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Article: Comparison of systemic responses of radiofrequency ablation, cryotherapy, and surgical resection in a porcine liver model

TitleComparison of systemic responses of radiofrequency ablation, cryotherapy, and surgical resection in a porcine liver model
Authors
KeywordsAblation
Cryotherapy
Radiofrequency
Responses
Systemic
Issue Date2004
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals Of Surgical Oncology, 2004, v. 11 n. 7, p. 650-657 How to Cite?
AbstractBackground: The degree of systemic response after hepatic radiofrequency ablation (RFA) has not been well investigated. Methods: An in vivo study was conducted on 23 domestic swine. Different hepatic procedures (RFA, cryotherapy, hepatic pedicle ligation, and hepatectomy) were performed on the medial lobe of the liver (30% of the liver volume). Systemic responses in terms of systemic inflammatory marker changes and end-organ functions were determined. Results: During the early postoperative period, the systemic inflammatory marker concentrations (tumor necrosis factor-α and interleukin-1β) in the RFA group were significantly lower than in the cryotherapy group but significantly higher than in the control group. The corresponding concentrations in the hepatectomy group remained similar to those in the control group. The pattern of changes of serum inflammatory marker concentrations in the pedicle ligation group followed the pattern in the RFA group. The serum intracellular content concentrations (lactate dehydrogenase and urate) of the cryotherapy group peaked at 6 hours after operation, which was significantly later than in the other groups. Liver function, renal function, and coagulation profiles remained normal in the RFA group. However, the renal function deteriorated in the cryotherapy group on day 1. Both platelet count and activated clotting time showed significant derangement in the cryotherapy group compared with the control group. There was more severe interstitial pneumonitic change of the porcine lung after cryotherapy than after RFA. Conclusions: The systemic responses of RFA were significantly less severe than those of cryotherapy in this porcine model. However, the increase in serum inflammatory markers and pneumonitis after RFA was substantial when compared with hepatectomy. © 2004 The Society of Surgical Oncology, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/84406
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, KKen_HK
dc.contributor.authorLam, CMen_HK
dc.contributor.authorPoon, RTen_HK
dc.contributor.authorShek, TWen_HK
dc.contributor.authorTo, JYen_HK
dc.contributor.authorWo, YHen_HK
dc.contributor.authorHo, DWen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:52:34Z-
dc.date.available2010-09-06T08:52:34Z-
dc.date.issued2004en_HK
dc.identifier.citationAnnals Of Surgical Oncology, 2004, v. 11 n. 7, p. 650-657en_HK
dc.identifier.issn1068-9265en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84406-
dc.description.abstractBackground: The degree of systemic response after hepatic radiofrequency ablation (RFA) has not been well investigated. Methods: An in vivo study was conducted on 23 domestic swine. Different hepatic procedures (RFA, cryotherapy, hepatic pedicle ligation, and hepatectomy) were performed on the medial lobe of the liver (30% of the liver volume). Systemic responses in terms of systemic inflammatory marker changes and end-organ functions were determined. Results: During the early postoperative period, the systemic inflammatory marker concentrations (tumor necrosis factor-α and interleukin-1β) in the RFA group were significantly lower than in the cryotherapy group but significantly higher than in the control group. The corresponding concentrations in the hepatectomy group remained similar to those in the control group. The pattern of changes of serum inflammatory marker concentrations in the pedicle ligation group followed the pattern in the RFA group. The serum intracellular content concentrations (lactate dehydrogenase and urate) of the cryotherapy group peaked at 6 hours after operation, which was significantly later than in the other groups. Liver function, renal function, and coagulation profiles remained normal in the RFA group. However, the renal function deteriorated in the cryotherapy group on day 1. Both platelet count and activated clotting time showed significant derangement in the cryotherapy group compared with the control group. There was more severe interstitial pneumonitic change of the porcine lung after cryotherapy than after RFA. Conclusions: The systemic responses of RFA were significantly less severe than those of cryotherapy in this porcine model. However, the increase in serum inflammatory markers and pneumonitis after RFA was substantial when compared with hepatectomy. © 2004 The Society of Surgical Oncology, Inc.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.orgen_HK
dc.relation.ispartofAnnals of Surgical Oncologyen_HK
dc.subjectAblationen_HK
dc.subjectCryotherapyen_HK
dc.subjectRadiofrequencyen_HK
dc.subjectResponsesen_HK
dc.subjectSystemicen_HK
dc.titleComparison of systemic responses of radiofrequency ablation, cryotherapy, and surgical resection in a porcine liver modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1068-9265&volume=11&issue=7&spage=650&epage=657&date=2004&atitle=Comparison+of+systemic+responses+of+radiofrequency+ablation,+cryotherapy,+and+surgical+resection+in+a+porcine+liver+modelen_HK
dc.identifier.emailPoon, RT: poontp@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1245/ASO.2004.10.027en_HK
dc.identifier.pmid15231521en_HK
dc.identifier.scopuseid_2-s2.0-14344258798en_HK
dc.identifier.hkuros96807en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14344258798&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue7en_HK
dc.identifier.spage650en_HK
dc.identifier.epage657en_HK
dc.identifier.isiWOS:000222427000005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, KK=7403179075en_HK
dc.identifier.scopusauthoridLam, CM=7402989820en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK
dc.identifier.scopusauthoridShek, TW=7005479861en_HK
dc.identifier.scopusauthoridTo, JY=6603618643en_HK
dc.identifier.scopusauthoridWo, YH=8207975200en_HK
dc.identifier.scopusauthoridHo, DW=7402971906en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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