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Article: Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

TitleSignificance of CD90+ Cancer Stem Cells in Human Liver Cancer
Authors
KeywordsCELLCYCLE
STEMCELL
Issue Date2008
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/ccell
Citation
Cancer Cell, 2008, v. 13 n. 2, p. 153-166 How to Cite?
AbstractThis study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90+ cells, but not the CD90- cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45-CD90+ population, which could generate tumor nodules in immunodeficient mice. The CD90+CD44+ cells demonstrated a more aggressive phenotype than the CD90+CD44- counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90+ cells. Differential gene expression profiles were identified in the CD45-CD90+ and CD45-CD90- cells isolated from tissue and blood samples from liver cancer patients and controls. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84403
ISSN
2015 Impact Factor: 23.214
2015 SCImago Journal Rankings: 13.922
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, ZFen_HK
dc.contributor.authorHo, DWen_HK
dc.contributor.authorNg, MNen_HK
dc.contributor.authorLau, CKen_HK
dc.contributor.authorYu, WCen_HK
dc.contributor.authorNgai, Pen_HK
dc.contributor.authorChu, PWKen_HK
dc.contributor.authorLam, CTen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:52:32Z-
dc.date.available2010-09-06T08:52:32Z-
dc.date.issued2008en_HK
dc.identifier.citationCancer Cell, 2008, v. 13 n. 2, p. 153-166en_HK
dc.identifier.issn1535-6108en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84403-
dc.description.abstractThis study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90+ cells, but not the CD90- cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45-CD90+ population, which could generate tumor nodules in immunodeficient mice. The CD90+CD44+ cells demonstrated a more aggressive phenotype than the CD90+CD44- counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90+ cells. Differential gene expression profiles were identified in the CD45-CD90+ and CD45-CD90- cells isolated from tissue and blood samples from liver cancer patients and controls. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/ccellen_HK
dc.relation.ispartofCancer Cellen_HK
dc.subjectCELLCYCLEen_HK
dc.subjectSTEMCELLen_HK
dc.titleSignificance of CD90+ Cancer Stem Cells in Human Liver Canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1535-6108&volume=13&issue=2&spage=153&epage=166&date=2008&atitle=Significance+of+CD90++cancer+stem+cells+in+human+liver+canceren_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.ccr.2008.01.013en_HK
dc.identifier.pmid18242515-
dc.identifier.scopuseid_2-s2.0-38549139140en_HK
dc.identifier.hkuros140749en_HK
dc.identifier.hkuros166238-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38549139140&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue2en_HK
dc.identifier.spage153en_HK
dc.identifier.epage166en_HK
dc.identifier.eissn1878-3686-
dc.identifier.isiWOS:000253026200010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYang, ZF=14018809600en_HK
dc.identifier.scopusauthoridHo, DW=7402971906en_HK
dc.identifier.scopusauthoridNg, MN=23478329500en_HK
dc.identifier.scopusauthoridLau, CK=7401968442en_HK
dc.identifier.scopusauthoridYu, WC=37022285400en_HK
dc.identifier.scopusauthoridNgai, P=23477971900en_HK
dc.identifier.scopusauthoridChu, PWK=7402159518en_HK
dc.identifier.scopusauthoridLam, CT=7402989860en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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