of tumour involvement.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/COAen_HK
dc.relation.ispartofClinical Otolaryngology and Allied Sciencesen_HK
dc.rightsClinical Otolaryngology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectApoptosisen_HK
dc.subjectBcl-2en_HK
dc.subjectHead and necken_HK
dc.subjectLaryngeal carcinomaen_HK
dc.titleThe clinicopathological significance of bcl-2 expression in the surgical treatment of laryngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1749-4478&volume=26&issue=2&spage=129&epage=133&date=2001&atitle=The+clinicopathological+significance+of+bcl-2+expression+in+the+surgical+treatment+of+laryngeal+carcinomaen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2273.2001.00441.xen_HK
dc.identifier.pmid11309054-
dc.identifier.scopuseid_2-s2.0-0035045658en_HK
dc.identifier.hkuros72097en_HK
dc.identifier.hkuros60570-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035045658&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue2en_HK
dc.identifier.spage129en_HK
dc.identifier.epage133en_HK
dc.identifier.isiWOS:000168379700011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, APW=7006290111en_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridChoy, JTH=7101643665en_HK
dc.identifier.scopusauthoridHo, WK=7402968844en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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